EC Number   |
Expression |
Reference |
|---|
   3.4.21.73 | down |
downregulation of uPA and uPAR by early growth response 1, EGR1, forced expression of EGR1 decreases the expression of uPA and urokinase receptor uPAR proteins. uPA activity is decreased 0.49fold by EGR1 in Saos-2 cells |
718270 |
| 3.4.21.73 | down |
efficacy of grape seed extract in downregulating uPA expression and cell migration using highly metastatic androgen-independent PC-3 prostate cancer cells as a model. Grape seed extract inhibits DNA-binding activity of the transcription factor nuclear factor kappa B, which in turn decreases NFkB-dependent uPA transcription. Grape seed extract also inhibits NFkB-dependent urokinase plasminogen activator promoter activity |
717414 |
| 3.4.21.73 | down |
endogenous miR-193b expression inhibits uPA expression, anti-miR-193b increases uPA expression and increases cell invasion of breast cancer cells. During breast cancer cell metastasis, miR-193b expression is downregulated leading to increased uPA expression |
710163 |
| 3.4.21.73 | down |
in human endometrial cells, uPA and PAI-1 expression is regulated by steroid hormones such as estradiol, and progesterone. P4 suppresses uPA in epithelial cells and enhances inhibitor PAI-1 expression in both epithelial and stromal cells |
708237 |
| 3.4.21.73 | down |
inhibition of sphingosine kinase blocks basal expression of uPA and uPAR, as well as glioma cell invasion, however overexpression of sphingosine kinase does not augment sphingosine-1-phosphate receptor-mediated enhancement of uPA activity or invasion |
709905 |
| 3.4.21.73 | down |
inhibitors of p-ERK and p-p38 downregulate uPA in CFPAN-1 and PANC-1 cells, but these inhibitors affect uPAR considerably more than uPA |
708749 |
| 3.4.21.73 | down |
uPA and its endogenous inhibitor PAI-1 are downregulated by grape seed, Vitis ssp., proanthocyanidin extract, both at the RNA and protein levels, due to the extract's antioxidant activity |
710248 |
| 3.4.21.73 | up |
elevated levels of tissue inhibitor of metalloproteinases-1 , TIMP-1, render the liver more susceptible to metastasis by triggering urokinase plasminogen activator expression as well as hepatocyte growth factor signalling, thereby leading to the fatal scattered infiltration of metastasizing tumour cells throughout the parenchyma of the target organ |
717899 |
| 3.4.21.73 | up |
expression of uPA mRNA and enzyme production is increased by the addition of prostaglandin E2, PGE2, in cell lines of lung fibroblasts, although the cell surface uPA level is comparable to that of PGE2 untreated cells, overview |
710553 |
| 3.4.21.73 | up |
increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells. Reactive oxygen species, that occur in high rates in response to the freezing-thawing stimulus, actively participate in the induction of uPA expression in frozen-thawed and in vitro-cultured cells |
708237 |
