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Gene ontology
Version 2014-12-22
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Details for cyclin-dependent protein serine/threonine kinase activity
2.7.11.22
Gene ontology ID
GO:0004693
Definition
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)
Synonyms
1. ATP:cyclin phosphotransferase activity
2. cdc2 kinase activity
3. CDK
4. CDK activity
5. CDK, catalytic subunit activity
6. cdk-activating kinase activity
7. Cdk-activating protein kinase activity
8. cyclin D-cdk6 kinase activity
9. cyclin D-dependent kinase activity
10. cyclin E kinase activity
11. cyclin-A associated kinase activity
12. cyclin-dependent kinase 6 activity
13. cyclin-dependent kinase activity
14. cyclin-dependent kinase-2 activity
15. cyclin-dependent kinase-4 activity
16. cyclin-dependent protein kinase activity
17. cyclin-dependent protein kinase, intrinsic catalyst activity
18. D-type cyclin kinase activity
19. neuronal cdc2-like kinase activity
References
1. GOC: pr
2. GOC: rn
3. PMID 7877684
4. PMID 9841670
5. EC 2.7.11.22
6. MetaCyc 2.7.11.22-RXN
7. Reactome: R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex"
8. Reactome: R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex"
9. Reactome: R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
10. Reactome: R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2"
11. Reactome: R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2"
12. Reactome: R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
13. Reactome: R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75"
14. Reactome: R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21"
15. Reactome: R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21"
16. Reactome: R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2"
17. Reactome: R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)"
18. Reactome: R-HSA-188390 "Cyclin E:Cdk2-mediated phosphorylation of Rb"
19. Reactome: R-HSA-1912391 "NICD1 is phosphorylated by CDK8"
20. Reactome: R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB"
21. Reactome: R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants"
22. Reactome: R-HSA-2245218 "CDK1 phosphorylates PHF8"
23. Reactome: R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3"
24. Reactome: R-HSA-2430533 "CDK1 phosphorylates MASTL"
25. Reactome: R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres"
26. Reactome: R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms"
27. Reactome: R-HSA-2514854 "CDK1 phosphorylates condensin I"
28. Reactome: R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9"
29. Reactome: R-HSA-2990882 "CDK1 phosphorylates NUP98"
30. Reactome: R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2"
31. Reactome: R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1"
32. Reactome: R-HSA-4086410 "CDK1 phosphorylates BORA"
33. Reactome: R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1"
34. Reactome: R-HSA-5195402 "CDK1 phosphorylates LPIN"
35. Reactome: R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments"
36. Reactome: R-HSA-5692755 "CDK1 phosphorylates MAPK6"
37. Reactome: R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218"
38. Reactome: R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes"
39. Reactome: R-HSA-6805109 "CDK2 phosphorylates TP53"
40. Reactome: R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2"
41. Reactome: R-HSA-69005 "Cdc6 protein is phosphorylated by CDK"
42. Reactome: R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes"
43. Reactome: R-HSA-69754 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes"
44. Reactome: R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes"
45. Reactome: R-HSA-9008412 "CDK4 phosphorylates RUNX2"
46. Reactome: R-HSA-9009282 "CDK1 phosphorylates RUNX2"
Legend
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Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
regulation of cellular process is a
regulation of cell cycle is a
cyclin-dependent protein kinase activity part of
cyclin-dependent protein serine/threonine kinase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
positive regulation of biological process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
regulation of carbon utilization is a
regulation of cellular process is a
cell redox homeostasis is a
modulation by symbiont of host cellular process is a
regulation of actin filament-based process is a
regulation of binding of sperm to zona pellucida is a
regulation of cartilage condensation is a
regulation of cell activation is a
regulation of cell adhesion molecule production is a
regulation of cell aging is a
regulation of cell communication is a
regulation of cell cycle is a
cyclin-dependent protein kinase activity part of
cyclin-dependent protein serine/threonine kinase activity is a
regulation of cyclin-dependent protein kinase activity
regulation of cell cycle process is a
regulation of meiotic cell cycle is a
regulation of mitotic cell cycle is a
regulation of cell death is a
regulation of cell differentiation is a
regulation of cell division is a
regulation of cell killing is a
regulation of cell population proliferation is a
regulation of cell wall organization or biogenesis is a
regulation of cellular component biogenesis is a
regulation of cellular component movement is a
regulation of cellular component organization is a
regulation of cellular localization is a
regulation of cellular metabolic process is a
regulation of cellular pH reduction is a
regulation of cellular response to alcohol is a
regulation of cellular response to alkaline pH is a
regulation of cellular response to drug is a
regulation of cellular response to gamma radiation is a
regulation of cellular response to growth factor stimulus is a
regulation of cellular response to insulin stimulus is a
regulation of cellular response to macrophage colony-stimulating factor stimulus is a
regulation of cellular response to manganese ion is a
regulation of cellular response to oxidopamine is a
regulation of cellular response to stress is a
regulation of cellular response to testosterone stimulus is a
regulation of cellular response to thapsigargin is a
regulation of cellular response to tunicamycin is a
regulation of cellular response to very-low-density lipoprotein particle stimulus is a
regulation of cellular response to X-ray is a
regulation of chromosome segregation is a
regulation of conjugation is a
regulation of cytolysis is a
regulation of establishment or maintenance of cell polarity is a
regulation of horizontal cell localization is a
regulation of membrane depolarization is a
regulation of microtubule-based process is a
regulation of myelination is a
regulation of peroxidase activity is a
regulation of phenotypic switching is a
regulation of protein folding is a
regulation of response to cell cycle checkpoint signaling is a
regulation of secretion by cell is a
regulation of single-species biofilm formation is a
regulation of stomatal movement is a
regulation of transmembrane transport is a
regulation of transposition is a
regulation of vacuolar transport is a
regulation of vesicle-mediated transport is a
signal transduction is a
regulation of circadian rhythm is a
regulation of developmental pigmentation is a
regulation of developmental process is a
regulation of estrogen receptor binding is a
regulation of growth is a
regulation of guanyl-nucleotide exchange factor activity is a
regulation of hemostasis is a
regulation of immune system process is a
regulation of interspecies interactions between organisms is a
regulation of localization is a
regulation of locomotion is a
regulation of membrane hyperpolarization is a
regulation of metabolic process is a
regulation of multi-organism process is a
regulation of multicellular organismal process is a
regulation of nitrogen utilization is a
regulation of phosphorus utilization is a
regulation of plasma lipoprotein particle levels is a
regulation of reproductive process is a
regulation of response to stimulus is a
regulation of signaling is a
regulation of sulfur utilization is a
regulation of biological quality is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a