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Literature summary for 4.6.1.2 extracted from

  • Jankowska, A.; Burczy?ska, B.; Duda, T.; Warchol, J.B.
    Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm (2008), Fertil. Steril., 93, 904-912.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ modulates the membrane guanylate cyclase transduction machinery by both inhibiting and stimulating it involving the guanylate cyclae, the guanylate cyclase activating protein type 1, S100B, and neurocalcin delta, mechanism, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane rod outer segment membrane Homo sapiens 16020
-
photoreceptor outer segment
-
 Homo sapiens 1750
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ modulates the membrane guanylate cyclase transduction machinery by both inhibiting and stimulating it involving the guanylate cyclae, the guanylate cyclase activating protein type 1, S100B, and neurocalcin delta, mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens the membrane guanylate cyclase is part of a transduction machinery involving the guanylate cyclae, the guanylate cyclase activating protein type 1, S100B, and neurocalcin delta, mechanism, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal rod ROS-GC1 Homo sapiens
-
sperm
-
 Homo sapiens
-
spermatozoon
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP the membrane guanylate cyclase is part of a transduction machinery involving the guanylate cyclae, the guanylate cyclase activating protein type 1, S100B, and neurocalcin delta, mechanism, overview Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
rod outer segment membrane guanylate cyclase type 1
-
 Homo sapiens
ROS-GC1
-
 Homo sapiens