Literature summary for 4.6.1.2 extracted from

Dhaese, I.; Vanneste, G.; Sips, P.; Buys, E.S.; Brouckaert, P.; Lefebvre, R.A.
Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice) (2008), Naunyn Schmiedebergs Arch. Pharmacol., 379, 473-487.

Search for more literature for 4.6.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
NO	activates the sGCalpha2beta1 enzyme and induces muscle relaxation after electric field stimulation	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
the sGCalpha1 gene encodes for an essential part of the catalytic domain. Quantitative expression analysis by RT-PCR and relative levels of alpha1, alpha2, and beta1 subunit mRNA in male KO tissues versus male wild-type tissues	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of sGCalpha1 subunit KO mice, that show abolished muscle relaxation after electric field stimulation more pronounced in female than in male KO mice	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Mus musculus	role of sGCalpha1beta1 in nitrergic regulation of jejunal smooth muscle activity in male and female mice, overview	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	female and male Swiss/129 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Mus musculus	-
jejunum	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	cGMP production in wild-type and sGCalpha1 KO mice	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Mus musculus	3',5'-cyclic GMP + diphosphate	-	?
GTP	role of sGCalpha1beta1 in nitrergic regulation of jejunal smooth muscle activity in male and female mice, overview	Mus musculus	3',5'-cyclic GMP + diphosphate	-	?

Subunits

Subunits	Comment	Organism
heterodimer	alphabeta heterodimer, the sGCalpha1 subunit harbors an essential part of the catalytic domain	Mus musculus

Synonyms

Synonyms	Comment	Organism
sGC	-	Mus musculus
sGCalpha2beta1	-	Mus musculus
soluble guanylate cyclase	-	Mus musculus

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Release 2023.1 (January 2023)