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Literature summary for 2.7.12.2 extracted from

  • Geng, P.; Ou, J.; Xie, G.; Li, J.; Zhao, X.; Xiang, L.; Liao, Y.; Wang, N.; Liang, H.
    Mitogen-activated protein kinase kinase 4 gene polymorphism and cancer risk (2015), Medicine (Baltimore), 94, e0938.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Cloned(Commentary)

Cloned (Comment) Organism
gene MKK4, maps to chromosome 17p11.2 and encodes a 399-amino acid protein in humans spans over 120 kb and consists of 11 exons, for identification of the genetic effects of the -1304T>G polymorphism on cancer risk, a meta-analysis composed of the publications evaluating the association between the -1304T>G polymorphism and risk of cancer is performed, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information association between -1304T>G (rs3826392) polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in a southern Chinese population Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P45985
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell
-
 Homo sapiens
-
cervical cancer cell
-
 Homo sapiens
-
colon cancer cell
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
esophageal cancer cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
nasopharyngeal carcinoma cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
JNKK1
-
 Homo sapiens
MAP2K4
-
 Homo sapiens
MEK4,
-
 Homo sapiens
mitogen-activated protein kinase kinase 4
-
 Homo sapiens
MKK4
-
 Homo sapiens
SEK1
-
 Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme is a member of the MAP kinase family Homo sapiens
malfunction MKK4 is highly mutated and has a pro-oncogenic role in cancers of pancreatic, breast, colon, prostate, skin, and laryngeal squamous cell. Strong association between -1304T>G (rs3826392) polymorphism in the promoter of MKK4 gene and a decreased risk of sporadic colorectal cancer in a southern Chinese population, overview Homo sapiens
metabolism MKK4 belongs to MAPK pathways known to have involvement in the regulation of apoptosis, inflammation, and tumorigenesis Homo sapiens
physiological function the enzyme plays a key role in multiple physiologic and pathophysiologic processes such as inflammation and tumor suppression Homo sapiens