EC Number   |
Application |
Reference |
|---|
    3.1.1.23 | diagnostics |
enzyme MGLL in tumor-associated macrophages predicts the survival of colorectal cancer patients |
751669 |
| 3.1.1.23 | drug development |
Differences in the binding pocket of mtbMGL compared to human MGL open the possibility for specific inhibition of MGL from the pathogen Mycobacterium tuberculosis and use in the human pathogen treatment |
-, 752247 |
| 3.1.1.23 | drug development |
potent MGL inhibitors with selectivity over FAAH may be realized by exploiting structural difference as well as the binding sub-pocket, increased volume around the catalytic site, and potential hydrogen-bonding opportunities |
709281 |
| 3.1.1.23 | drug development |
selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain. (2S,9Z)-octadec-9-ene-1,2-diamine is a selective inhibitor of MGL activity with in vivo analgesic and anti-inflammatory properties |
707661 |
| 3.1.1.23 | drug development |
structure of MAGL paves the way for future medicinal chemistry works aimed at the design of new drugs exploiting 2-arachidonoylglycerol transmission. MAGL is a hot therapeutic target, because the design of selective and potent inhibitors can provide unique tools to interfere with 2-arachidonoylglycerol degradation and to finely modulate the endocannabinoid signal |
708116 |
| 3.1.1.23 | drug development |
the enzyme is a target for design of potent and selective inhibitors |
679213 |
| 3.1.1.23 | medicine |
enzyme MAGL represents a potential target to treat diverse pathological conditions, including cancer |
751902 |
| 3.1.1.23 | medicine |
expression of macrophage MGLL is decreased in cancer tissues and positively correlated with the survival of cancer patients. Monoacylglycerol lipase is a switch for CB2/TLR4-dependent macrophage activation and a potential target for cancer therapy. Modulation of MGLL-CB2 axis in macrophages might be a promising strategy for cancer treatment |
751669 |
| 3.1.1.23 | medicine |
MGL represents a target for the treatment of inflammatory pain |
714640 |
| 3.1.1.23 | pharmacology |
the enzyme is a therapeutic target |
679213 |
