Information on EC 4.4.1.11 - methionine gamma-lyase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
4.4.1.11
-
RECOMMENDED NAME
GeneOntology No.
methionine gamma-lyase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
elimination
-
-
alpha,gamma and alpha,beta-elimination; gamma-replacement; of H2S or RSH, C-S bond cleavage
-
PATHWAY
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
-
Selenocompound metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)
A pyridoxal-phosphate protein.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
EhMGL1
Q86D28
methionine gamma-lyase isoenzyme 1
EhMGL2
Q86D27
methionine gamma-lyase isoenzyme 2
Fn1419
Fusobacterium nucleatum subsp. nucleatum, ATCC 25586
Q8RDT4
-
-
L-methionase
-
-
L-methionase
-
-
L-methioninase
-
-
-
-
L-methioninase
Achromobacter starkeyi, Aeromonas sp.
-
-
L-methioninase
-
-
L-methioninase
-
-
L-methioninase
-
-
L-methioninase
Aspergillus sp. Rs-1a
-
-
-
L-methioninase
-
-
L-methioninase
-
-
L-methioninase
-
-
L-methioninase
-
-
L-methionine gamma-lyase
-
-
-
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase
Q84AR1
-
L-methionine gamma-lyase
Citrobacter freundii ATCC29063
Q84AR1
-
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase 1
Q86D28
-
L-methionine-alpha-deamino-gamma-mercaptomethane lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-gamma-lyase
-
-
L-methionine-gamma-lyase
Fusobacterium nucleatum JCM8532
-
-
-
L-methionine-gamma-lyase
-
-
L-methionine-gamma-lyase
-
-
-
L-methionine-gamma-lyase
-
-
L-methionine-gamma-lyase
Treponema denticola ATCC35405
-
-
-
lyase, methionine
-
-
-
-
methioninase
-
-
-
-
methioninase
-
-
methioninase
Fusobacterium nucleatum JCM8532
-
-
-
methioninase
-
-
methioninase
-
-
methioninase
-
-
-
methioninase
-
-
methioninase
Treponema denticola ATCC35405
-
-
-
methionine alpha,gamma-lyase
-
-
methionine dethiomethylase
-
-
-
-
methionine gamma-lyase
-
-
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
Q9SGU9
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
O15564, O15565
-
methionine lyase
-
-
-
-
methionine-gamma-lyase
Q5MQ31
-
methionine-gamma-lyase
-
-
MGL
Citrobacter freundii ATCC29063
Q84AR1
-
-
TvMGL1
O15564
-
TvMGL2
O15565
-
YtjE
Lactococcus lactis IL1403
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
42616-25-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Achromobacter starkeyi
-
-
-
Manually annotated by BRENDA team
expression of enzyme is induced in response to high methionine levels
-
-
Manually annotated by BRENDA team
variant Aspergillus flavus columnaris
-
-
Manually annotated by BRENDA team
Aspergillus sp. Rs-1a
-
-
-
Manually annotated by BRENDA team
ATCC 9175
SwissProt
Manually annotated by BRENDA team
ATCC29063
SwissProt
Manually annotated by BRENDA team
Citrobacter freundii ATCC29063
ATCC29063
SwissProt
Manually annotated by BRENDA team
isoenzyme 1
SwissProt
Manually annotated by BRENDA team
isoenzyme 2
SwissProt
Manually annotated by BRENDA team
isoform ehMGL1
SwissProt
Manually annotated by BRENDA team
isoform ehMGL2
SwissProt
Manually annotated by BRENDA team
strain JCM8532
-
-
Manually annotated by BRENDA team
Fusobacterium nucleatum JCM8532
strain JCM8532
-
-
Manually annotated by BRENDA team
Fusobacterium nucleatum subsp. nucleatum, ATCC 25586
-
UniProt
Manually annotated by BRENDA team
strain IL1403
-
-
Manually annotated by BRENDA team
Lactococcus lactis IL1403
strain IL1403
-
-
Manually annotated by BRENDA team
commercial product
-
-
Manually annotated by BRENDA team
no activity in mammalia
-
-
-
Manually annotated by BRENDA team
black-pigmented anaerobe strongly implicated as a major pathogen in adult periodontitis, growth of Porphyromonas gingivalis is inhibited by L-trifluoromethionine
-
-
Manually annotated by BRENDA team
strain PAO1
-
-
Manually annotated by BRENDA team
strain S-313
-
-
Manually annotated by BRENDA team
Pseudomonas putida S-313
strain S-313
-
-
Manually annotated by BRENDA team
ATCC 35405
-
-
Manually annotated by BRENDA team
strain ATCC35405
-
-
Manually annotated by BRENDA team
Treponema denticola ATCC35405
strain ATCC35405
-
-
Manually annotated by BRENDA team
additional information
-
-
-
Manually annotated by BRENDA team
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Cd2+
-
significant enzyme inhibition
Cd2+
-
inhibitor
Co2+
-
slightly stimulatory effect on the enzyme activity
Co2+
-
increased enzyme activity after preincubation of the enzyme for 2 h
Cu2+
-
slightly stimulatory effect on the enzyme activity
Cu2+
-
increased enzyme activity after preincubation of the enzyme for 2 h
Li+
-
significant enzyme inhibition
Li+
-
inhibitor
Mg2+
-
slightly stimulatory effect on the enzyme activity
Mg2+
-
increased enzyme activity after preincubation of the enzyme for 2 h
Mn2+
-
slightly stimulatory effect on the enzyme activity
Mn2+
-
increased enzyme activity after preincubation of the enzyme for 2 h
Na+
-
significant enzyme inhibition
Ni2+
-
slightly stimulatory effect on the enzyme activity
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.035
-
DL-propargylglycine
Q86D27, Q86D28
-
49
-
glycine
-
pH 8.0, 30C
8.3
-
L-2-aminobutanoate
-
pH 8.0, 30C
3.4
-
L-alanine
-
pH 8.0, 30C
0.6
-
L-Norleucine
-
pH 8.0, 30C
4.7
-
L-norvaline
-
pH 8.0, 30C
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.9
-
Q86D27, Q86D28
two-dimensional PAGE, recombinant EhMGL1
6
-
Q86D27, Q86D28
two-dimensional PAGE, native EhMGL1
6.5
-
Q86D27, Q86D28
two-dimensional PAGE, recombinant EhMGL2
6.7
-
Q86D27, Q86D28
two-dimensional PAGE, native EhMGL2
PDB
SCOP
CATH
ORGANISM