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Literature summary for 5.4.4.7 extracted from

  • Yu, Z.; Schneider, C.; Boeglin, W.E.; Marnett, L.J.; Brash, A.R.
    The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase (2003), Proc. Natl. Acad. Sci. USA, 100, 9162-9167.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ contains Fe2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(12R)-HPETE preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 ratio ?
(12S)-HPETE
-
 Homo sapiens (10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid
-
 ?
(15S)-HPETE
-
 Homo sapiens 15-oxoeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
-
 ?
(8R)-HPETE
-
 Homo sapiens ?
-
 ?
additional information linoleic, arachidonic, and eicosapentaenoic acids, the methyl esters of arachidonic acid and linoleic acid, arachidonyl phosphatidylcholine, anandamide, and the cholesteryl ester of arachidonic acid are no substrates Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ALOXE3
-
 Homo sapiens
eLOX3
-
 Homo sapiens
epidermal LOX type 3
-
 Homo sapiens