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Literature summary for 3.4.21.109 extracted from
- Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality (2009), Am. J. Pathol., 174, 2015-2022.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skin | matriptase co-localizes with hepatocyte growth factor activator inhibitor-1 (HAI-1) in the epidermis | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matriptase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | hepatocyte growth factor activator inhibitor-1 knockout mice with one or two wild-type matriptase alleles die in utero. Knockout mice on the matriptase hypomorphic mouse background complete embryonic development, are viable, healthy, and display normal long-term survival. Matriptase is identified as a critical inhibitory target for hepatocyte growth factor activator inhibitor-1 in keratinized squamous epithelium and a delicate balance between matriptase and hepatocyte growth factor activator inhibitor-1 maintains homeostasis of adult mammalian tissues | Mus musculus |
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Release 2023.1 (January 2023)
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