Cloned (Comment) | Organism |
---|---|
gene Vnn1, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
gene Vnn1, quantitative RT-PCR enzyme expression analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95497 | Malaria diagnosed children living in Luanda (Angola) ranging from 6 months to 13 years of age | - |
Mus musculus | Q9Z0K8 | mice injected i.p. with 106 Plasmodium berghei ANKA infected red blood cells | - |
Mus musculus C57BL/6 | Q9Z0K8 | mice injected i.p. with 106 Plasmodium berghei ANKA infected red blood cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
serum | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
comparisons of healthy with Malaria red blood cells | Homo sapiens |
additional information | - |
comparisons of healthy with Malaria red blood cells | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
pantetheinase | - |
Homo sapiens |
pantetheinase | - |
Mus musculus |
VNN1 | - |
Homo sapiens |
VNN1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mutant mice with a reduced serum pantetheinase activity are anemic and prone to phenylhydrazine-induced anemia. A cytofluorometric and spectroscopic analysis documents an increased frequency of erythrocytes with an autofluorescent aging phenotype. This is associated with an enhanced oxidative stress and shear stress-induced hemolysis. Red blood cell transfer and bone marrow chimera experiments show that the aging phenotype is not cell intrinsic but conferred by the environment, leading to a shortening of red blood cell half-life. Phenotype analysis, detailed overview | Mus musculus |
metabolism | Malaria enzyme phenotype analysis, detailed overview | Homo sapiens |
physiological function | tissue pantetheinase, encoded by the VNN1 gene, regulates response to stress. VNN genes contribute to the susceptibility to malaria. Serum pantetheinase contributes to erythrocyte resistance to stress under homeostatic conditions. Serum pantetheinase level regulates erythrocyte life span and modulates the risk of developing complicated malaria | Homo sapiens |
physiological function | tissue pantetheinase, encoded by the VNN1 gene, regulates response to stress. VNN genes contribute to the susceptibility to malaria. Serum pantetheinase contributes to erythrocyte resistance to stress under homeostatic conditions. Serum pantetheinase level regulates erythrocyte life span and modulates the risk of developing complicated malaria | Mus musculus |