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Literature summary for 1.1.1.141 extracted from

  • Lu, D.; Han, C.; Wu, T.
    15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21(WAF1/Cip1.) (2013), Oncogene, 33, 1101-1112.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
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Homo sapiens
15-PGDH
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Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of 15-PGDH inhibits HCC cell growth in vitro, whereas knockdown of 15-PGDH enhances tumor growth parameters Homo sapiens
physiological function 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21WAF1/Cip1 Homo sapiens
physiological function in a tumor xenograft model in severe combined immunodeficiency mice, inoculation of human HCC cells (Huh7) with overexpression of 15-PGDH leads to significant inhibition of tumor growth, whereas knockdown of 15-PGDH enhances tumor growth Homo sapiens