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Literature summary for 5.3.1.8 extracted from
- Purification and characterization of fungal and mammalian phosphomannose isomerases (1994), J. Protein Chem., 13, 619-627.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Candida albicans |  |
| 1,10-phenanthroline | - |
Homo sapiens | |
| 1,10-phenanthroline | - |
Saccharomyces cerevisiae | |
| 1,10-phenanthroline | - |
Sus scrofa | |
| arabinose 5-phosphate | - |
Candida albicans | |
| arabinose 5-phosphate | - |
Homo sapiens | |
| arabinose 5-phosphate | - |
Saccharomyces cerevisiae | |
| arabinose 5-phosphate | - |
Sus scrofa | |
| dithiothreitol | - |
Candida albicans | |
| dithiothreitol | - |
Homo sapiens | |
| dithiothreitol | - |
Saccharomyces cerevisiae | |
| dithiothreitol | - |
Sus scrofa | |
| EDTA | - |
Candida albicans | |
| EDTA | - |
Homo sapiens | |
| EDTA | - |
Saccharomyces cerevisiae | |
| EDTA | - |
Sus scrofa | |
| erythrose 4-phosphate | - |
Candida albicans | |
| erythrose 4-phosphate | - |
Homo sapiens | |
| erythrose 4-phosphate | - |
Saccharomyces cerevisiae | |
| erythrose 4-phosphate | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
mannose 6-phosphate | - |
Sus scrofa | |
| 0.25 | - |
mannose 6-phosphate | wild-type enzyme | Homo sapiens | |
| 0.65 | - |
mannose 6-phosphate | - |
Saccharomyces cerevisiae | |
| 1.24 | - |
mannose 6-phosphate | - |
Candida albicans | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | - |
Saccharomyces cerevisiae | |
| Zinc | recombinant enzyme expressed in E. coli contains slightly less than 1 mol of zinc per mol of proteins | Homo sapiens | |
| Zinc | recombinant enzyme expressed in E. coli contains slightly less than 1 mol of zinc per mol of proteins | Candida albicans | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Sus scrofa |
- |
Saccharomyces cerevisiae |
- |
Candida albicans |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 75 | - |
- |
Homo sapiens |
| 80 | - |
- |
Sus scrofa |
| 380 | - |
- |
Candida albicans |
| 420 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Mannose 6-phosphate | - |
Homo sapiens | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Sus scrofa | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Saccharomyces cerevisiae | D-Fructose 6-phosphate | - |
? | |
| D-Mannose 6-phosphate | - |
Candida albicans | D-Fructose 6-phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8 | - |
Homo sapiens |
| 6.5 | 8 | - |
Sus scrofa |
| 6.5 | 8 | - |
Saccharomyces cerevisiae |
| 6.5 | 8 | - |
Candida albicans |
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