Literature summary for 4.4.1.11 extracted from

Morozova, E.A.; Anufrieva, N.V.; Davydov, D.Z.; Komarova, M.V.; Dyakov, I.N.; Rodionov, A.N.; Demidkina, T.V.; Pokrovsky, V.S.
Plasma methionine depletion and pharmacokinetic properties in mice of methionine gamma-lyase from Citrobacter freundii, Clostridium tetani and Clostridium sporogenes (2017), Biomed. Pharmacother., 88, 978-984 .

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Application

Application	Comment	Organism
medicine	mice plasma methionine decreases to undetectable level 10 min after methionine gamma lyase 1000 U/kg injection. The enzyme shows a pharmakokinetic half-life of 0.76 h	Clostridium tetani
medicine	mice plasma methionine decreases to undetectable level 10 min after methionine gamma lyase 1000 U/kg injection. The enzyme shows a pharmakokinetic half-life of 0.91 h	Clostridium sporogenes
medicine	mice plasma methionine decreases to undetectable level 10 min after methionine gamma lyase 1000 U/kg injection. The enzyme shows a pharmakokinetic half-life of 1.69 h	Citrobacter freundii

Organism

Organism	UniProt	Comment	Textmining
Citrobacter freundii	Q84AR1	-	-
Clostridium sporogenes	J7TA22	-	-
Clostridium sporogenes ATCC 15579	J7TA22	-	-
Clostridium tetani	A0A1L7H888	-	-

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Release 2023.1 (January 2023)