EC Number   |
General Information |
Reference |
|---|
   2.7.7.6 | drug target |
sorangicin A inhibits the wild-type and mutant RNA polymerase through different mechanisms. It has a better pharmacokinetic profile than rifampicin, making it a suitable starting molecule to design drugs to be used for the treatment of tuberculosis patients with comorbidities who require multiple medications |
-, 762292 |
| 2.7.7.6 | drug target |
the template-DNA binding site is a target site for developing antibacterial agents |
762047 |
| 2.7.7.6 | evolution |
genotyping and phylogenetic analysis of gene rpoB encoding the beta subunit of the DNA-directed RNA polymerase of phytoplasmas from different plant origins, detailed overview |
-, 738427 |
| 2.7.7.6 | evolution |
human mitochondrial RNA polymerase is distantly related to the bacteriophage T7 class of single-subunit RNAPs with a probably similar mechanisms for nucleotide binding, substrate selection and catalysis/nucleotidyl transfer. The C-terminal domain contains the regions of highest similarity to the phage RNAPs. Early in the evolution of eukaryotes there has been a switch from a multi-subunit prokaryotic polymerase to a single-subunit, phage-derived polymerase, encoded in the nuclear genome and imported into the mitochondria, to serve as the transcriptase of the mitochondrial genome. The POLRMT CTD is characteristic of the Pol I family of nucleic acid polymerases, typically described as resembling the shape of a cupped right hand, containing the fingers, palm and thumb subdomains. The palm subdomain contains several key structural motifs that are highly conserved among the different classes of nucleic acid polymerases |
721721 |
| 2.7.7.6 | evolution |
Rpo41 utilizes a promoter recognition loop to bind and recognize its promoter, analogous to the use of the specificity loop by T7 RNAP for this purpose |
721721 |
| 2.7.7.6 | evolution |
the rpo genes that encode the enzyme subunits, rpoA, rpoB, rpoC1, and rpoC2, are relatively rapidly evolving sequences. Determination of the rate of the molecular evolution of rpo genes and to evaluation as phylogenetic markers on the example of the genus Lamium, Lamiaceae, represented by 66 specimens. Distribution of substitution rates across rpo genes as calculated in HyPhy using the GTR model of evolution, overview. The process of evolution of the RNA polymerase type I enzyme in genus Lamium is due not only to the genetic drift |
738415 |
| 2.7.7.6 | evolution |
YonO and related proteins present in various bacteria and bacteriophages have diverged from msRNAPs before the Last Universal Common Ancestor, and, thus, may resemble the single-subunit ancestor of all multi-subunit RNA polymerases |
761991 |
| 2.7.7.6 | malfunction |
at lower concentrations, pyrimidine nucleoside analogs have the potential to more easily inhibit mitochondrial transcription and mediate toxicity, given the ability to be readily phosphorylated and serve as efficient substrates for the enzyme |
721721 |
| 2.7.7.6 | malfunction |
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus |
705982 |
| 2.7.7.6 | malfunction |
mutant Sc Rpb2 R512C is slow in elongation |
721702 |
