Literature summary for 6.3.2.2 extracted from

Botta, D.; Franklin, C.C.; White, C.C.; Krejsa, C.M.; Dabrowski, M.J.; Pierce, R.H.; Fausto, N.; Kavanagh, T.J.
Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis (2004), Free Radic. Biol. Med., 37, 632-642.

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Cloned(Commentary)

Cloned (Comment)	Organism
Hepa-1 cells transfected with GCLC (catalytic subunit) and GCLM (modifier subunit) expression vectors	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-glutamate + L-cysteine	Mus musculus	rate-limiting enzyme in GSH synthesis. Overexpression of the catalytic and modifier subunits of the enzyme leads to enhanced GCL activity and resistance to TNF-induced apoptosis. Maintenance of mitochondrial integrity is a major mechanism of protection against TNF-induced apoptosis in Hepa-1 cells overexpressing the enzyme	ADP + phosphate + gamma-L-glutamyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + L-cysteine	rate-limiting enzyme in GSH synthesis. Overexpression of the catalytic and modifier subunits of the enzyme leads to enhanced GCL activity and resistance to TNF-induced apoptosis. Maintenance of mitochondrial integrity is a major mechanism of protection against TNF-induced apoptosis in Hepa-1 cells overexpressing the enzyme	Mus musculus	ADP + phosphate + gamma-L-glutamyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
GCL	-	Mus musculus
glutamate-cysteine ligase	-	Mus musculus

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Release 2023.1 (January 2023)