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Literature summary for 3.5.1.92 extracted from

  • Kavian, N.; Mehlal, S.; Marut, W.; Servettaz, A.; Giessner, C.; Bourges, C.; Nicco, C.; Chereau, C.; Lemarechal, H.; Dutilh, M.F.; Cerles, O.; Guilpain, P.; Vuiblet, V.; Chouzenoux, S.; Galland, F.; Quere, I.; Weill, B.; Naquet, P.; Batteux, F.
    Imbalance of the vanin-1 pathway in systemic sclerosis (2016), J. Immunol., 197, 3326-3335 .
    View publication on PubMed
Search for more literature for 3.5.1.92

Application

Application Comment Organism
diagnostics potential use of vanin-1 as a marker of severity and therapeutic target in systemic sclerosis (SSc) Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane vanin-1 is a ubiquitous membrane-bound enzyme Mus musculus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-pantetheine + H2O Mus musculus
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 (R)-pantothenate + 2-aminoethanethiol
-
 ?
(R)-pantetheine + H2O Mus musculus BALB/c
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 (R)-pantothenate + 2-aminoethanethiol
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z0K8
-
-
Mus musculus BALB/c Q9Z0K8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast primary Mus musculus
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skin
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-pantetheine + H2O
-
 Mus musculus (R)-pantothenate + 2-aminoethanethiol
-
 ?
(R)-pantetheine + H2O
-
 Mus musculus BALB/c (R)-pantothenate + 2-aminoethanethiol
-
 ?

Synonyms

Synonyms Comment Organism
pantetheinase
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 Mus musculus
vanin-1
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 Mus musculus
VNN1
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 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus inactivation of vnn1 on the development of fibrosis, endothelial alterations, and immunological activation in mice with HOCl- and bleomycin-induced systemic sclerosis (SSc) additional information

General Information

General Information Comment Organism
malfunction evaluation of the effects of the inactivation of vnn1 on the development of fibrosis, endothelial alterations, and immunological activation in mice with HOCl- and bleomycin-induced systemic sclerosis (SSc). The vanin-1/pantetheinase pathway is activated in wild-type BALB/c mice through hypochlorous acid (HOCl)-induced SSc. Hyperactivity of the vanin-1/pantetheinase pathway may reduce the vasculoprotective effects of pantethine, while genetic inactivation of vanin-1 has a protective effect Mus musculus
metabolism inactivation of vnn1 on the development of fibrosis, endothelial alterations, and immunological activation in mice with HOCl- and bleomycin-induced systemic sclerosis (SSc) Mus musculus
physiological function the vanin-1 gene (vnn1) encodes an enzyme with pantetheinase activity that converts vasculoprotective pantethine into profibrotic pantothenic acid and pro-oxidant cystamine. By hydrolyzation of pantethine, vanin-1 delivers cysteamine and pantothenic acid to tissues. Cysteamine is rapidly converted into cystamine that can regulate the function of other target proteins by a disulfide reaction. In particular, cystamine abrogates glutathione (GSH) production by inhibiting gamma-glutamyl synthase, the rate-limiting enzyme of GSH synthesis, thus strongly reducing reactive oxygen species (ROS) scavenging. In contrast, pantothenic acid, the other by-product of vanin-1, exerts profibrotic effects by promoting the proliferation and migration of dermal fibroblasts, as well as collagen synthesis Mus musculus