EC Number   |
Natural Substrates |
|---|
   3.4.24.B9 | amyloid precursor protein + H2O |
enzyme shows alpha-secretase activity, the alpha-secretase might be composed of several ADAM enzymes in a complexe |
| 3.4.24.B9 | heparin-binding EGF-like growth factor + H2O |
cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding |
| 3.4.24.B9 | more |
interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme |
| 3.4.24.B9 | more |
regulation of metalloprotease desintegrins via a cysteine-switch mechanism |
| 3.4.24.B9 | more |
the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+ |
| 3.4.24.B9 | more |
enzyme can cleave and release epidermal growth factor and FGFR2iiib from cells |
| 3.4.24.B9 | more |
enzyme is a polyvalent ligand, through its disintegrin domain, for multiple renal integrins of the beta1 class |
| 3.4.24.B9 | more |
potential ADAM-9 sheddase substrates include growth factors and cytokines, which have been linked to atherosclerosis |
| 3.4.24.B9 | pro-heparin-binding EGF-like growth factor + H2O |
cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding |
| 3.4.24.B9 | proteins + H2O |
- |
