EC Number   |
Activating Compound |
Reference |
|---|
   3.1.4.12 | 1-alpha,25-dihydroxyvitamin D3 |
- |
135175 |
| 3.1.4.12 | 1-oleoyl-rac-glycerol |
approx. 20% stimulation at 0.4-0.8 mM, inhibition above |
653103 |
| 3.1.4.12 | 1-stearoyl-rac-glycerol |
approx. 10% stimulation at 0.8 mM, inhibition above |
653103 |
| 3.1.4.12 | 2-mercaptoethanol |
- |
135188 |
| 3.1.4.12 | 2-mercaptoethanol |
activates in vivo by severalfold |
729171 |
| 3.1.4.12 | Activator proteins |
from human spleen, two forms of |
135151, 135152 |
| 3.1.4.12 | albumin |
20% activation of enzyme A and B |
135169 |
| 3.1.4.12 | anionic phospholipids |
APLs, the enzymatic activity of nSMase2 is dependent on anionic phospholipids, structural requirements for APL-selective binding of nSMase2, overview. nSMase2 interacts specifically and directly with several APLs, including phosphatidylserine and phosphatidic acid. Identification of two discrete APL binding domains in the N terminus of nSMase2, the nSMase2 N-terminal domain is essential for nSMase interaction with APLs |
715616 |
| 3.1.4.12 | arachidonic acid |
- |
135183 |
| 3.1.4.12 | arachidonic acid |
approx. 20% stimulation at 0.4-0.8 mM, inhibition above |
653103 |
