EC Number   |
Application |
Reference |
|---|
    4.2.1.2 | analysis |
fumarate hydratase activity can be useful in the diagnosis of hereditary leiomyomatosis and renal cell cancer in cases with atypical presentation and undetectable fumarate hydratase mutations. Furthermore, fumarate hydratase activity testing is of value in laboratory investigations to elucidate the mechanism of hereditary leiomyomatosis and renal cell cancer |
681328 |
| 4.2.1.2 | industry |
use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast |
703151 |
| 4.2.1.2 | medicine |
elevation of total fumarase activity may attenuate the development of hypertension |
748868 |
| 4.2.1.2 | medicine |
fumarate hydratase activity can be useful in the diagnosis of hereditary leiomyomatosis and renal cell cancer in cases with atypical presentation and undetectable fumarate hydratase mutations. Furthermore, fumarate hydratase activity testing is of value in laboratory investigations to elucidate the mechanism of hereditary leiomyomatosis and renal cell cancer |
681328 |
| 4.2.1.2 | medicine |
fumarate immunohistochemistry may serve as a useful low-cost screening method to identify hereditary leiomyomatosis and renal cancer |
680092 |
| 4.2.1.2 | medicine |
metabolites of ibuprofen may play a role in its anti-cataract effect by protecting lenticular enzymes |
650370 |
| 4.2.1.2 | medicine |
the degradation of cell membranes in connection with necrosis leads to elevated fumarase activity in plasma and urine and hyperpolarized [1,4-13C2]malate production 24 h after reperfusion correlates with renal necrosis in a 40-min unilateral ischemic rat model. Fumarase activity screening on bio-fluids can detect injury severity. After verification of renal injury by bio-fluid analysis the precise injury location can be monitored by in vivo measurements of the fumarase activity non-invasively by hyperpolarized [1,4-13C]fumarate magnetic resonance imaging |
749342 |
| 4.2.1.2 | medicine |
whole-gene fumarate hydratase deletions are not a frequent cause of hereditary leiomyomatosis and renal cell cancer syndrome |
697077 |
| 4.2.1.2 | synthesis |
a pfl ldhA double mutant Escherichia coli strain NZN11 is used to produce succinic acid by overexpressing the Escherichia coli malic enzyme gene sfcA. This strain, however, produces a large amount of malic acid as well as succinic acid. The fumB gene encoding the anaerobic fumarase of Escherichia coli is co-amplified to solve the problem of malic acid accumulation, and subsequently improve the succinic acid production |
664402 |
| 4.2.1.2 | synthesis |
economic production of L-malate in an enzyme membrane reactor |
33774 |
