EC Number   |
Expression |
Reference |
|---|
   3.3.2.6 | down |
knockdown of LTA4H inhibits anchorage-independent growth of HCT116 colon cancer cells |
707984 |
| 3.3.2.6 | up |
healthy smokers display elevated enzyme expression |
731112 |
| 3.3.2.6 | up |
human esophageal adenocarcinoma cell (EAC) and adjacent nontumor esophageal tissues reveal overexpression of LTA4H in EAC tissues compared to that in nontumor samples. LTA4H is overexpressed in several other human cancers, particularly lung adenocarcinoma, adenosquamous carcinoma, bronchioalveolar carcinoma, large cell carcinoma, thyroid adenocarcinoma, and gall bladder adenocarcinoma. Upregulation of LTA4H expression in primary effusion lymphoma, which is a rare HIV-associated non-Hodgkin B cell lymphoma |
752495 |
| 3.3.2.6 | up |
LTA4H is overexpressed in all rat esophageal adenocarcinoma (EAC) samples compared to that in the normal duodenal tissues in an esophagogastroduodenal anastomosis (EGDA) surgical model |
752495 |
| 3.3.2.6 | up |
LTA4H shows increased expression along with increased LTB4 in an azoxymethane-induced colorectal cancer (CRC) mouse model |
752495 |
| 3.3.2.6 | up |
significantly higher mRNA expression of the key enzymes 5-lipoxygenase, 5-LO activating protein, leukotriene A4 hydrolase, and prostaglandin E synthase 1 and their PGE receptors 2 and 3, occur in canine atopic dermatitis, a chronic inflammatory skin disease, overview |
708424 |
| 3.3.2.6 | up |
the enzyme expression is upregulated in keratinocytes by 2-chloroethyl ethyl sulfide via p38MAP kinase signaling pathway, inhibition of p38 MAP kinase suppresses CEES-induced expression of LTA4 hydrolase, overview |
710617 |
| 3.3.2.6 | up |
the enzyme is induced by HIV-1 infection, facilitating the protein transformation from the cytosol to the plasma membrane, which is linked to cathepsin B- and caspase 9, 3-dependent apoptosis, overview |
708048 |
