Application | Comment | Organism |
---|---|---|
medicine | target for the development of new antibacterial drugs | Haemophilus influenzae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxo-pyrrolidine with chelators | - |
Haemophilus influenzae | |
2-thioxo-4-thiazolidinone N-hexanoic acid | IC50 against Escherichia coli peptide deformylase: 0.00166 mM | Haemophilus influenzae | |
actinonin | IC50 against Escherichia coli peptide deformylase: 0.0000003 mM | Haemophilus influenzae | |
aldehyde peptide | IC50 against Escherichia coli peptide deformylase: 0.01 mM | Haemophilus influenzae | |
alkyl-succinate-proline hydroxamate | IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM | Haemophilus influenzae | |
benzimidazole N-formyl hydroxylamine | - |
Haemophilus influenzae | |
benzothiazinone derivatives | IC50: 0.000005 mM | Haemophilus influenzae | |
benzothiazolylidene hydroxamic acid derivatives | IC50 against Escherichia coli peptide deformylase: 0.00104 mM | Haemophilus influenzae | |
beta-sulfonylhydroxamic acid | IC50 against Escherichia coli peptide deformylase: 0.000016 mM | Haemophilus influenzae | |
carbamate N-formyl hydroxylamine | - |
Haemophilus influenzae | |
heteroarylaryl(P2'/P3')N-formyl hydroxylamine | - |
Haemophilus influenzae | |
hydantoin | IC50 against Escherichia coli peptide deformylase: 0.0002 mM | Haemophilus influenzae | |
hydrazide N-formyl hydroxylamine | - |
Haemophilus influenzae | |
isoxazole-3-hydroxamic acid derivatives | IC50 against Escherichia coli peptide deformylase: 0.0034 mM | Haemophilus influenzae | |
N-alkyl urea hydroxamate | IC50 against Escherichia coli peptide deformylase: 0.000003 mM | Haemophilus influenzae | |
N-hydroxy urea | IC50 against Escherichia coli peptide deformylase: 0.0022 mM | Haemophilus influenzae | |
N-hydroxy-2-(substituted phenyl) acetamide | - |
Haemophilus influenzae | |
N-hydroxy-N-(3-hydrazino-3-oxopropyl)formamide | - |
Haemophilus influenzae | |
N-substituted methionine hydrazide | IC50 against Escherichia coli peptide deformylase: 0.2 mM | Haemophilus influenzae | |
N-sulfonyl-L-Val-L-Leu-hydroxamate | - |
Haemophilus influenzae | |
pseudopeptide metabolites | IC50 against Escherichia coli peptide deformylase: 0.000030 mM | Haemophilus influenzae | |
pyrrolidine bicyclic(P2'/P3')compounds | - |
Haemophilus influenzae | |
quinazoline hydroxamic acid | IC50 against Escherichia coli peptide deformylase: 0.00012 mM | Haemophilus influenzae | |
thio peptide | IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif | Haemophilus influenzae | |
thiol peptide | IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified | Haemophilus influenzae | |
thyropropic acid derivatives | IC50 against Escherichia coli peptide deformylase: 0.001 mM | Haemophilus influenzae | |
urea analogs(P2'/P3')of N-formyl hydroxylamine | - |
Haemophilus influenzae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Haemophilus influenzae | |
Ni2+ | - |
Haemophilus influenzae | |
Zn2+ | - |
Haemophilus influenzae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
formyl-L-methionyl peptide + H2O | Haemophilus influenzae | - |
formate + methionyl peptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | - |
- |
- |
Oxidation Stability | Organism |
---|---|
ferrous ion in peptide deformylase is very unstable and is quickly and irreversibly oxidized to the ferric ion under laboratory conditions, resulting in an inactive enzyme. | Haemophilus influenzae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formyl-L-methionyl peptide + H2O | - |
Haemophilus influenzae | formate + methionyl peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
- |
Haemophilus influenzae | |
peptide deformylase | - |
Haemophilus influenzae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000003 | - |
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM | Haemophilus influenzae | actinonin | |
0.000003 | - |
IC50 against Escherichia coli peptide deformylase: 0.000003 mM | Haemophilus influenzae | N-alkyl urea hydroxamate | |
0.000004 | 0.00001 | IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM | Haemophilus influenzae | alkyl-succinate-proline hydroxamate | |
0.000005 | - |
IC50: 0.000005 mM | Haemophilus influenzae | benzothiazinone derivatives | |
0.000016 | - |
IC50 against Escherichia coli peptide deformylase: 0.000016 mM | Haemophilus influenzae | beta-sulfonylhydroxamic acid | |
0.000019 | - |
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif | Haemophilus influenzae | thio peptide | |
0.00003 | - |
IC50 against Escherichia coli peptide deformylase: 0.000030 mM | Haemophilus influenzae | pseudopeptide metabolites | |
0.00012 | - |
IC50 against Escherichia coli peptide deformylase: 0.00012 mM | Haemophilus influenzae | quinazoline hydroxamic acid | |
0.0002 | - |
IC50 against Escherichia coli peptide deformylase: 0.0002 mM | Haemophilus influenzae | hydantoin | |
0.001 | - |
IC50 against Escherichia coli peptide deformylase: 0.001 mM | Haemophilus influenzae | thyropropic acid derivatives | |
0.00104 | - |
IC50 against Escherichia coli peptide deformylase: 0.00104 mM | Haemophilus influenzae | benzothiazolylidene hydroxamic acid derivatives | |
0.00166 | - |
IC50 against Escherichia coli peptide deformylase: 0.00166 mM | Haemophilus influenzae | 2-thioxo-4-thiazolidinone N-hexanoic acid | |
0.0022 | - |
IC50 against Escherichia coli peptide deformylase: 0.0022 mM | Haemophilus influenzae | N-hydroxy urea | |
0.0025 | - |
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified | Haemophilus influenzae | thiol peptide | |
0.0034 | - |
IC50 against Escherichia coli peptide deformylase: 0.0034 mM | Haemophilus influenzae | isoxazole-3-hydroxamic acid derivatives | |
0.01 | - |
IC50 against Escherichia coli peptide deformylase: 0.01 mM | Haemophilus influenzae | aldehyde peptide | |
0.2 | - |
IC50 against Escherichia coli peptide deformylase: 0.2 mM | Haemophilus influenzae | N-substituted methionine hydrazide |