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Literature summary for 3.5.1.92 extracted from

  • Lin, Y.; Gao, Y.; Ma, Z.; Li, Z.; Tang, C.; Qin, X.; Zhang, Z.; Wang, G.; Du, L.; Li, M.
    Bioluminescent probe for detection of starvation-induced pantetheinase upregulation (2018), Anal. Chem., 90, 9545-9550 .
    View publication on PubMed
Search for more literature for 3.5.1.92

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics and Lineweaver-Burk plots Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z0K8
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-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Mus musculus
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kidney
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 Mus musculus
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liver
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 Mus musculus
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additional information pantetheinase is a glycosylphosphatidylinositol (GPI) anchored enzyme, overexpressed in intestine, liver, and kidney Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(6-[[N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanyl]amino]-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-5-carboxylic acid + H2O design, synthesis, and biological examination of a highly sensitive bioluminogenic probe for pantetheinase with a limit of detection of 1.14 ng/ml. Validation of the probe for application to detect the endogenous pantetheinase activity, overview Mus musculus 2-(6-amino-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-5-carboxylic acid + N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanine
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 ir

Synonyms

Synonyms Comment Organism
pantetheinase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus starvation-induced pantetheinase upregulation up

General Information

General Information Comment Organism
physiological function pantetheinase is a glycosylphosphatidylinositol (GPI) anchored enzyme, overexpressed in intestine, liver, and kidney with various biological functions such as its linkage to the inflammation and some metabolic diseases. It can hydrolyze pantetheine to cysteamine, an antioxidant, and pantothenic acid (vitamin B5) that is an essential component of coenzyme A (CoA). Starvation induces pantetheinase upregulation Mus musculus