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Literature summary for 3.4.21.107 extracted from

  • He, X.; Ota, T.; Liu, P.; Su, C.; Chien, J.; Shridhar, V.
    Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells (2010), Cancer Res., 70, 3109-3118.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial ovarian cancer cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-
TOV-21G cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in response to loss of anchorage, HtrA1 expression is upregulated in SKOV-3 cells, resulting in autocatalytic activation. Expression of HtrA1 is upregulated during anoikis up

General Information

General Information Comment Organism
malfunction stable knockdown of HtrA1 in SKOV-3 and TOV-21G cells results in resistance to anoikis due to enhanced activation of epidermal growth factor receptor/AKT pathway. Downregulation of HtrA1 significantly enhances the peritoneal dissemination of SKOV-3ip1 cells in nonobese diabetic/severe combined immunodeficient mice Homo sapiens
physiological function HtrA1 protease activity is required for inhibition of epidermal growth factor receptor signaling Homo sapiens