EC Number   |
Application |
Reference |
|---|
    3.2.2.5 | analysis |
NADase fused to an amino-terminal fragment of anthrax toxin lethal factor is translocated across a synthetic lipid bilayer in vitro in the presence of anthrax toxin protective antigen in a pH-dependent manner. Exposure of human oropharyngeal keratinocytes to the fused NADase in the presence of protective antigen results in cytosolic delivery of NADase activity, inhibition of protein synthesis, and cell death |
751996 |
| 3.2.2.5 | analysis |
simple, fast and reliable fluorescence-based assay method to evaluate the NAD+ glycohydrolase activity of cell-permeable C3 proteins |
683850 |
| 3.2.2.5 | medicine |
CD157-deficient neutrophils from patients with paroxysmal nocturnal hemoglobinuria are characterized by a severely impaired diapedesis |
683287 |
| 3.2.2.5 | medicine |
CD38 rather than poly-ADP-ribose polymerase PARP-1, is an important source of ADP-ribose in mouse neutrophils and dendritic cells that use ADP-ribose as a secong messenger. ADP-ribose controls calcium influx and chemotaxis when cells are activated through chemokine receptors that rely on CD38 and cyclic ADP-ribose for activity |
683740 |
| 3.2.2.5 | medicine |
CovR and CovS two-component regulatory system regulates the Nga activity, which is considered important in the pathogenesis of STSS streptococcal toxic shock syndrome |
749603 |
| 3.2.2.5 | medicine |
treatment of lymphokine-activated killer cells with interleukin IL-8 results in internalization of CD38, which co-localizes with nonmuscle myosin heavy chain IIA and tyrosine kinase Lck. Blebbistatin blocks the internalization |
683667 |
| 3.2.2.5 | medicine |
tumor necrosis factor alpha upregulates CD38. Induced CD38 expression enhances inflammatory gene expression by decreasing ERK1/2 phosphorylation and increasing NF kappaB activation. It negatively affects the expression of osteoclast markers. CD38 may reduce osteoclastogenesis and increase inflammatory gene induction by decreasing cellular histone deacetylase activity |
683052 |
| 3.2.2.5 | medicine |
vaccination with CagL has protective efficacy in mice |
-, 749743 |
