Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3-morpholinosydnonimine | i.e. SIN-1 | Mus musculus | |
BAY 41-2272 | - |
Mus musculus | |
H2O2 | activates the enzyme, and reduces the cGMP formation activation by nitroprusside and BAY 41-2272 in smooth muscle cells, but enhances the response to HMR-1766, the activation by reactive oxigen species is heme-dependent | Mus musculus | |
HMR-1766 | stimulates the enzyme, especially heme-free sGC, identification of the interaction region and binding structure of the enzyme by computational modelling | Mus musculus | |
menadione | - |
Mus musculus | |
nitroprusside | - |
Mus musculus | |
rotenone | - |
Mus musculus | |
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | potentiates the activating effect of HMR-1766 on the wild-type enzyme | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of the heme-free alpha1-subunit/H105F beta1-subunit sGC mutant in COS-7 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
H105F | the enzyme of heme-free alpha1-subunit/H105F beta1-subunit sGC mutant is not activated by sodium nitroprusside, but by HMR-1766, 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one does not potentiate the activating effect of HMR-1766 in mutant cells, while it does in wild-type cells, binding structure of H105F mutant with HMR-1766, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | inhibits the enzyme and the enzyme activating effect of sodium nitroprusside | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Mus musculus |
soluble guanylyl cyclase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus |