EC Number |
General Information |
Reference |
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2.7.12.2 | evolution |
bos5 from Botrytis cinerea, a gene that encodes a mitogen-activated protein kinase kinase (MAPKK), is homologous to OS-5 of Neurospora crassa |
-, 740497 |
2.7.12.2 | evolution |
the enzyme is a member of the MAP kinase family |
740944 |
2.7.12.2 | evolution |
the protozoan pathogen, Trypanosoma brucei brucei, possesses many protein kinases which show high homology to the catalytic domains of mitogen activated protein kinases (MAPKs) and their upstream regulators. The close relationship of MKK and MKKK kinase domains combined with the phylogenetic distance between trypanosomatids and model organisms makes direct experimentation required to delineate functional attributes of the parasite kinases |
-, 740416 |
2.7.12.2 | malfunction |
an mkk3 mutant shows both a hypersensitive response in plant hormone gibberellin and a less sensitive response in red light signaling. Light-induced MAPK activation in wild-type seedlings and constitutive MAPK phosphorylation in dark-grown mkk3 mutant seedlings are found, respectively. The mkk3-1 mutant displays a gibberellic acid-hypersensitive phenotype in hypocotyl elongation, with an additiona long petiole phenotype |
741009 |
2.7.12.2 | malfunction |
bloodstream forms lacking MKK1 show decreased growth at 39°C as compared to the parental line, enzyme knockout phenotype, overview. The two mkk1 knockout clones are moderately more sensitive to temperature stress than the wild-type |
-, 740416 |
2.7.12.2 | malfunction |
D-domain mutant CAMKK7DELTAD is inactive toward MPK6 but the activity toward MPK3 is maintained, and the CAMKK7DELTAD mutant loses stomatal cluster-promoting activity |
741160 |
2.7.12.2 | malfunction |
enzyme knockout phenotype, overview |
-, 740416 |
2.7.12.2 | malfunction |
enzyme mutants show embryonic lethality. Mkk4 knockout embryonic stem cells exhibit diminished p-ATF2 and MEF2C expression, resulting in impaired MHC induction and defective cardiomyocyte differdifferentiation. Loss of MKK4 significantly blocks the induction of Mhca and Mhcb, but had no effect on expression of Mlc. Exogenous MKK4 expression partially restores the ability of Mkk4-/- embryonic stem cells to differentiate into cardiomyocytes. Mice lacking either MKK4 or MKK7 display an analogous embryonic lethal phenotype that may be attributed, at least in part, to insufficient JNK activation |
740701 |
2.7.12.2 | malfunction |
enzyme mutants show embryonic lethality. Mkk7 knockout embryonic stem cells show elevated phosphorylation of MKK4, p38, and ATF2, and increased MEF2C expression. The mutant cells show higher expression of MHC and MLC and enhanced formation of contractile cardiomyocytes. Mice lacking either MKK4 or MKK7 display an analogous embryonic lethal phenotype that may be attributed, at least in part, to insufficient JNK activation |
740701 |
2.7.12.2 | malfunction |
enzyme ZmMKK1 overexpression in Arabidopsis thaliana plants enhances the tolerance to salt and drought stresses, and the expression of ROS scavenging enzyme- and ABA-related genes, such as POD, CAT, RAB18 and RD29A under salt and drought conditions. ZmMKK1-overexpressing Arabidopsis plants show enhanced sensitivity to abscisic acid in seed germination, root length and stomata aperture |
740902 |