EC Number   |
Application |
Reference |
|---|
   3.4.21.26 | drug development |
the discovery of enzyme inhibitors can revert memory loss caused by amnesic compounds in humans, developing a enzyme inhibitor from carbohydrate based materials |
683553 |
| 3.4.21.26 | drug development |
the enzyme is a pharmacological target for neurological diseases due to its high brain concentration and ability to cleave neuropeptides in vitro |
683344 |
| 3.4.21.26 | drug development |
the enzyme is a potential target for therapy of Chagas' disease |
683369 |
| 3.4.21.26 | food industry |
the enzyme can be used during mashing to produce gluten free beer |
-, 753447 |
| 3.4.21.26 | medicine |
coperfusion of enzyme into rat intestine with a highly digestive-resistant 33-mer peptide and partially proteolyzed gliadin. Enzyme supplementation helps in efficient processing of peptides resistant to proteolysis. Use of enzyme to treat patients with Celiac Sprue |
669992 |
| 3.4.21.26 | medicine |
enzyme at 20 mU/ml can partly degrade gliadin peptides in vitro and ex vivo and decreases the amount of intact peptides crosing the intestinal biopsy specimens of celiac disease patients but cannot prevent the intestinal passage of toxic or immunostimulatory metabolites. Enzyme concentrations of at least 500 mU/ml are required to achieve full detoxification |
668711 |
| 3.4.21.26 | medicine |
enzyme levels in postmortem brains of Alzheimers disease patients reveal significant increases in enzyme activity. Use of unsaturated fatty acids in preventing memory loss |
669025 |
| 3.4.21.26 | medicine |
inhibition of the enzyme may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases |
692518 |
| 3.4.21.26 | medicine |
involvement in pathogenesis of sleeping sickness suggested |
709834 |
| 3.4.21.26 | medicine |
positive effect of prolyl oligopeptidase inhibitors on learning and memory in animal models for amnesia, enzyme activity measurements in patient samples and (neuro)peptide degradation studies link the enzyme with neurodegenerative disorders |
694553 |
