1.14.18.9Gene ontology ID
GO:0000254
Definition
Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O
Comment
Note that zymosterol is cholesta-8,24-dien-3-ol.
Synonyms
1. 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
2. 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)
3. 4-methylsterol oxidase activity
4. methylsterol hydroxylase activity
5. methylsterol monooxygenase activity
References
1. EC 1.14.18.92. PMID 98118803. MetaCyc 1.14.13.72-RXN4. Reactome: R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol"
5. Reactome: R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol"
6. RHEA: 55220
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