EC Number |
General Information |
Reference |
---|
1.14.99.38 | malfunction |
decitabine-induced hypomethylation of the cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells |
746440 |
1.14.99.38 | malfunction |
loss of function of Ch25h leads to susceptibility to viral infections in vitro |
727611 |
1.14.99.38 | malfunction |
mice with a disruption in the cholesterol 25-hydroxylase gene regulate cholesterol metabolism normally. Ch25h-/- mice have higher levels of mRNAs coding for immunoglobulin A and immunoglobulin J. Disruption in the Cyp7b1 gene leads to significantly increased levels of 25-hydroxycholesterol in the circulation, and to significantly lower levels of IgA compared to wild-type mice |
727109 |
1.14.99.38 | malfunction |
patients with hereditary spastic paresis, a rare inherited disease with mutations in the CYP7B1 gene, have highly elevated levels of 25- and 27-hydroxycholesterol but normal levels of cholesterol and bile acids |
727109 |
1.14.99.38 | more |
25-hydroxycholesterol does not stimulate the sPLA2-IIA promoter in the mouse Schwann cell line MSC80 |
727109 |
1.14.99.38 | more |
Ch25h expression is controlled primarily by type I IFN signaling, type1 IFN-mediated Ch25h expression is IFNR-dependent, overview |
-, 715833 |
1.14.99.38 | more |
the high concentrations of vitamin D3 metabolites required for upregulation of the cholesterol 25-hydroxylase gene makes it unlikely that these metabolites are important regulators of cholesterol 25-hydroxylase in vivo |
727109 |
1.14.99.38 | physiological function |
adenovirus-mediated enzyme overexpression in mice improves glucose tolerance and insulin sensitivity and lowers the homeostatic model assessment for insulin resistance score |
745450 |
1.14.99.38 | physiological function |
cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication |
745479 |
1.14.99.38 | physiological function |
cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication |
745658 |