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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for chemical synaptic transmission
Gene ontology ID
GO:0007268
Definition
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse
Synonyms
1. neurotransmission
2. signal transmission across a synapse
3. synaptic transmission
References
1. GOC: jl
2. MeSH: D009435
3. Wikipedia: Neurotransmission
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
positive regulation of biological process is a
positive regulation of metabolic process is a
positive regulation of macromolecule metabolic process is a
positive regulation of gene expression is a
positive regulation of cytokine production is a
cytoplasmic pattern recognition receptor signaling pathway in response to virus is a
cellular process is a
cell communication is a
cell-cell signaling is a
synaptic signaling is a
trans-synaptic signaling is a
anterograde trans-synaptic signaling is a
chemical synaptic transmission is a
transmembrane transport is a
ion transmembrane transport is a
anion transmembrane transport is a
anion transmembrane transporter activity part of
organic anion transmembrane transporter activity is a
carboxylic acid transmembrane transporter activity is a
dicarboxylic acid transmembrane transporter activity is a
cellular_component is a
cellular anatomical entity is a
cell periphery is a651 BRENDA localization in branch, click for list of all
external encapsulating structure part of25 BRENDA localization in branch, click for list of all
cell wall is a23 BRENDA localization in branch, click for list of all
plant-type cell wall is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
positive regulation of biological process is a
positive regulation by symbiont of entry into host is a
positive regulation of action potential is a
positive regulation of asexual reproduction is a
positive regulation of biomineralization is a
positive regulation of cellular process is a
positive regulation of circadian rhythm is a
positive regulation of developmental pigmentation is a
positive regulation of developmental process is a
positive regulation of DNA-binding transcription factor activity is a
positive regulation of dosage compensation by inactivation of X chromosome is a
positive regulation of establishment of protein localization is a
positive regulation of establishment of RNA localization to telomere is a
positive regulation of growth is a
positive regulation of guanyl-nucleotide exchange factor activity is a
positive regulation of hemostasis is a
positive regulation of immune system process is a
positive regulation of lipid localization is a
positive regulation of locomotion is a
positive regulation of membrane depolarization is a
positive regulation of membrane hyperpolarization is a
positive regulation of metabolic process is a
positive regulation of alpha-(1->3)-fucosyltransferase activity is a
positive regulation of anthocyanin metabolic process is a
positive regulation of ATP metabolic process is a
positive regulation of biosynthetic process is a
positive regulation of carbohydrate metabolic process is a
positive regulation of catabolic process is a
positive regulation of cold-induced thermogenesis is a
positive regulation of collagen metabolic process is a
positive regulation of hormone metabolic process is a
positive regulation of lipid metabolic process is a
positive regulation of macromolecule metabolic process is a
positive regulation of gene expression is a
positive regulation of cytokine production is a
cytoplasmic pattern recognition receptor signaling pathway in response to virus is a
MDA-5 signaling pathway is a
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
RIG-I signaling pathway is a
positive regulation by virus of host cytokine production is a
positive regulation of chemokine production is a
positive regulation of connective tissue growth factor production is a
positive regulation of cytokine production involved in inflammatory response is a
positive regulation of fibroblast growth factor production is a
positive regulation of granulocyte macrophage colony-stimulating factor production is a
positive regulation of hepatocyte growth factor production is a
positive regulation of interferon-gamma production is a
positive regulation of interleukin-1 production is a
positive regulation of interleukin-10 production is a
positive regulation of interleukin-11 production is a
positive regulation of interleukin-12 production is a
positive regulation of interleukin-13 production is a
positive regulation of interleukin-14 production is a
positive regulation of interleukin-15 production is a
positive regulation of interleukin-16 production is a
positive regulation of interleukin-17 production is a
positive regulation of interleukin-18 production is a
positive regulation of interleukin-19 production is a
positive regulation of interleukin-2 production is a
positive regulation of interleukin-20 production is a
positive regulation of interleukin-21 production is a
positive regulation of interleukin-22 production is a
positive regulation of interleukin-23 production is a
positive regulation of interleukin-24 production is a
positive regulation of interleukin-25 production is a
positive regulation of interleukin-26 production is a
positive regulation of interleukin-27 production is a
positive regulation of interleukin-3 production is a
positive regulation of interleukin-32 biosynthetic process is a
positive regulation of interleukin-33 production is a
positive regulation of interleukin-34 production is a
positive regulation of interleukin-35 production is a
positive regulation of interleukin-4 production is a
positive regulation of interleukin-5 production is a
positive regulation of interleukin-6 production is a
positive regulation of interleukin-7 production is a
positive regulation of interleukin-8 production is a
positive regulation of interleukin-9 production is a
positive regulation of macrophage colony-stimulating factor production is a
positive regulation of platelet-derived growth factor production is a
positive regulation of transforming growth factor beta production is a
positive regulation of tumor necrosis factor superfamily cytokine production is a
positive regulation of type I interferon production is a
positive regulation of type III interferon production is a
positive regulation of vascular endothelial growth factor production is a
positive regulation of gene expression, epigenetic is a
positive regulation of histone gene expression is a
positive regulation of protein maturation is a
positive regulation of rhodopsin gene expression is a
positive regulation of protein metabolic process is a
positive regulation of NAD metabolic process is a
positive regulation of nitrogen compound metabolic process is a
positive regulation of olefin metabolic process is a
positive regulation of oxidoreductase activity is a
positive regulation of respiratory burst is a
positive regulation of small molecule metabolic process is a
positive regulation of mRNA alternative polyadenylation is a
positive regulation of multi-organism process is a
positive regulation of multicellular organismal process is a
positive regulation of nitrogen utilization is a
positive regulation of phosphorus utilization is a
positive regulation of posttranscriptional gene silencing is a
positive regulation of protein localization to cell-cell junction is a
positive regulation of protein localization to synapse is a
positive regulation of reproductive process is a
positive regulation of response to stimulus is a
positive regulation of short-term synaptic potentiation is a
positive regulation of signaling is a
positive regulation of sulfur utilization is a
positive regulation of telomerase RNA localization to Cajal body is a
positive regulation of transport is a
positive regulation of viral process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
regulation of carbon utilization is a
regulation of cellular process is a
regulation of circadian rhythm is a
regulation of developmental pigmentation is a
regulation of developmental process is a
regulation of estrogen receptor binding is a
regulation of growth is a
regulation of guanyl-nucleotide exchange factor activity is a
regulation of hemostasis is a
regulation of immune system process is a
regulation of interspecies interactions between organisms is a
regulation of localization is a
regulation of locomotion is a
regulation of membrane hyperpolarization is a
regulation of metabolic process is a
regulation of multi-organism process is a
regulation of multicellular organismal process is a
regulation of nitrogen utilization is a
regulation of phosphorus utilization is a
regulation of plasma lipoprotein particle levels is a
regulation of reproductive process is a
regulation of response to stimulus is a
regulation of signaling is a
regulation of sulfur utilization is a
regulation of biological quality is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
actin filament-based process is a
cell activation is a
cell adhesion molecule production is a
cell aggregation is a
cell communication is a
axon target recognition is a
cell communication by chemical coupling is a
cell communication by electrical coupling is a
cell-cell signaling is a
autocrine signaling is a
c-di-GMP signaling is a
cell-cell signaling by wnt is a
cell-cell signaling involved in amphid sensory organ development is a
cell-cell signaling involved in cell fate commitment is a
cell-cell signaling involved in kidney development is a
cell-cell signaling involved in lung development is a
cell-cell signaling involved in mammary gland development is a
cell-cell signaling involved in placenta development is a
cell-cell signaling via exosome is a
determination of muscle attachment site is a
ectoderm and mesoderm interaction is a
endocrine signaling is a
endodermal-mesodermal cell signaling is a
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification is a
epithelial-mesenchymal cell signaling is a
glial cell-neuron signaling is a
mesenchymal-epithelial cell signaling is a
mesodermal-endodermal cell signaling is a
neuron-glial cell signaling is a
paracrine signaling is a
polyphosphate-mediated signaling is a
quorum sensing is a
signal release part of
stromal-epithelial cell signaling involved in prostate gland development is a
synaptic signaling is a
synaptic signaling by nitric oxide is a
synaptic signaling via neuropeptide is a
trans-synaptic signaling is a
anterograde trans-synaptic signaling is a
anterograde trans-synaptic signaling by trans-synaptic protein complex is a
chemical synaptic transmission is a
neuromuscular synaptic transmission is a
neuron-neuron synaptic transmission is a
presynaptic process involved in chemical synaptic transmission part of
synaptic transmission, cholinergic is a
synaptic transmission, dopaminergic is a
synaptic transmission, GABAergic is a
synaptic transmission, glutamatergic is a
synaptic transmission, glycinergic is a
synaptic transmission, noradrenergic is a
synaptic transmission, serotonergic is a
retrograde trans-synaptic signaling is a
trans-synaptic signaling by BDNF is a
trans-synaptic signaling by lipid is a
trans-synaptic signaling by soluble gas is a
trans-synaptic signaling by trans-synaptic complex is a
visceral mesoderm-endoderm interaction involved in midgut development is a
cellular response to extracellular stimulus is a
extracellular matrix-cell signaling is a
motogenic signaling initiating cell movement in cerebral cortex is a
motogenic signaling involved in interneuron migration from the subpallium to the cortex is a
motogenic signaling involved in postnatal olfactory bulb interneuron migration is a
pollen-pistil interaction is a
sex determination, somatic-gonadal interaction is a
cell cycle is a
cell death is a
cell division is a
cell growth is a
cell killing is a
cell population proliferation is a
cell recognition is a
cell wall organization or biogenesis is a
cell-cell fusion is a
cellular component organization or biogenesis is a
cellular detoxification is a
cellular developmental process is a
cellular localization is a
cellular metabolic process is a
cellular pigmentation is a
cellular process involved in reproduction in multicellular organism is a
cellular response to stimulus is a
chromosome segregation is a
cytolysis is a
DNA clamp unloading is a
ensheathment of neurons is a
establishment or maintenance of cell polarity is a
establishment or maintenance of cell type involved in phenotypic switching is a
export from cell is a
intercellular transport is a
intermediate filament-based process is a
light absorption is a
localization of cell is a
membrane docking is a
microtubule organizing center localization is a
microtubule-based process is a
movement of cell or subcellular component is a
multi-organism cellular process is a
phenotypic switching is a
plasmid maintenance is a
process utilizing autophagic mechanism is a
protein folding is a
protein unfolding is a
RNA folding is a
signaling receptor ligand precursor processing is a
stomatal movement is a
syncytium formation is a
transmembrane transport is a
(+)-abscisic acid D-glucopyranosyl ester transmembrane transport is a
autoinducer AI-2 transmembrane transport is a
azole transmembrane transport is a
carbohydrate transmembrane transport is a
drug transmembrane transport is a
export across cell outer membrane is a
import across plasma membrane is a
ion transmembrane transport is a
anion transmembrane transport is a
3'-phospho-5'-adenylyl sulfate transmembrane transport is a
5'-adenylyl sulfate transmembrane transport is a
acetyl-CoA transmembrane transport is a
anion transmembrane transporter activity part of
arsenate ion transmembrane transporter activity is a
cyanate transmembrane transporter activity is a
inorganic anion transmembrane transporter activity is a
organic anion transmembrane transporter activity is a
acetyl-CoA transmembrane transporter activity is a
ADP transmembrane transporter activity is a
alkanesulfonate transmembrane transporter activity is a
AMP transmembrane transporter activity is a
ATP transmembrane transporter activity is a
ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity is a
ATPase-coupled fatty-acyl-CoA transmembrane transporter activity is a
ATPase-coupled glycerol-2-phosphate transmembrane transporter activity is a
bicarbonate transmembrane transporter activity is a
carboxylic acid transmembrane transporter activity is a
achromobactin transmembrane transporter activity is a
amino acid transmembrane transporter activity is a
ATPase-coupled carboxylic acid transmembrane transporter activity is a
dicarboxylic acid transmembrane transporter activity is a
5-formyltetrahydrofolate transmembrane transporter activity is a
alpha-ketoglutarate transmembrane transporter activity is a
bilirubin transmembrane transporter activity is a
C4-dicarboxylate transmembrane transporter activity is a
folic acid transmembrane transporter activity is a
isopropylmalate transmembrane transporter activity is a
malonate(1-) transmembrane transporter activity is a
methotrexate transmembrane transporter activity is a
oxalate transmembrane transporter activity is a
secondary active p-aminobenzoyl-glutamate transmembrane transporter activity is a
sodium:dicarboxylate symporter activity is a
gibberellin transmembrane transporter activity is a
glucuronoside transmembrane transporter activity is a
icosanoid transmembrane transporter activity is a
monocarboxylic acid transmembrane transporter activity is a
sialic acid transmembrane transporter activity is a
tricarboxylic acid transmembrane transporter activity is a
CMP-N-acetylneuraminate transmembrane transporter activity is a
coenzyme A transmembrane transporter activity is a
cyclic-GMP-AMP transmembrane transporter activity is a
dehydroascorbic acid transmembrane transporter activity is a
enterobactin transmembrane transporter activity is a
FAD transmembrane transporter activity is a
FMN transmembrane transporter activity is a
fosmidomycin transmembrane transporter activity is a
glucosinolate:proton symporter activity is a
glutathione transmembrane transporter activity is a
glycerol-3-phosphate transmembrane transporter activity is a
glycerophosphodiester transmembrane transporter activity is a
GTP:GDP antiporter activity is a
lysophospholipid:sodium symporter activity is a
pyridoxal phosphate transmembrane transporter activity is a
riboflavin transmembrane transporter activity is a
sodium-dependent organic anion transmembrane transporter activity is a
sodium-independent organic anion transmembrane transporter activity is a
UDP-glucose transmembrane transporter activity is a
UDP-N-acetylglucosamine transmembrane transporter activity is a
UDP-xylose transmembrane transporter activity is a
urate transmembrane transporter activity is a
potassium ion antiporter activity is a
salt transmembrane transporter activity is a
selenite:proton symporter activity is a
solute:anion antiporter activity is a
arsenate ion transmembrane transport is a
carboxylic acid transmembrane transport is a
CMP-N-acetylneuraminate transmembrane transport is a
coenzyme A transmembrane transport is a
FAD transmembrane transport is a
glutathione transmembrane transport is a
glycerol-2-phosphate transmembrane transport is a
glycerol-3-phosphate transmembrane transport is a
glycerophosphodiester transmembrane transport is a
inorganic anion transmembrane transport is a
mitochondrial ADP transmembrane transport is a
plasma membrane selenite transport is a
triose phosphate transmembrane transport is a
UDP-galactose transmembrane transport is a
UDP-glucose transmembrane transport is a
UDP-N-acetylgalactosamine transmembrane transport is a
UDP-N-acetylglucosamine transmembrane transport is a
UDP-xylose transmembrane transport is a
cation transmembrane transport is a
establishment or maintenance of transmembrane electrochemical gradient is a
inorganic ion transmembrane transport is a
ion transmembrane transporter activity part of
mobile ion carrier activity part of
mitochondrial transmembrane transport is a
nucleoside transmembrane transport is a
nucleotide transmembrane transport is a
nucleotide-sugar transmembrane transport is a
oligopeptide transmembrane transport is a
organic acid transmembrane transport is a
organomercurial transport is a
phytochelatin transmembrane transport is a
polyamine transmembrane transport is a
protein transmembrane transport is a
purine-containing compound transmembrane transport is a
pyrimidine-containing compound transmembrane transport is a
sterol transmembrane transport is a
transmembrane transporter activity part of
urea transmembrane transport is a
vacuolar transmembrane transport is a
vitamin transmembrane transport is a
transposition is a
vacuolar transport is a
vesicle-mediated transport is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
cell is a
cellular anatomical entity is a
A band is a727 BRENDA localization in branch, click for list of all
acroblast is a
acrosomal matrix is a724 BRENDA localization in branch, click for list of all
actin body is a
actin cap is a723 BRENDA localization in branch, click for list of all
actin filament branch point is a
actin filament bundle is a
actin fusion focus is a
actin wave is a
actomyosin is a717 BRENDA localization in branch, click for list of all
actomyosin contractile ring, distal actin filament layer is a
actomyosin contractile ring, intermediate layer is a
actomyosin contractile ring, proximal layer is a
alae of collagen and cuticulin-based cuticle extracellular matrix is a
annular furrow extracellular matrix is a
annuli extracellular matrix is a
apical complex is a716 BRENDA localization in branch, click for list of all
apical cytoplasm is a
apical lamina of hyaline layer is a
apical part of cell is a711 BRENDA localization in branch, click for list of all
ascus epiplasm is a
assemblon is a
axon collateral is a709 BRENDA localization in branch, click for list of all
axon hillock is a708 BRENDA localization in branch, click for list of all
axon initial segment is a707 BRENDA localization in branch, click for list of all
axonemal basal plate is a
axonemal central apparatus is a
axonemal outer doublet is a702 BRENDA localization in branch, click for list of all
axoneme is a701 BRENDA localization in branch, click for list of all
bacterial biofilm matrix surface is a
bacterial-type flagellum basal body is a
bacterial-type flagellum filament is a
bacterial-type flagellum hook is a
bacterial-type flagellum hook-filament junction is a
basal labyrinth is a
basal layer of collagen and cuticulin-based cuticle extracellular matrix is a
basal part of cell is a
basolateral cytoplasm is a
bilobe structure is a
blood microparticle is a
Casparian strip is a
cell body is a696 BRENDA localization in branch, click for list of all
cell division site is a693 BRENDA localization in branch, click for list of all
cell junction is a688 BRENDA localization in branch, click for list of all
cell leading edge is a
cell periphery is a651 BRENDA localization in branch, click for list of all
cell cortex part of38 BRENDA localization in branch, click for list of all
external encapsulating structure part of25 BRENDA localization in branch, click for list of all
cell outer membrane part of
cell wall is a23 BRENDA localization in branch, click for list of all
cyst wall is a10 BRENDA localization in branch, click for list of all
external side of cell wall part of
filiform apparatus part of
fungal-type cell wall is a
peptidoglycan-based cell wall is a8 BRENDA localization in branch, click for list of all
perforation plate part of
plant-type cell wall is a
cellulose microfibril part of2 BRENDA localization in branch, click for list of all
primary cell wall is a1 BRENDA localization in branch, click for list of all
secondary cell wall is a
sieve area part of4 BRENDA localization in branch, click for list of all
spore wall is a3 BRENDA localization in branch, click for list of all
structural constituent of cell wall
egg chorion is a
egg coat is a10 BRENDA localization in branch, click for list of all
glycocalyx is a7 BRENDA localization in branch, click for list of all
pollen wall is a4 BRENDA localization in branch, click for list of all
S-layer is a
plasma membrane part of611 BRENDA localization in branch, click for list of all
cell plate is a476 BRENDA localization in branch, click for list of all
cell pole is a475 BRENDA localization in branch, click for list of all
cell projection is a
cell septum is a468 BRENDA localization in branch, click for list of all
cell surface is a467 BRENDA localization in branch, click for list of all
cell tip is a
cell trailing edge is a
cellular bud is a
central element is a465 BRENDA localization in branch, click for list of all
central plaque of spindle pole body is a
centriolar satellite is a
centrosomal corona is a
chiasma is a464 BRENDA localization in branch, click for list of all
chromatin is a463 BRENDA localization in branch, click for list of all
chromosomal region is a446 BRENDA localization in branch, click for list of all
cnida is a
compact myelin is a440 BRENDA localization in branch, click for list of all
concave side of sperm head is a
cone matrix sheath is a
contractile ring is a439 BRENDA localization in branch, click for list of all
cortical layer of collagen and cuticulin-based cuticle extracellular matrix is a
costamere is a
cytoophidium is a438 BRENDA localization in branch, click for list of all
cytoplasm is a437 BRENDA localization in branch, click for list of all
deep fiber is a
dense fibrillar component is a250 BRENDA localization in branch, click for list of all
dense nuclear body is a
dinoflagellate antapex is a
dinoflagellate apex is a
dinoflagellate epicone is a
dinoflagellate hypocone is a
DNA replication termination region is a
eisosome is a249 BRENDA localization in branch, click for list of all
endonuclear canal is a248 BRENDA localization in branch, click for list of all
endospore core is a
ensheathing process is a
envelope is a247 BRENDA localization in branch, click for list of all
epicuticle of collagen and cuticulin-based cuticle extracellular matrix is a
extracellular matrix is a246 BRENDA localization in branch, click for list of all
extracellular region is a230 BRENDA localization in branch, click for list of all
extrachromosomal circular DNA is a212 BRENDA localization in branch, click for list of all
extrachromosomal DNA is a211 BRENDA localization in branch, click for list of all
extrinsic component of membrane is a
fibrillar center is a
Flemming body is a
gas vesicle shell is a
germ tube is a209 BRENDA localization in branch, click for list of all
granular component is a208 BRENDA localization in branch, click for list of all
half bridge of spindle pole body is a
host cellular component is a
incipient cellular bud site is a
inclusion body is a193 BRENDA localization in branch, click for list of all
inner membrane pellicle complex is a
inner plaque of spindle pole body is a
intermediate layer of spindle pole body is a
intracellular immature spore is a
intrinsic component of membrane is a
investment cone is a
lateral element is a
lateral loop is a
lateral part of cell is a
leaflet of membrane bilayer is a
manchette is a183 BRENDA localization in branch, click for list of all
median body is a
membrane is a182 BRENDA localization in branch, click for list of all
membrane-enclosed lumen is a
metaphase plate is a119 BRENDA localization in branch, click for list of all
microtubule bundle is a
microtubule end is a118 BRENDA localization in branch, click for list of all
microtubule organizing center is a116 BRENDA localization in branch, click for list of all
midbody is a107 BRENDA localization in branch, click for list of all
myelin sheath is a106 BRENDA localization in branch, click for list of all
neck portion of tanycyte is a
nucleoid is a105 BRENDA localization in branch, click for list of all
nucleus lagging edge is a
nucleus leading edge is a
oral apparatus is a103 BRENDA localization in branch, click for list of all
organelle is a102 BRENDA localization in branch, click for list of all
pellicle is a10 BRENDA localization in branch, click for list of all
periplasmic space is a9 BRENDA localization in branch, click for list of all
photoreceptor inner segment is a8 BRENDA localization in branch, click for list of all
polar tube is a7 BRENDA localization in branch, click for list of all
site of polarized growth is a6 BRENDA localization in branch, click for list of all
somatodendritic compartment is a
sperm head is a5 BRENDA localization in branch, click for list of all
sperm head-tail coupling apparatus is a
sporoplasm is a
subapical part of cell is a
supramolecular complex is a4 BRENDA localization in branch, click for list of all
symplast is a3 BRENDA localization in branch, click for list of all
tail portion of tanycyte is a
thylakoid is a2 BRENDA localization in branch, click for list of all
Yb body is a
intracellular is a81 BRENDA localization in branch, click for list of all
other organism part is a
protein-containing complex is a55 BRENDA localization in branch, click for list of all
virion is a9 BRENDA localization in branch, click for list of all
molecular_function is a