Literature summary for 4.6.1.25 extracted from

Sanson, B.; Uzan, M.
Post-transcriptional controls in bacteriophage T4 roles of the sequence-specific endoribonuclease RegB (1995), FEMS Microbiol. Rev., 17, 141-150 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
a [pre-mRNA]-containing guanosine-adenosine + H2O	Tequatrovirus T4	-	a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	P13312	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
a [pre-mRNA]-containing guanosine-adenosine + H2O	-	Tequatrovirus T4	a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate	-	?
a [pre-mRNA]-containing guanosine-adenosine + H2O	the sequence-specific endoribonuelease RegB introduces cuts in early phage messenger RNAs. In most cases, cutting takes place in the middle of the tetranacleotide GGAG. Efficient cleavages occur in the motifs located in intergenic regions, some of them being Shine-Dalgamo sequences. When located in a coding sequence, this tetranucleotide is poorly recognized or not at all	Tequatrovirus T4	a 5' hydroxy-guanosine-[pre-mRNA fragment] + a [pre-mRNA fragment]-3'-adenosine-3'-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
RegB	-	Tequatrovirus T4

General Information

General Information	Comment	Organism
physiological function	inactivates a sub-class of early mRNA by cleaving Shine-Dalgamo sequences, and (ii) it is necessary for the degradation of early mRNAs, but not of middle and late mRNAs	Tequatrovirus T4

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Release 2023.1 (January 2023)