Activating Compound | Comment | Organism | Structure |
---|---|---|---|
mcCDC34 | an ubiquitine conjugated protein, induces gamma-glutamylcysteine synthetase expression only in glutathione synthetase-dficient mutants, not in the wild-type | Saccharomyces cerevisiae |
Cloned (Comment) | Organism |
---|---|
expression of the enzyme at high level in deletion mutant strains of GHS1 and GSH2, the latter encoding the glutathione synthetase, the GSH1 promotor is Met4-inducible and GSH repressible | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutants with a deletion of GSH1 cannot grow, a high level expression from a plasmid of the enzyme can compensate for adeletion of gene GSH2 encoding glutathione synthatase, the enzyme catalyzing the second step of glutathione biosynthesis | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GSH | regulatory function, represses expression of GSH1 gene | Saccharomyces cerevisiae | |
methionine | inhibits induction of GSH1 expression, independently of GSH | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | Saccharomyces cerevisiae | - |
ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
additional information | Saccharomyces cerevisiae | Met4 regulates the GSH1 expression in response to GSH availability, model for genetic regulation and control of GSH biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
gene GSH1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | - |
Saccharomyces cerevisiae | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
additional information | Met4 regulates the GSH1 expression in response to GSH availability, model for genetic regulation and control of GSH biosynthesis | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-Glutamylcysteine synthetase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae |