EC Number   |
General Information |
Reference |
|---|
    1.1.1.141 | malfunction |
MKN45 cells stably transfected with the 15-PGDH siRNA plasmid have a significantly increased proliferation rate. SGC7901 cells (disclosing a low expression level of 15-PGDH) stably transfected with the 15-PGDH cDNA have a significantly decreased growth rate. Increased expression of 15-PGDH suppresses clone formation of gastric cancer cells in plate and soft agar colony formation assays in vitro and suppressed tumor formation in athymic nude mice in vivo. Stable silencing of 15-PGDH in gastric cancer cells also enhances cell cycle entry in vitro |
724691 |
| 1.1.1.141 | malfunction |
overexpression of 15-PGDH inhibits HCC cell growth in vitro, whereas knockdown of 15-PGDH enhances tumor growth parameters |
726080 |
| 1.1.1.141 | metabolism |
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase protects against LPS/GalN-induced liver injury and the effect is mediated via 15-keto-PGE2, which activates PPAR-gamma in Kupffer cells and thus inhibits their ability to produce inflammatory cytokines |
763614 |
| 1.1.1.141 | metabolism |
the enzyme is a tumor suppressor in various malignancies including colon cancer. The product (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate (15-keto PGE2) stimulates the Nrf2-HO-1 axis through the generation of ROS in normal colon epithelial cells, which contributes to the potential role of this lipid mediator in preventing cancer development associated with oxidative stress and inflammatory tissue damage |
762674 |
| 1.1.1.141 | physiological function |
15-PGDH has a suppressive role and that its upregulation could partly reverse the malignant growth potential of gastric cancer cells both in vitro and in vivo |
724691 |
| 1.1.1.141 | physiological function |
15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21WAF1/Cip1 |
726080 |
| 1.1.1.141 | physiological function |
in a tumor xenograft model in severe combined immunodeficiency mice, inoculation of human HCC cells (Huh7) with overexpression of 15-PGDH leads to significant inhibition of tumor growth, whereas knockdown of 15-PGDH enhances tumor growth |
726080 |
| 1.1.1.141 | physiological function |
the enzyme inhibits cholangiocarcinoma cell proliferation and migration |
740709 |
| 1.1.1.141 | physiological function |
the enzyme regulates postnatal kidney development through interaction with cyclooxygenase 2 |
739837 |
