EC Number   |
General Information |
Reference |
|---|
   3.1.4.12 | evolution |
the enzyme belongs to the DNase I superfamily, which contains the exo-endo-phosphatase domain, the domain lacks only in isozyme Sph4, all isozymes lack the beta-hairpin loop, the organism encodes genes Sph1, Sph2, Sph3, Sph4 and SphH, structure comparisons, overview |
-, 730227 |
| 3.1.4.12 | evolution |
the enzyme from Streptomyces seems to be a typical bacterial SMase with a primary structure unusual for known bacterial SMases, primary structure comparisons and phylogenetic analysis |
-, 730073 |
| 3.1.4.12 | evolution |
the enzyme is a member of the metallophosphoesterase enzyme family |
730060 |
| 3.1.4.12 | malfunction |
acid SMase-deficient mice show reduced pulmonary ceramide levels and attenuated leukocyte influx into the alveolar space |
701641 |
| 3.1.4.12 | malfunction |
acid sphingomelin-specific drugs and multiple small interfering RNAs strongly inhibit the infection by ebolavirus and ebolavirus glycoprotein pseudotyped viruses but not by the pseudotypes bearing the glycoprotein of vesicular stomatitis virus, overview. ASMase siRNA-treated cells resist EBOV infection |
730294 |
| 3.1.4.12 | malfunction |
acid sphingomyelinase inhibition causes cellular sphingomyelin accumulation, which induces cancer cell death specifically in hypoxic tumor spheroids |
750265 |
| 3.1.4.12 | malfunction |
an inborn deficiency in aSMase activity leads to a lysosomal storage of sphingomyelin and a fatal pathology that has been designated as the type A and type B of Niemann-Pick-disease |
714689 |
| 3.1.4.12 | malfunction |
decreasing ceramide levels by inhibiting ceramide synthase or neutral sphingomyelinase 2 leads to translocation of membrane-bound aPKC to the cytosol, concurrent with its activation and the phosphorylation of its substrate Aurora kinase A. Ceramide depletion leads to translocation of aPKC from the primary cilium and the apicolateral cell membrane to the cytosol |
730356 |
| 3.1.4.12 | malfunction |
deficiency of the enzyme leads to lysosomal accumulation of sphingomyelin resulting in in Niemann-Pick types A and B diseases |
716445 |
| 3.1.4.12 | malfunction |
enzyme ablation reduces cell polarity |
750622 |
