Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Huh-7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
15-PGDH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of 15-PGDH inhibits HCC cell growth in vitro, whereas knockdown of 15-PGDH enhances tumor growth parameters | Homo sapiens |
physiological function | 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21WAF1/Cip1 | Homo sapiens |
physiological function | in a tumor xenograft model in severe combined immunodeficiency mice, inoculation of human HCC cells (Huh7) with overexpression of 15-PGDH leads to significant inhibition of tumor growth, whereas knockdown of 15-PGDH enhances tumor growth | Homo sapiens |