Literature summary for 4.2.1.2 extracted from

Shyadehi, A.Z.; Harding, J.J.
Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract (2002), Biochim. Biophys. Acta, 1587, 31-35.

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Application

Application	Comment	Organism
medicine	metabolites of ibuprofen may play a role in its anti-cataract effect by protecting lenticular enzymes	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
Cyanate	2 mM ibuprofen and its major metabolites protect by up to 26%. Ibuprofen and the metabolites do not bind to fumarase	Sus scrofa
D-fructose	2 mM ibuprofen and its major metabolites protect by up to 26%. Ibuprofen and the metabolites do not bind to fumarase	Sus scrofa
Prednisolone	2 mM ibuprofen and its major metabolites have no effect on prednisolone-induced inactivation	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Sus scrofa	-

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Release 2023.1 (January 2023)