Cloned (Comment) | Organism |
---|---|
expressed in Amdc-s cells (NIH3T3 cells transfected with human AdoMetDC cDNA) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CGP 48664 | specific inhibitor of AdoMetDC | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
fibrosarcoma cell | - |
Homo sapiens | - |
HT-1080 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
AdoMetDC | - |
Homo sapiens |
S-Adenosylmethionine decarboxylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts leads to aggressive transformants (Amdc-s cells) that have high invasive capacity in nude mice, invading rapidly from the subcutaneous injection site into the peritoneal cavity and its organs. Amdc-s-induced tumors show chaotic neovascularization, with abundant pleomorphic vessel-like structures that have noncontiguous or totally missing laminin (basement membrane) and CD31 (endothelial cell) immunoreactivity | Homo sapiens |
physiological function | S-adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of polyamines essential for cell proliferation | Homo sapiens |