EC Number |
Expression |
Reference |
---|
3.4.24.B5 | down |
endothelin-1 (ET-1) downregulates matrix metalloproteinase 15 expression in human first trimester trophoblasts via endothelin receptor type B (ETRB). ET-1 downregulates MMP15 mRNA and protein levels. TNF-alpha enhances ET-1-mediated MMP15 downregulation in primary trophoblasts |
753776 |
3.4.24.B5 | down |
inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. Roscovitine treatment of follicles inhibits Pgr binding to the mmp15 promoter region |
753226 |
3.4.24.B5 | more |
after phosphorylation (by CDK9 and cyclin 1), Pgr becomes a functional transcription factor for mmp15 gene expression |
753226 |
3.4.24.B5 | up |
Mmp15 is an luteinizing hormone (LH)-inducible enzyme |
753226 |
3.4.24.B5 | up |
the enzyme is significantly up-regulated in placentas from severe early-onset preeclamptic pregnancies compared to gestationally matched preterm controls |
735055 |