EC Number   |
Expression |
Reference |
|---|
   3.1.4.12 | down |
3-acetyl-11-keto-beta-boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells at high concentration 3-acetyl-11-keto-beta-boswellic acid decreases both the mass of acid SMase protein and the mRNA levels of acid SMase in the cells |
705457 |
| 3.1.4.12 | down |
acid SMase protein is decreased by 20% in both Hep-G2 and Caco-2 cells at 0.1 mM ezetimibe |
705473 |
| 3.1.4.12 | down |
acid SMase protein is decreased by 25% in the intestine and by 34% in the liver at 0.1 mM ezetimibe |
705473 |
| 3.1.4.12 | more |
ezetimibe up to 0.05 mM has no effects on acid phosphatase activity in both Hep-G2 and Caco-2 cells, no change of alkaline phosphatase activity is identified by ezetimibe |
705473 |
| 3.1.4.12 | up |
addition of tumor necrosis factor-alpha, interleukin-1beta, interferon-gamma, and lipopolysaccharide to C2C12 cells elicits significant increases in enzyme activity levels |
749539 |
| 3.1.4.12 | up |
all-trans-retinoic acid induces nSMase2 |
715614 |
| 3.1.4.12 | up |
ASM is NFAT2-inducible |
714052 |
| 3.1.4.12 | up |
electrophilic compounds such as diethyl malate, methyl mercury, and cigarette smoke extracts significantly enhanced the expression of acidic sphingomyelinase 6fold in bladder carcinoma ECV-304 cells |
729101 |
| 3.1.4.12 | up |
stimulation of bone marrow-derived mast cells with antigen results in about 2.5fold induction of enzyme activity |
729609 |
| 3.1.4.12 | up |
the enzyme expression increases in mother's milk gland during lactation |
729352 |
