EC Number   |
Posttranslational Modification |
Reference |
|---|
    4.2.1.3 | acetylation |
in vitro chemical acetylation with either acetic anhydride or acetyl-CoA results in increased aconitase activity that is reversed with SIRT3 treatment. Lysine residues K31, K138, K144, K401, K549, K689, K700, K701, and K723 represent the most responsive sites. A high fat diet (60% kcal from fat) also shows significantly increased mitochondrial aconitase activity without changes in protein level and produces increased aconitase acetylation at multiple sites |
747087 |
| 4.2.1.3 | more |
a postranslational activation-inactivation mechanism might be operating |
33814 |
| 4.2.1.3 | more |
identification of two mitochondrial forms of enzyme with N-formylkynurenine modifications |
681626 |
| 4.2.1.3 | phosphoprotein |
aconitase is phosphorylated on serine residues. Increase in extensor digitorum longus muscle enzyme activity upon repeated contraction is inhibited by cyclosporin A, an inhibitor of the protein phosphates calcineurin |
677458 |
| 4.2.1.3 | phosphoprotein |
mechanism controlling IRP1 activity at the level of its stability can be phosphorylation of Ser138, Ser138, Ser711, and flanking sequences are highly conserved |
696168 |
| 4.2.1.3 | phosphoprotein |
phosphorylation of mitochondrial aconitase by PKCbeta2 has regulatory function, overview |
697220 |
| 4.2.1.3 | phosphoprotein |
S711 is a phosphorylation site |
663958 |
| 4.2.1.3 | phosphoprotein |
S711 of IRP1 is phosphorylated by proteinkinase C in vitro and in vivo in human HEK cells. Aconitase activity of the S711 phosphomimetic mutants is preferentially inhibited in the citrate mode of aconitase function. The substitution of phosphomimetic amino acids for S711 fails to affect the RNA-binding affinity of IRP1 |
666706 |
| 4.2.1.3 | proteolytic modification |
the porcine heart enzyme is synthesized as a precursor containing a mitochondrial targeting sequence of 27 amino acid residues which is cleaved to yield a mature enzyme of 754 amino acids |
33813 |
| 4.2.1.3 | side-chain modification |
traces of carbohydrate of less than 1% |
33789 |
