Gene ontology ID
GO:0036130
Definition
Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)
Synonyms
1. PGH2 9,11-endoperoxidase
2. PGH2 9-,11-endoperoxide reductase
References
1. GOC: mw
2. KEGG REACTION: R02264
3. PMID 106227214. PMID 149797155. PMID 164757876. Reactome: R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3"
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tissue/ enzyme/ localization link to BRENDA