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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19malfunction KIAA1199 protein silencing by siRNA results in a marked reduction in the phosphorylation of glycogen phosphorylase brain form, PYGB, by PHK 741081
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19malfunction PhKG1 knockdown reduces human umbilical vein endothelial cell tube formation and migration 728415
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19malfunction PhKG1a knockdown inhibits angiogenic intersegmental vessels formation 728415
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19malfunction phosphorylase kinase beta knockdown impairs proliferation of colorectal cancer in vitro and in vivo and induced cell cycle arrest 761576
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19metabolism proposed model of glycogen metabolism through the activation of PHK and PYG pathways in cancer cells with or without KIAA1199 overexpression, overview. PYG plays a central role in the mobilization of carbohydrate reserves in a wide variety of organs and tissues 741081
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19metabolism the enzyme phosphorylates and activates glycogen phosphorylase in the cascade activation of glycogenolysis 762341
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19metabolism the enzyme plays a key role in the cascade system for regulating glycogen metabolism 740638
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19physiological function glycogen phosphorylase kinase (PHK) is a serine/threonine-specific protein kinase that phosphorylates a serine residue in glycogen phosphorylase (PYG), triggering the activation of this latter enzyme that catalyzes the phosphorolytic cleavage of the alpha-1,4 glycosidic linkages of glycogen, releasing glucose-1-phosphate as the reaction product. The glycogen phosphorylase kinase beta-subunit (PHKB) interacts with the C-terminal region of KIAA1199 protein, that is associated with cancer cell migration or invasion and a poor prognosis and with non-syndromic hearing loss. KIAA1199 protein also interacts with glycogen phosphorylase brain form (PYGB) under serum-free conditions. The interaction promotes glycogen breakdown and cancer cell survival. KIAA1199 binding protein pull down assay, overview 741081
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19physiological function glycogen phosphorylase, EC 2.4.1.1, exists in two interconvertible forms, GPa (phosphorylated form, high activity) and GPb (nonphosphorylated form, low activity). Phosphorylase kinase catalyses the phosphorylation of GPb and plays a key role in the cascade system for regulating glycogen metabolism 740638
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.19physiological function phosphorylase kinase subunit G1 (PhKG1) is implicated in angiogenesis 728415
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