EC Number   |
General Information |
Reference |
|---|
   3.4.21.109 | evolution |
matriptase shares high sequence similarity with matriptase-2, particularly in the catalytic domain which is about 45% identical |
731663 |
| 3.4.21.109 | evolution |
matriptase-2 belongs to the family of type II transmembrane serine proteases |
731386 |
| 3.4.21.109 | evolution |
matriptase-2 belongs to the family of type II transmembrane serine proteases, representing an emerging class of cell surface proteolytic enzymes. Matriptase-2 shares high sequence similarity with matriptase, particularly in the catalytic domain which is about 45% identical |
731663 |
| 3.4.21.109 | evolution |
the enzyme is a member of the TTSP family |
732419 |
| 3.4.21.109 | malfunction |
a mutation in matriptase is implicated in autosomal recessive ichtyosis withhypotrichosis a rare skin disease |
732309 |
| 3.4.21.109 | malfunction |
downregulation of the enzyme stabilizes fetuin-A in the unprocessed form |
731410 |
| 3.4.21.109 | malfunction |
expression of matriptase is frequently dysregulated in human cancers |
731477 |
| 3.4.21.109 | malfunction |
hepatocyte growth factor activator inhibitor-1 knockout mice with one or two wild-type matriptase alleles die in utero. Knockout mice on the matriptase hypomorphic mouse background complete embryonic development, are viable, healthy, and display normal long-term survival. Matriptase is identified as a critical inhibitory target for hepatocyte growth factor activator inhibitor-1 in keratinized squamous epithelium and a delicate balance between matriptase and hepatocyte growth factor activator inhibitor-1 maintains homeostasis of adult mammalian tissues |
707041 |
| 3.4.21.109 | malfunction |
lack of the putative endocytosis motif in the cytoplasmic domain largely abolishes the sensitivity of the enzyme to iron depletion |
732181 |
| 3.4.21.109 | malfunction |
mammary epithelial growth and morphogenesis in the presence of the latent form hepatocyte growth factor (pro-HGF) is blocked either by addition of SFTI1 an inhibitor of the Epi/MTP protease activity or by siRNA knockdown of the Epi/MTP expression |
709803 |
