Literature summary for 4.2.1.118 extracted from

Lamb, H.K.; Van den Hombergh, J.P.T.W.; Newton, G.H.; Moore, J.D.; Roberts, C.F.; Hawkins, A.R.
Differential flux through the quinate and shikimate pathways. Implications for the channeling hypothesis (1992), Biochem. J., 284, 181-187.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in Aspergillus nidulans	Aspergillus nidulans

Organism

Organism	UniProt	Comment	Textmining
Aspergillus nidulans	-	-	-

Synonyms

Synonyms	Comment	Organism
QutC	-	Aspergillus nidulans

General Information

General Information	Comment	Organism
physiological function	constitutve overexpression leads to impaired growth in minimal medium which can be alleviated by the addition of aromatic amino acids to the medium. Overexpression of the qutC gene in mutant strains lacking protocatechuic acid oxygenase leads to the build up of protocatechuic acid in the medium. The metabolites 3-dehydroquinate and dehydroshikimate leak from the pentafunctional AROM protein at a rate comparable with the extent of flux catalysed by the AROM protein. The AROM protein has a low level channelling function probably as a result of the close juxtaposition of five active sites and this channelling function is only physiologically significant under non-optimal conditions of nutrient supply and oxygenation, when the organism is in situ in its natural environment	Aspergillus nidulans

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Release 2023.1 (January 2023)