EC Number   |
General Information |
Reference |
|---|
    1.8.1.9 | drug target |
anti-cancer target. Selenocysteine is important for the biological functions of mammalian TrxR and distinguishes it from prokaryotic thioredoxin reductases. Therefore it is a promising drug target |
764704 |
| 1.8.1.9 | drug target |
drug-resistant Staphylococcus aureus, especially methicillin-resistant (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA), pose a great threat to human health globally. The Trx system in GSH-deficient pathogens is a viable antibacterial drug target |
-, 764835 |
| 1.8.1.9 | drug target |
ebselen as an inhibitor of thiol-dependent enzymes in pathogens |
764704 |
| 1.8.1.9 | evolution |
based on sequence analysis, YpdA belongs to the pyridine nucleotide-disulfide oxidoreductase family of proteins that use flavin adenine dinucleotide (FAD) to transport reducing equivalents from NAD(P)H to cysteine residues |
-, 765396 |
| 1.8.1.9 | malfunction |
ablation of cytosolic thioredoxin reductase (Txnrd1) or mitochondrial thioredoxin reductase (Txnrd2) yields embryonic lethal phenotypes |
696435 |
| 1.8.1.9 | malfunction |
cells deficient in isoformTR1 are particularly sensitive to diamide, while isoform TR3-knockdown cells are more sensitive to hydrogen peroxide |
711146 |
| 1.8.1.9 | malfunction |
combined deficiencies of three thioredoxin m isoforms and NADPH-dependent thioredoxin reductase C (NTRC) leads to a cumulative decrease in leaf pigmentation, tetrapyrrole biosynthesis intermediate contents, 5-aminolevulinic acid synthesis rate, and Mg-protoporphyrin IX methyltransferase activity |
765589 |
| 1.8.1.9 | malfunction |
in plants with altered content of the NADPH-dependent chloroplast thioredoxin system, the strict correlation between lumenal pH and non-photochemical quenching is partially lost |
765541 |
| 1.8.1.9 | malfunction |
in the absence of NTRC, imbalanced metabolic activities presumably modulate the chloroplast retrograde signals, leading to altered expression of nuclear genes and, ultimately, to the formation of the pleiotrophic phenotypes in ntrc mutant plants |
-, 713307 |
| 1.8.1.9 | malfunction |
inhibition of mitochondrial thioredoxin reductase leads to oxidation of downstream enzymes such as thioredoxin and peroxiredoxin |
712943 |
