EC Number   |
Expression |
Reference |
|---|
   3.4.19.12 | down |
aberrant expression of UCHL1/PGP 9.5 in Schwann cells after nerve transection and even in fibroblasts after skin wounds |
710451 |
| 3.4.19.12 | down |
enzyme downregulation by RNAi in C33A cells. UCH L1 suppression inhibits cell proliferation and migration and induces G0/G1 arrest and apoptosis |
710371 |
| 3.4.19.12 | down |
germ cell apoptosis after testicular torsion treatment triggers downregulation of UCH-L1 in testis at both mRNA and protein levels |
695983 |
| 3.4.19.12 | down |
promoter hypermethylation represents a mechanism for the silencing of the UCHL1 gene expression in in renal carcinoma cells as a concept of an epigenetic control for the expression of UCHL1 during disease progression. Restoration of UCHL1 expression in renal carcinoma cells by treatment with DAC, overview |
709731 |
| 3.4.19.12 | down |
UCH-L1 expression is significantly decreased in middle cerebral artery occlusion, MCAO, rats |
709742 |
| 3.4.19.12 | down |
UCHL1 protein level is continuously declined during cell differentiation |
752667 |
| 3.4.19.12 | more |
ubiquitin C-terminal hydrolase UCH-L3 is upregulated in normal or non-metastatic prostate cancer cells and is downregulated in metastatic prostate cancer cell lines |
731261 |
| 3.4.19.12 | up |
2'-deoxy-5-azacytidine, DAC, induces UCHL1 expression in renal carcinoma cell lines linked to the demethylation degree of the UCHL1 promoter DNA. Restoration of UCHL1 expression in renal carcinoma cells by treatment with DAC, overview |
709731 |
| 3.4.19.12 | up |
camptothecin induces enzyme expression, also in RNAi silenced 293T and KR4 cells |
710371 |
| 3.4.19.12 | up |
expression of isoform UCHL1 is elevated in osteosarcoma |
731576 |
