EC Number   |
Expression |
Reference |
|---|
    3.5.1.23 | down |
acid ceramidase expression in gingival cells is suppressed by stimulation with Porphyromonas gingivalis in vitro |
752674 |
| 3.5.1.23 | down |
acid ceramidase protein and mRNA are decreased during egg aging |
719536 |
| 3.5.1.23 | down |
gemcitabine downregulates the neutral ceramidase |
733408 |
| 3.5.1.23 | down |
significantly decreased ceramide levels are observed in human colon cancers, gliomas, ovarian cancers, thyroid and gastrointestinal cancers |
719536 |
| 3.5.1.23 | down |
the prominent antiestrogen tamoxifen is a pan-effective acid ceramidase inhibitor in the low micromolar range, as demonstrated in a wide spectrum of cancer cell types, prostate, pancreatic, colorectal, and breast. Tamoxifen does not impact cell viability or inhibit the enzyme activity in cell-free assays. Mechanism of action via increases in lysosomal membrane permeability, and time- and dose-dependent downregulation of acid ceramidase protein expression, overview. The downregulation can be blocked by a cathepsin B inhibitor |
733395 |
| 3.5.1.23 | up |
A-375 cells are induced by doxycycline to overexpress the enzyme |
753979 |
| 3.5.1.23 | up |
acid ceramidase is overexpressed in most prostate tumors |
719608 |
| 3.5.1.23 | up |
ACTH/cAMP signaling stimulates acid ceramidase ASAH1 transcription and activity |
720471 |
| 3.5.1.23 | up |
ACTH/cAMP signaling stimulates the enzyme transcription and activity |
720471 |
| 3.5.1.23 | up |
infection with the rice strip virus or treatment with insecticides significantly increase LsnCer mRNA expression and its enzymatic activity in Laodelphax striatellus, quantitative real time PCR enzyme expression analysis |
733976 |
