EC Number   |
Expression |
Reference |
|---|
   3.4.21.107 | down |
HtrA1 mRNA and protein levels are significantly decreased in endometrial cancer compared to normal tissues |
710167 |
| 3.4.21.107 | down |
HtrA3 expression is reduced or completely lost in over 50% of lung cancer cell lines and primary lung tumors from heavy smokers. An increased frequency of methylation within the first exon of HtrA3 corresponds to a loss of HtrA3 expression, particularly in tumors from smokers. 4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone results in HtrA3 downregulation with a corresponding increase in methylation. HtrA3 expression is reduced after 15 days of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone treatment (0.01 mM) |
717505 |
| 3.4.21.107 | up |
during acid stress, htrA is overexpressed in Streptococcus mutans strains K7 and UA159 |
713034 |
| 3.4.21.107 | up |
expression is significantly induced in parasite culture upon heat shock/oxidative stress |
731796 |
| 3.4.21.107 | up |
HTRA1 expression is increased in the pathogenesis of age-related macular degeneration |
713342 |
| 3.4.21.107 | up |
HTRA1 expression is upregulated in osteoarthritic joints, HTRA1 mRNA is increased by transforming growth factor-beta treatment (1 ng/ml for 24 h) in human primary chondrocytes |
712536 |
| 3.4.21.107 | up |
HtrA1 levels are highly elevated (about 7.8fold) in osteoarthritic cartilage |
712385 |
| 3.4.21.107 | up |
HTRA1 mRNA levels are 3fold higher in primary RPE cells homozygous for the HTRA1 promoter risk allele (rs11200638 -512 G>A), than in RPE cells with the wild type allele. This translates into a 2fold increase in HTRA1 secretion by RPE cells with the risk genotype |
712207 |
| 3.4.21.107 | up |
HTRA3 expression is initiated on day 12 after birth and upregulated during ovarian maturation with the highest levels found in the mature cycling ovary |
712615 |
| 3.4.21.107 | up |
in response to loss of anchorage, HtrA1 expression is upregulated in SKOV-3 cells, resulting in autocatalytic activation. Expression of HtrA1 is upregulated during anoikis |
711674 |
