EC Number   |
General Information |
Reference |
|---|
   3.4.14.5 | malfunction |
DPP-IV knockout mice have no major differences in the leukocytes populations in spleen, thymus and blood as compared to their wild type controls |
702894 |
| 3.4.14.5 | malfunction |
DPP4-deficient rats are resistant to developing diabetes, while susceptible to dyslipidaemia and reduction of glomerular filtration rate by streptozotocin |
704840 |
| 3.4.14.5 | physiological function |
Dipeptidyl peptidase IV expression level and activity is significantly increased by small activating RNA in JAR cells. Specific inhibitor diprotin A inhibits its activity at both basal and activated levels. Dipeptidyl peptidase IV does not regulate matrix metalloprotease MMP-9 expression but represses MMP-9 activity. The invading ability of JAR cells is reduced by by small activating RNA but increased by diprotin A |
731946 |
| 3.4.14.5 | physiological function |
dipeptidyl peptidase IV regulates T lymphocyte activation |
703264 |
| 3.4.14.5 | physiological function |
DPP IV contributes to virulence of streptococcal toxic shock syndrome-causing Streptococcus suis serotype 2 |
703337 |
| 3.4.14.5 | physiological function |
DPP-IV is released from muscle and induces an order-dependent increase in arteriolar diameter, with the largest change in the 6A arterioles. DPP-IV appears to act on neuropeptide Y to attenuate vasoconstriction |
755013 |
| 3.4.14.5 | physiological function |
DPP4 activation may be responsible for hyperglycaemia, lipid metabolism and preservation of renal function |
704840 |
| 3.4.14.5 | physiological function |
DPPIV overexpression may lead to the reduced tumorigenicity and restoration of sensitivity to paclitaxel in epithelial ovarian carcinoma cells in vitro and in vivo |
703039 |
| 3.4.14.5 | physiological function |
DPPIV plays a key role in the estradiol-regulated biofilm formation of Prevotella aurantiaca. Estradiol regulates the proliferation and biofilm formation, and these events significantly depend on DPPIV activity. Biofilm and DPPIV enzyme activity-related virulence of Prevotella aurantiaca may be inhibited, at least partly, by the disruption of quorum sensing signaling with C1-alkyl analogs of dihydroxy-2,3-pentaedione |
752462 |
| 3.4.14.5 | physiological function |
DPPIV promotes apoptosis in neuroblastoma cells through caspase activation and decreased Akt phosphorylation, and inhibits stromal-derived factor 1-mediated in vitro cell migration and angiogenic potential. DPPIV plays a potential role in inhibiting neuroblastoma growth and progression |
706014 |
