Information on EC 3.5.1.88 - peptide deformylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.5.1.88
-
RECOMMENDED NAME
GeneOntology No.
peptide deformylase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
formyl-L-methionyl peptide + H2O = formate + methionyl peptide
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
deformylation
-
-
deformylation
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
deformylation
-
-
deformylation
-
-
deformylation
;
formylation
-
-
hydrolysis of amide bond
-
-
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
hydrolysis of amide bond
-
-
hydrolysis of amide bond
-
-
SYSTEMATIC NAME
IUBMB Comments
formyl-L-methionyl peptide amidohydrolase
Requires Fe(II). Also requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Differs in substrate specifity from EC 3.5.1.31 (formylmethionine deformylase).
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
AtDEF1.1
-
-
AtDEF1.2
-
-
AtDEF2
-
-
BcPDF2
-
-
deformylase, peptide N-formylmethionine
-
-
-
-
hydrolase, aminoacyl-transfer ribonucleate
-
-
-
-
Ni-peptide deformylase
-
PDF
-
-
-
-
PDF
-
-
PDF
Chlamydia trachomatis GR10
-
-
-
PDF
Staphylococcus aureus ATCC25923, Staphylococcus aureus ATCC29213, Staphylococcus aureus ATCC43300, Staphylococcus aureus Mu50
-
-
-
PDF
Staphylococcus epidermidis ATCC12228
-
-
-
PDF-2
isoform without peptide deformylase activity
PDF1A
-
-
PdfA
Legionella pneumophila Philadelphia 1
-
-
-
PdfB
Legionella pneumophila Philadelphia 1
-
-
-
PdfC
Legionella pneumophila Philadelphia 1
-
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
type I and type II
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase
-
peptide deformylase
-
-
peptide deformylase
Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
peptide deformylase
-
-
peptide deformylase
-
-
peptide deformylase 1
-
-
peptide deformylase 1A
-
peptide deformylase 1B
-
peptide deformylase 2
-
-
Polypeptide deformylase
-
-
-
-
type II peptide deformylase
-
-
CAS REGISTRY NUMBER
COMMENTARY
369636-51-1
-
37289-08-0
-
9032-86-4
-
9054-98-2
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
peptide deformylase 1 and 2
-
-
Manually annotated by BRENDA team
two classes of PDF: PDF1A and PDF1B
-
-
Manually annotated by BRENDA team
harbours two functional peptide deformylase: Def and YkrB. YkrB probably is the predominant deformylase
-
-
Manually annotated by BRENDA team
Chlamydia trachomatis GR10
-
-
-
Manually annotated by BRENDA team
C-terminally truncated recombinant enzyme
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
3D homology model of the matured soybean PDF2 based on the X-ray structure of the homologous enzyme from Plasmodium falciparum
-
-
Manually annotated by BRENDA team
strain SS1
Uniprot
Manually annotated by BRENDA team
strain Philadelphia 1
-
-
Manually annotated by BRENDA team
Legionella pneumophila Philadelphia 1
strain Philadelphia 1
-
-
Manually annotated by BRENDA team
no activity in Caenorhabditis elegans
-
-
-
Manually annotated by BRENDA team
no activity in Saccharomyces cerevisiae
-
-
-
Manually annotated by BRENDA team
; enzyme form 1 and 2
-
-
Manually annotated by BRENDA team
strain ATCC27853
Uniprot
Manually annotated by BRENDA team
two functional deformylases
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa ATCC27853
strain ATCC27853
Uniprot
Manually annotated by BRENDA team
two classes of PDF: PDF1A and PDF1B
-
-
Manually annotated by BRENDA team
strain ATCC2913
Uniprot
Manually annotated by BRENDA team
strain RN4220
Uniprot
Manually annotated by BRENDA team
two functional deformylases
-
-
Manually annotated by BRENDA team
Staphylococcus aureus ATCC25923
-
-
-
Manually annotated by BRENDA team
Staphylococcus aureus ATCC2913
strain ATCC2913
Uniprot
Manually annotated by BRENDA team
Staphylococcus aureus ATCC29213
-
-
-
Manually annotated by BRENDA team
Staphylococcus aureus ATCC43300
-
-
-
Manually annotated by BRENDA team
Staphylococcus aureus Mu50
-
-
-
Manually annotated by BRENDA team
Staphylococcus aureus RN4220
strain RN4220
Uniprot
Manually annotated by BRENDA team
Staphylococcus enteridis
-
-
-
Manually annotated by BRENDA team
isoform PDF-1; strain ATCC35984/RP62A
UniProt
Manually annotated by BRENDA team
isoform PDF-2; strain ATCC35984/RP62A
UniProt
Manually annotated by BRENDA team
Staphylococcus epidermidis ATCC12228
-
-
-
Manually annotated by BRENDA team
Staphylococcus non-hemolyticus
-
-
-
Manually annotated by BRENDA team
strain ATCC6305
Uniprot
Manually annotated by BRENDA team
two functional deformylases
-
-
Manually annotated by BRENDA team
Streptococcus pneumoniae ATCC6305
strain ATCC6305
Uniprot
Manually annotated by BRENDA team
two functional deformylases
-
-
Manually annotated by BRENDA team
strain MSB8
Uniprot
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
-
peptide deformylase (PDF) is a protein of the N-terminal methionine excision pathway that removes formylmethionine from mitochondrial-encoded proteins. PDF is crucial in maintaining mitochondrial function
physiological function
-
PDF is an essential and highly conserved enzyme that functions in protein maturation by removing the N-formyl group from the methionine of nascently synthesized polypeptides
physiological function
-
PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(RS)-phenylalanine nitrile + formate
(S)-N-formyl-phenylalanine nitrile
show the reaction diagram
-
-
99% (S)-enantiomer
r
2-formyloxycaproylleucyl-p-nitroanilide + H2O
?
show the reaction diagram
-
esterase activity, 10fold lower activity compared to N-formyl-Met-Leu-p-nitroanilide
-
-
?
formyl-L-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
-
formyl-L-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
-
formyl-L-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
-
formyl-L-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
formyl-L-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + L-methionyl peptide
show the reaction diagram
-
-
?
formyl-L-methionyl peptide + H2O
formate + L-methionyl peptide
show the reaction diagram
-
peptide deformylase catalyzes the removal of N-terminal formyl groups from nascent ribosome-synthesized polypeptides
-
?
formyl-L-methionyl peptide + H2O
formate + L-methionyl peptide
show the reaction diagram
-
theoretical study of the catalytic mechanism and metal-ion dependence of peptide deformylase
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-MAHA + H2O
formate + MAHA
show the reaction diagram
-
peptide substrate derived from mitochondrial cytochrome c oxidase subunit II
-
?
formyl-MEHQ + H2O
formate + MEHQ
show the reaction diagram
-
-
-
?
formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
substrate activity assay
-
?
formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
Legionella pneumophila Philadelphia 1
-
-
-
?
formyl-Met-Ala-His-Ala + H2O
formate + methionyl-Ala-His-Ala
show the reaction diagram
fMAHA
-
?
formyl-Met-Ala-His-Ala-Ala-Gln + H2O
formate + Met-Ala-His-Ala-Ala-Gln
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Lys-Tyr + H2O
formate + Met-Ala-Lys-Tyr
show the reaction diagram
Legionella pneumophila, Legionella pneumophila Philadelphia 1
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
Legionella pneumophila Philadelphia 1
-
-
-
?
formyl-Met-Ala-Ser + H2O
formate + methionyl-Ala-His-Ala
show the reaction diagram
fMAS
-
?
formyl-Met-Gly-Gly-CH3 + H2O
formate + Met-Gly-Gly-CH3
show the reaction diagram
-
substrate used in QM-MM model
-
?
formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
formyl-Met-Thr-Gln-Ser-His + H2O
formate + Met-Thr-Gln-Ser-His
show the reaction diagram
-
-
-
?
formyl-Met-Thr-Met-His + H2O
formate + methionyl-Thr-Met-His
show the reaction diagram
fMTMH
-
?
formyl-Met-Thr-Met-His-Thr-Thr + H2O
formate + Met-Thr-Met-His-Thr-Thr
show the reaction diagram
-
-
-
?
formyl-Met-Thr-Pro-Met-Arg-Lys + H2O
?
show the reaction diagram
-
-
-
-
?
formyl-MFAD + H2O
formate + MFAD
show the reaction diagram
-
peptide substrate derived from mitochondrial cytochrome c oxidase subunit I
-
?
formyl-MFHQ + H2O
formate + MMFQ
show the reaction diagram
-
-
-
?
formyl-MGHQ + H2O
formate + MGHQ
show the reaction diagram
-
-
-
?
formyl-MLHQ + H2O
formate + MLHQ
show the reaction diagram
-
-
-
?
formyl-MLKL + H2O
formate + MLKL
show the reaction diagram
-
peptide substrate derived from mitochondrial NADH dehydrogenase subunit 4
-
?
formyl-MMYA + H2O
formate + MMYA
show the reaction diagram
-
peptide substrate derived from mitochondrial NADH dehydrogenase subunit 6
-
?
formyl-MNFA + H2O
formate + MNFA
show the reaction diagram
-
peptide substrate derived from mitochondrial NADH dehydrogenase subunit 3
-
?
formyl-MNPL + H2O
formate + MNPL
show the reaction diagram
-
peptide substrate derived from mitochondrial NADH dehydrogenase subunit 2
-
?
formyl-MPQL + H2O
formate + MPQL
show the reaction diagram
-
peptide substrate derived from mitochondrial ATP synthase F0 subunit 8
-
?
formyl-MRHQ + H2O
formate + MRHQ
show the reaction diagram
-
-
-
?
formyl-MTHQ + H2O
formate + MTHQ
show the reaction diagram
-
peptide substrate derived from mitochondrial cytochrome c oxidase subunit III
-
?
formyl-MTMH + H2O
formate + MTMH
show the reaction diagram
-
peptide substrate derived from mitochondrial NADH dehydrogenase subunit 5
-
?
formyl-MTPM + H2O
formate + MTPM
show the reaction diagram
-
peptide substrate derived from mitochondrial cytochrome b
-
?
N-(alpha-difluoroacetyl)-Met-Leu-p-nitroanilide + H2O
difluoroacetic acid + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-(alpha-fluoroacetyl)-Met-Leu-p-nitroanilide + H2O
fluoroacetic acid + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-1-(1-naphthyl)ethylamine + H2O
(1R)-1-naphthalen-1-ylethanamine + formate
show the reaction diagram
-
-
90% (R)-enantiomer
?
N-formyl-3-amino-3-phenylpropionic acid + H2O
(R)-3-amino-3-phenylpropionic acid + formate
show the reaction diagram
-
-
100% (R)-enantiomer
?
N-formyl-Ala-Gly-Ser-Glu + H2O
formate + Ala-Gly-Ser-Glu
show the reaction diagram
-
poor activity, preference of N-terminal methionine
-
?
N-formyl-Ala-Gly-Ser-Glu + H2O
formate + Ala-Gly-Ser-Glu
show the reaction diagram
-
poor activity, preference of N-terminal methionine
-
?
N-formyl-alaninol + H2O
(S)-alaninol + formate
show the reaction diagram
-
-
85.6% (S)-enantiomer
?
N-formyl-alpha-methyl-phenylglycine amide + H2O
(S)-alpha-methyl-phenylglycine amide + formate
show the reaction diagram
-
-
100% (S)-enantiomer
?
N-formyl-beta-thiaphenyl-Lys-p-nitroanilide + H2O
formate + thiophenol + NH3 + Lys-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-beta-thiaphenyl-Lys-p-nitroanilide + H2O
formate + thiophenol + NH3 + Lys-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-beta-thiaphenylalanyl-peptide + H2O
formate + thiophenol + NH3 + alanyl-peptide
show the reaction diagram
-
-
-
?
N-formyl-beta-thiaphenylalanyl-peptide + H2O
formate + thiophenol + NH3 + alanyl-peptide
show the reaction diagram
-
significantly poorer substrate than N-formyl-thiaphenylalanylleucyl-p-nitroanilide
-
?
N-formyl-His-Ala-Ser-Arg + H2O
formate + His-Ala-Ser-Arg
show the reaction diagram
-
greatly attenuated activity, preference for N-terminal methionine
-
?
N-formyl-L-Met-D-Ala-Ser-Arg + H2O
formate + L-Met-D-Ala-Ser-Arg
show the reaction diagram
-
strong requirement for L-methionine, but D-amino acids tolerated in other positions
-
?
N-formyl-L-Met-L-Ala-L-Ser + H2O
formate + L-Met-L-Ala-L-Ser
show the reaction diagram
-
-
?
N-formyl-L-Met-L-Ala-L-Ser + H2O
formate + L-Met-L-Ala-L-Ser
show the reaction diagram
activity assay
-
?
N-formyl-L-Met-L-Leu-4-nitroanilide + H2O
formate + L-Met-L-Leu-4-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-L-Met-Val + H2O
formate + L-Met-Val
show the reaction diagram
-
-
-
?
N-formyl-L-Met-Val + H2O
formate + L-Met-Val
show the reaction diagram
-
-
-
?
N-formyl-L-Met-Val + H2O
formate + L-Met-Val
show the reaction diagram
-
-
-
?
N-formyl-L-Met-Val + H2O
formate + L-Met-Val
show the reaction diagram
-
-
-
?
N-formyl-L-Met-Val + H2O
formate + L-Met-Val
show the reaction diagram
-
-
-
?
N-formyl-L-methionine + H2O
formate + L-methionine
show the reaction diagram
-
worst substrate
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
requires at least a dipeptide as substrate, increasing activity with increasing peptide length until it reaches the tetrapeptide
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
deformylation required for methionine aminopeptidase activity in eubacteria, highly specific
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
deformylase is likely to play an essential role in the chloroplast
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
the enzyme is involved in maturation of proteins by cleaving the N-formyl group from N-blocked methionine polypeptides
-
-
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
essential role in protein processing in plastids
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
the enzyme is requiredfor the removal of the formyl group at the N-terminus of nascent polypeptide chains
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
posttranslational deformylation of N-formyl-Met-polypeptide
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-Nle-L-Ala-L-Ser + H2O
formate + L-Nle-L-Ala-L-Ser
show the reaction diagram
-
norleucine is the only excepted substitution for methionine
-
?
N-formyl-Leu-Tle-NHCH3 + H2O
(S)-Leu-(S)-Tle-NHCH3
show the reaction diagram
-
Tle i.e. tert-leucine
Tle i.e. tert-leucine, 94% (S,S)-diastereomer
?
N-formyl-m-methoxyphenylalanine nitrile + H2O
(S)-m-methoxyphenylalanine nitrile + formate
show the reaction diagram
-
-
99% (S)-enantiomer
?
N-formyl-Met + H2O
formate + Met
show the reaction diagram
-
-
-
?
N-formyl-Met + H2O
formate + Met
show the reaction diagram
-
poor activity
-
?
N-formyl-Met + H2O
formate + Met
show the reaction diagram
-
poor activity
-
?
N-formyl-Met + H2O
formate + Met
show the reaction diagram
-
minimal substrate
-
?
N-formyl-Met + H2O
formate + Met
show the reaction diagram
-
minimal substrate
-
?
N-formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala + H2O
formate + Met-Ala
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala + H2O
Met-Ala + formate
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala(OCH3) + H2O
formate + Met-Ala(OCH3)
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg + H2O
formate + Met-Ala-Phe-Tyr-beta-Ala-Arg
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
best substrate
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
higher activity than compared to di- or tetrapeptides
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
Chlamydia trachomatis GR10
-
-
-
?
N-formyl-Met-Ala-Ser + H2O
formate + Met-Ala-Ser
show the reaction diagram
-
best substrate
-
?
N-formyl-Met-Leu-Glu + H2O
formate + Met-Leu-Glu
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-NH2 + H2O
formate + Met-Leu-NH2
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
best substrate
-
?
N-formyl-Met-Leu-p-nitroanilide + H2O
formate + Met-Leu-p-nitroanilide
show the reaction diagram
-
best substrate
-
?
N-formyl-Met-Leu-Phe + H2O
formate + Met-Leu-Phe
show the reaction diagram
-
-
-
?
N-formyl-Met-Leu-Phe + H2O
formate + Met-Leu-Phe
show the reaction diagram
-
-
-
?
N-formyl-Met-Ser-Asn-Glu + H2O
formate + Met-Ser-Asn-Glu
show the reaction diagram
-
-
-
-
N-formyl-Met-Ser-Asn-Glu + H2O
formate + Met-Ser-Asn-Glu
show the reaction diagram
-
-
-
?
N-formyl-Met-Ser-Asn-Glu + H2O
formate + Met-Ser-Asn-Glu
show the reaction diagram
-
decreasing activity for tetrapeptides
-
?
N-formyl-Met-Val-Ser + H2O
formate + Met-Val-Ser
show the reaction diagram
Staphylococcus aureus, Staphylococcus aureus Mu50
-
-
-
?
N-formyl-Met-Xaa-Xbb-Tyr + H2O
formate + Met-Xaa-Xbb-Tyr
show the reaction diagram
-
consesus sequence for best substrates, Xaa: any amino acid except for Asp and Glu, Xbb: Lys, Arg, Tyr or Phe
-
?
N-formyl-Nle-Ala(NH2) + H2O
formate + Nle-Ala(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Ala(NH2) + H2O
formate + Nle-Ala(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Ala(NH2) + H2O
formate + Nle-Ala(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Ala-Ser + H2O
formate + Nle-Ala-Ser
show the reaction diagram
-
-
-
-
N-formyl-Nle-Ala-Ser + H2O
formate + Nle-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Nle-Arg(NH2) + H2O
formate + Nle-Arg(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Arg(NH2) + H2O
formate + Nle-Arg(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Arg(NH2) + H2O
formate + Nle-Arg(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Asn(NH2) + H2O
formate + Nle-Asn(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Asp(NH2) + H2O
formate + Nle-Asp(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Asp(NH2) + H2O
formate + Nle-Asp(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Asp(NH2) + H2O
formate + Nle-Asp(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Gln(NH2) + H2O
formate + Nle-Gln(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Glu(NH2) + H2O
formate + Nle-Glu(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Gly(NH2) + H2O
formate + Nle-Gly(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Gly(NH2) + H2O
formate + Nle-Gly(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Gly(NH2) + H2O
formate + Nle-Gly(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-His(NH2) + H2O
formate + Nle-His(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Leu(NH2) + H2O
formate + Nle-Leu(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Leu(NH2) + H2O
formate + Nle-Leu(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Leu(NH2) + H2O
formate + Nle-Leu(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Lys(NH2) + H2O
formate + Nle-Lys(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Met(NH2) + H2O
formate + Nle-Met(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-NH(CH3) + H2O
formate + Nle-NH(CH3)
show the reaction diagram
-
-
-
?
N-formyl-Nle-NH2 + H2O
formate + Nle-Nle-NH2
show the reaction diagram
-
-
-
?
N-formyl-Nle-Nle(NH2) + H2O
formate + Nle-Nle(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Phe(NH2) + H2O
formate + Nle-Phe(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Pro(NH2) + H2O
formate + Nle-Pro(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Ser(NH2) + H2O
formate + Nle-Ser(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Ser(NH2) + H2O
formate + Nle-Ser(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Ser(NH2) + H2O
formate + Nle-Ser(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Thr(NH2) + H2O
formate + Nle-Thr(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Trp(NH2) + H2O
formate + Nle-Trp(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Tyr(NH2) + H2O
formate + Nle-Tyr(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nle-Val(NH2) + H2O
formate + Nle-Val(NH2)
show the reaction diagram
-
-
-
?
N-formyl-Nva-Ala-Ser + H2O
formate + Nva-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Phe-Ala-Ser + H2O
formate + Phe-Ala-Ser
show the reaction diagram
-
-
-
?
N-formyl-Phe-Tyr-Phe + H2O
formate + Phe-Tyr-Phe
show the reaction diagram
-
only N-terminal Phe can replace Met
-
?
N-formyl-Phe-Tyr-Phe-His-beta-Ala-Arg + H2O
formate + Phe-Tyr-Phe-His-beta-Ala-Arg
show the reaction diagram
-
-
-
?
N-formyl-Phe-Tyr-Tyr + H2O
formate + Phe-Tyr-Tyr
show the reaction diagram
-
only N-terminal Phe can replace Met
-
?
N-formyl-phenylalanine nitrile + H2O
(S)-phenylalanine nitrile + formate
show the reaction diagram
-
-
98.8% (S)-enantiomer
?
N-formyl-phenylglycine + H2O
(S)-phenylglycine + formate
show the reaction diagram
-
-
99.6% (S)-enantiomer
?
N-formyl-phenylglycine amide + H2O
(S)-phenylglycine amide + formate
show the reaction diagram
-
-
99.7% (S)-enantiomer
?
N-formyl-phenylglycinol + H2O
(S)-phenylglycinol + formate
show the reaction diagram
-
-
90.5-93.3% (S)-enantiomer, depending on method
?
N-formyl-tert-leucine amide + H2O
(S)-tert-leucine amide + formate
show the reaction diagram
-
-
100% (S)-enantiomer
?
N-formyl-thiaphenyl-Ala-Leu-p-nitroanilide + H2O
formate + thiophenol + NH3 + Ala-Leu-p-nitroanilide
show the reaction diagram
-
excellent substrate
-
?
N-formyl-valine nitrile + H2O
(S)-valine nitrile + formate
show the reaction diagram
-
-
98.8% (S)-enantiomer
?
N-formylmethionine-alanine + H2O
formate + methionyl-alanine
show the reaction diagram
-
-
-
?
N-formylmethionine-alanine + H2O
formate + methionyl-alanine
show the reaction diagram
-
-
-
?
formyl-MVHQ + H2O
formate + MVHQ
show the reaction diagram
-
-
-
?
additional information
?
-
-
overview
-
-
-
additional information
?
-
-
proposed reaction cycle of peptide deformylase
-
-
-
additional information
?
-
-
no activity with formyl-Met-Thr-Pro-Met-Arg-Lys
-
-
-
additional information
?
-
-
no detectable activity with formyl-Met-Leu-Phe and formyl-Met-Leu-Pro
-
-
-
additional information
?
-
-
TbPDF1 is essential for normal growth. TbPDF1 is required for oxidative but not for mitochondrial substrate-level phosphorylation, TbPDF2 does neither affect growth on standard medium nor oxidative phosphorylation. A reduced level of TbPDF2 slows down growth in a medium that selects for highly efficient oxidative phosphorylation
-
-
-
additional information
?
-
-
catalyzes the deformylation of nascent peptides in bacteria
-
-
-
additional information
?
-
-
catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized polypeptides
-
-
-
additional information
?
-
catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized proteins
-
-
-
additional information
?
-
-
peptide deformylase is involved in the deformylation of the N-formyl group of newly synthesized polypeptides during protein synthesis
-
-
-
additional information
?
-
Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus enteridis, Staphylococcus non-hemolyticus
-
peptide deformylase is responsible for the removal of the N-formyl group from the terminal methionine residue in bacterial protein synthesis
-
-
-
additional information
?
-
the formyl group is removed from nascent proteins by peptide deformylase
-
-
-
additional information
?
-
-
the formyl moiety of newly synthesized peptides is removed by peptide deformylase
-
-
-
additional information
?
-
-
the removal of the formyl group from formylated methionine residues is facilitated by the action of peptide deformylase
-
-
-
additional information
?
-
-
HsPDF can process, in vitro, N-Met-formylated peptides
-
-
-
additional information
?
-
isoform PDF-2 exhibits no peptide deformylase activity
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
formyl-L-methionyl peptide + H2O
formate + L-methionyl peptide
show the reaction diagram
Q672W7
-
-
?
formyl-L-methionyl peptide + H2O
formate + L-methionyl peptide
show the reaction diagram
-
peptide deformylase catalyzes the removal of N-terminal formyl groups from nascent ribosome-synthesized polypeptides
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
Q9HBH1
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine polypeptide + H2O
formate + methionine-polypeptide
show the reaction diagram
P68826
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
Q9I7A8
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
Q5HPX6, Q5HQ78
-
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
requires at least a dipeptide as substrate, increasing activity with increasing peptide length until it reaches the tetrapeptide
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
deformylation required for methionine aminopeptidase activity in eubacteria, highly specific
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
deformylase is likely to play an essential role in the chloroplast
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
the enzyme is involved in maturation of proteins by cleaving the N-formyl group from N-blocked methionine polypeptides
-
-
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
essential role in protein processing in plastids
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
the enzyme is requiredfor the removal of the formyl group at the N-terminus of nascent polypeptide chains
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
posttranslational deformylation of N-formyl-Met-polypeptide
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
P68826
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
P68826
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
O31410
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
Q9I7A8
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
Q9F2F0
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
-
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
N-formyl-L-methionine-polypeptide + H2O
formate + L-methionine-polypeptide
show the reaction diagram
P96113
involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides
-
?
formyl-L-methionyl peptide + H2O
formate + methionyl peptide
show the reaction diagram
-
-
-
?
additional information
?
-
-
TbPDF1 is essential for normal growth. TbPDF1 is required for oxidative but not for mitochondrial substrate-level phosphorylation, TbPDF2 does neither affect growth on standard medium nor oxidative phosphorylation. A reduced level of TbPDF2 slows down growth in a medium that selects for highly efficient oxidative phosphorylation
-
-
-
additional information
?
-
-
catalyzes the deformylation of nascent peptides in bacteria
-
-
-
additional information
?
-
-
catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized polypeptides
-
-
-
additional information
?
-
P9WIJ3
catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized proteins
-
-
-
additional information
?
-
-
peptide deformylase is involved in the deformylation of the N-formyl group of newly synthesized polypeptides during protein synthesis
-
-
-
additional information
?
-
Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, Staphylococcus enteridis, Staphylococcus non-hemolyticus
-
peptide deformylase is responsible for the removal of the N-formyl group from the terminal methionine residue in bacterial protein synthesis
-
-
-
additional information
?
-
B6RGY0, Q5VNN5
the formyl group is removed from nascent proteins by peptide deformylase
-
-
-
additional information
?
-
-
the formyl moiety of newly synthesized peptides is removed by peptide deformylase
-
-
-
additional information
?
-
-
the removal of the formyl group from formylated methionine residues is facilitated by the action of peptide deformylase
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
-
Co2+-bound enzyme, highly stable
Co2+
-
cobalt-substituted enzyme
Co2+
-
the Co2+-containing enzyme form is active
Co2+
the activity of Co2+-containing enzyme is higher than the activity of Zn2+-containing enzyme
Co2+
-
can replace Fe2+ without loss of activity, enhances stability
Co2+
-
can replace Fe2+ without loss of activity, enhances stability
Co2+
-
can replace Fe2+ without loss of activity, enhances stability
Co2+
-
can replace Fe2+ without loss of activity, enhances stability
Co2+
can replace Fe2+ without loss of activity, enhances stability
Co2+
can replace Fe2+ without loss of activity, enhances stability
Co2+
-
-
Co2+
-
enzymatic activity of Escherichia coli PDF is retained after replacement of the active-site Fe2+ ion with Co2+
Co2+
Co2+-substituted isoform PDF-1 exhibits much higher enzymatic activity than that of Ni2+ and Zn2+ substituted PDF-1
Co2+
-
Co2+ is an optimal metal for increasing the activity of purified thioredoxin-fused PDF
Cu2+
-
the enzyme is strongly activated by Cu2+ with 50% increase of activity at 0.05 mM
Fe
-
PDF1B is an iron enzyme
Fe
-
enzyme form 2 contains up to 1.0 iron atom per polypeptide - 0.77 Fe2+ and 0.2 Fe3+ per polypeptide. The iron is likely coordinated by His132, His136 and Cys90 in the protein
Fe
-
enzyme contains iron
Fe2+
-
sensitive to reactive oxygen
Fe2+
-
natural metal, bound to active site; sensitive to reactive oxygen
Fe2+
-
enzyme contains Fe2+
Fe2+
-
required, irreversible oxidation to Fe3+ results in almost complete loss of activity
Fe2+
required, irreversible oxidation to Fe3+ results in almost complete loss of activity
Fe2+
required, irreversible oxidation to Fe3+ results in almost complete loss of activity
Fe2+
required, irreversible oxidation to Fe3+ results in almost complete loss of activity
Fe2+
-
Ni2+ or Co2+ leads to the retention of almost full catalytic activity
Fe2+
-
-
Fe2+
-
theoretically investigation of catalytic mechanism and metal specificity by studying both Fe2+-PDF and Zn2+-PDF. In both forms of PDF, the conserved Glu133 residue is protonated in the reactant complex, and acts as a general acid during the reaction. The initial reaction step is the nucleophilic attack of the metal-bound hydroxide on the carbonyl carbon of the substrate. Calculations indicate that the metal ion in Fe2+-PDF is always pentacoordinated during the reaction process, while that in Zn2+-PDF is only tetrahedrally coordinated and not bound to the substrate in the reactant complex. This difference in their metal coordination is suggested to account for the lower activity of Zn2+-PDF in comparison with Fe2+-PDF
Fe2+
-
pysiological metal ion
Fe2+
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
Fe2+
-
the native metal in Escherichia coli PDF is iron
Fe2+
-
the native enzyme contains iron
Fe2+
-
only Fe2+ and Co2+ ions are capable of supporting the enzyme activity of PDF
Fe2+
-
the imidazole ring of histidine can combine with a metal ion such as iron. The activity of the iron form of the enzyme is higher than the nickel form
Fe3+
-
more stable activity than with Fe2+
Iron
-
iron-containing enzyme
Ni2+
-
450fold increasing activity, stabilizes active state
Ni2+
-
gives insensitivity to oxidation
Ni2+
-
enzyme nearly retains its activity on substitution of the naturally occuring Fe2+ by Ni2+
Ni2+
-
can replace Fe2+ without loss of activity, enhances stability
Ni2+
-
can replace Fe2+ without loss of activity, enhances stability
Ni2+
-
can replace Fe2+ without loss of activity, enhances stability
Ni2+
-
can replace Zn2+
Ni2+
-
can replace Fe2+ without loss of activity, enhances stability
Ni2+
can replace Fe2+ without loss of activity, enhances stability
Ni2+
can replace Fe2+ without loss of activity, enhances stability
Ni2+
-
PdfA with Zn2+ substituted is much less active than the Ni2+ forms of the enzyme; PdfB with Zn2+ substituted is much less active than the Ni2+ forms of the enzyme; PdfC with Zn2+ substituted is as active as the Ni+ form for the fMA substrate and exhibits substrate specificity different from that of Ni2+ PdfC
Ni2+
-
enzyme resident cofactor
Ni2+
-
enzymatic activity of Escherichia coli PDF is retained after replacement of the active-site Fe2+ ion with Ni2+, the activity of the protein is not affected by Ni2+ concentrations up to 0.1 mM
Ni2+
isoform PDF-1 shows much weaker binding ability towards Ni2+ than towards Co2+ and Zn2+
Ni2+
-
the imidazole ring of histidine can combine with a metal ion such as nickel. The activity of the iron form of the enzyme is higher than the nickel form
Zinc
-
ratio of results of zinc to protein is 1:1
Zn
-
PDF1A is a zinc enzyme, contains 0.8 mol of Zn per mol of enzyme
Zn2+
-
10fold more active than Co2+-prepared enzyme
Zn2+
-
Zn2+-bound enzyme inactive in crystallization analysis
Zn2+
-
cruical for activity
Zn2+
-
Zn2+-bound form not sensitive to oxidation
Zn2+
-
enzyme form 1 contains approximately 1.0 Zn2+ per polypeptide chain, the zinc-containing protein 1 is likely formed during iron depletion caused by overexpression
Zn2+
-
zinc metalloprotease
Zn2+
-
His132 and His136 bind Zn2+ through their Nepsilon1 imidazole nitrogens; location of the active site around the zinc ion; zinc metalloprotease
Zn2+
the activity of Co2+-containing enzyme is higher than the activity of Zn2+-containing enzyme
Zn2+
-
required
Zn2+
-
it contains 1.1 Zn2+ ion/polypeptide
Zn2+
-
PdfA with Zn2+ substituted is much less active than the Ni2+ forms of the enzyme; PdfB with Zn2+ substituted is much less active than the Ni2+ forms of the enzyme; PdfC with Zn2+ substituted is as active as the Ni+ form for the fMA substrate and exhibits substrate specificity different from that of Ni2+ PdfC
Zn2+
-
theoretically investigation of catalytic mechanism and metal specificity by studying both Fe2+-PDF and Zn2+-PDF. In both forms of PDF, the conserved Glu133 residue is protonated in the reactant complex, and acts as a general acid during the reaction. The initial reaction step is the nucleophilic attack of the metal-bound hydroxide on the carbonyl carbon of the substrate. Calculations indicate that the metal ion in Fe2+-PDF is always pentacoordinated during the reaction process, while that in Zn2+-PDF is only tetrahedrally coordinated and not bound to the substrate in the reactant complex. This difference in their metal coordination is suggested to account for the lower activity of Zn2+-PDF in comparison with Fe2+-PDF
Zn2+
-
the Zn2+-PDF complex shows 500fold decreased activity
Zn2+
compared with Co2+-substituted PDF-1, the enzymatic activity of Zn2+-substituted PDF-1 shows a 4fold decrease, PDF-1 binds more Zn2+ (1.36 mol Zn per mol protein) than Co2+ (0.87 mol Co per mol protein), though the activity of Zn-PDF is much lower
Zn2+
contains zinc in the binding site
Mn2+
-
250fold increase of activity
additional information
-
Ni2+ and Zn2+-containing enzyme forms are inactive
additional information
-
theoretical study of the catalytic mechanism and metal-ion dependence of peptide deformylase
additional information
Co2+-, Zn2+-, or Ni2+-substituted isoform PDF-2 exhibits no enzymatic activity
additional information
-
Zn2+ and Ni2+ are not capable of supporting the enzyme activity of PDF
additional information
-
Co2+, Mg2+, Mn2+ do not significantly affect the enzyme activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(1-hydroxyaminomethyl-2-phenylethyl)carbamic acid tert-butyl ester
; AtPDF2
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
AtPDF2
(2E)-3-(2,5-dihydroxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one
-
(2R)-N-[(1S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
-
-
(2R)-N-[(1S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
-
Zn-BbPDF1-HT
(2R)-N-[(1S)-5-amino-1-(hexylcarbamoyl)pentyl]-2-[[formyl(hydroxy)amino]methyl]heptanamide
-
-
(2R)-N-[(3S)-2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4,4-dimethylpent-1-en-3-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
-
-
(2R)-N4-hydroxy-N1-[(2R)-1-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(5-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(pyridin-2-yl)-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-phenyl-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[(1R)-1-phenylethyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[(1S)-1-phenylethyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pent-4-ynoic acid
-
(2S)-N-(2-bromophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(2-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(3-bromophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(4-bromophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(5-fluoro-1-oxidopyridin-2-yl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-(5-fluoropyridin-2-yl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-N-cyclopropyl-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S,3R,4S,5R,6R)-2-[(5-bromo-1H-indol-3-yl)oxy]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
-
(2S,3R,4S,5S,6R)-2-[(5-bromo-6-chloro-1H-indol-3-yl)oxy]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
-
(3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide
-
(3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid
-
(3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide
-
(3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid
-
(E)-N-phenethyl-3-(3,4-diacetoxyphenyl)acrylamide
IC50: 0.00125 mM
(R)-2-[(formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-5-amino-1-phenylcarbamoyl-pentyl)-amide
-
-
(R)-2-[(formyl-hydroxy-amino)-methyl]-hexanoic acid [(S)-5-amino-1-((R)-2-isopropoxymethyl-pyrrolidine-1-carbonyl)-pentyl]-amide
-
-
(R)-2-[(formyl-hydroxy-amino)-methyl]-hexanoic acid [(S)-5-amino-1-((S)-2-isopropoxymethyl-pyrrolidine-1-carbonyl)-pentyl]-amide
-
-
(RS)- and (SR)-3-[(RS)-benzenesulfinyl]heptanoic acid hydroxyamide
-
mixture of both components, IC50: 0.0001 mM, possible antimicrobial agent
(RS)-3-(phenylsulfonyl)heptanoic acid hydroxyamide
-
IC50: 0.035 micro molar, possible antimicrobial agent
(S)-2-O-(H-phosphonoxy)-L-caproyl-L-Leu-p-nitroanilide
-
similar inhibition of Fe2+- and Co2+-bound enzyme
-
(S)-2-O-(phosphonoxy)-L-caproyl-L-leucyl-p-nitroanilide
-
-
1,10-phenanthroline
-
similar inhibition of Fe2+- and Co2+-bound enzyme
1,10-phenanthroline
-
-
1,10-phenanthroline
-
competitive
1,10-phenanthroline
-
complete inhibition at 5 mM
1,10-phenanthroline
-
competitive with respect to N-formyl-Met-Val; time-dependent inhibition of cobalt-substituted enzyme with loss of the active site metal
1,10-phenanthroline
-
competitive with respect to N-formyl-Met-Val
1,10-phenanthroline
-
-
1,2-Ethanedithiol
-
irreversible
1,3-propanedithiol
-
irreversible
1,5-pentanedithiol
-
-
1-(2-[[formyl(hydroxy)amino]methyl]hexanoyl)-4-methylidene-N,N-dimorpholin-4-yl-L-prolinamide
-
-
-
1-(3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl)-4-methylidene-N,N-dimorpholin-4-yl-L-prolinamide
-
-
-
1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one
AtPDF2
1-(5-bromo-2-methyl-1H-indol-3-yl)-N-hydroxymethanamine
-
-
1-(5-bromo-2-methyl-1H-indol-3-yl)-N-hydroxymethanamine
-
1-(5-bromo-2-methyl-1H-indol-3-yl)-N-hydroxymethanamine
-
-
1-(methylamino)-3-[2-(prop-2-en-1-yl)phenoxy]propan-2-ol
-
1-[(2-methoxyphenyl)carbamoyl]prolyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(2-methylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(3-methylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methoxyphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-morpholin-4-ylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-piperidin-1-ylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-pyrrolidin-1-ylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-oxidomorpholin-4-yl)phenyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2,2-dimethylpropanoyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2,2-dimethylpropanoyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2-methylpropanoyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2-methylpropanoyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(3-methylbutanoyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(3-methylbutanoyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(cyclopropylcarbonyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(cyclopropylcarbonyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethoxycarbonyl)-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethylcarbamoyl)-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxyacetyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxyacetyl)-L-prolinamide
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxycarbonyl)-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methylcarbamoyl)-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(prop-2-en-1-ylcarbamoyl)-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(2-hydroxyethyl)carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-hydroxypropyl)carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-phenylpropyl)carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(cyclopentyloxy)carbonyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(propan-2-yloxy)carbonyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(tetrahydro-2H-pyran-4-yloxy)carbonyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(1H-imidazol-4-yl)ethyl]carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyrazin-2-yl)ethyl]carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-2-yl)ethyl]carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-3-yl)ethyl]carbamoyl]-L-prolinamide
-
-
-
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-4-yl)ethyl]carbamoyl]-L-prolinamide
-
-
-
1-[5-bromo-2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]-N-hydroxymethanamine
-
-
1-[5-bromo-2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]-N-hydroxymethanamine
-
1-[5-bromo-2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]-N-hydroxymethanamine
-
-
2',2'-bisepigallocatechin monogallate
-
-
2,3-dimercapto-1-propanesulfonic acid
-
-
2,3-dimercapto-1-propanol
-
-
2-(1-benzyl-5-chloro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.002 mM
2-(1-butyl-5-chloro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.00059 mM
2-(2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.00076 mM
2-(4-benzyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-oxoacetamide
-
-
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
; AtPDF2
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(4-[2-[(2,5-difluorophenyl)amino]-2-oxoethyl]-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-oxoacetamide
-
-
2-(5-bromo-1-cyclopropyl-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.000069 mM
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.0031 mg/ml
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.006 mg/ml
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-bromo-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.000098 mM
2-(5-bromo-2-methyl-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-bromo-2-methyl-1H-indol-3-yl)-N-hydroxyacetamide
-
2-(5-bromo-2-methyl-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
AtPDF2
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
-
2-(5-bromo-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)-N-hydroxyacetamide
-
IC50: 0.000049 mM
2-(5-chloro-1-cyclopropyl-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.00011 mM
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.013 mg/ml
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.025 mg/ml
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-chloro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
inhibitor shows good selectivity for peptide deformylase over several endoproteases including matrix metalloproteases, however it shows only weak antibacterial activity. IC50: 0.00012 mM
2-(5-chloro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)-N-hydroxyacetamide
-
inhibitor shows good selectivity for peptide deformylase over several endoproteases including matrix metalloproteases, however it shows only weak antibacterial activity. IC50: 0.00031 mM
2-(5-chloro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide
-
IC50: 0.027 mM
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.027 mg/ml
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.04 mg/ml
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(5-fluoro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
-
IC50: 0.00087 mM
2-(5-fluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)-N-hydroxyacetamide
-
IC50: 0.00087 mM
2-(5-methoxy-1H-indol-3-yl)-N-hydroxyacetamide
; AtPDF2
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
2-(biphenyl-4-yl)-N-oxoacetamide
-
-
2-(indol-3-yl)-N-hydroxyacetamide
; AtPDF2
2-(indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.16 mg/ml
2-(indol-3-yl)-N-hydroxyacetamide
-
MIC is 0.115 mg/ml
2-amino-5-mercapto-1,3,4-thiadiazole
-
slow-binding inhibitor of PDF when dissolved only in dimethylformamide, but not in any other solvent, and aged (via the formation of a disulfide bond) to a dimeric form
2-amino-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylacetamide
-
2-butyl-5,7-dimethyl-3-[2''-(1H-tetrazol-5-ylmethyl)-[1,1',4',1'']terphenyl-4-yl]-3H-imidazo[4,5-b]pyridine
-
belongs to a class of angiotensin II receptor antagonists, potent inhibitor, IC50: 0.0076 mM
2-mercaptoethanol
-
30% inhibition at 1 mM
2-oxo-pyrrolidine with chelators
-
-
-
2-thioxo-4-thiazolidinone N-hexanoic acid
-
IC50 against Escherichia coli peptide deformylase: 0.00166 mM
2-thioxo-4-thiazolidinones
-
-
-
2-[(12R,17aS)-1,13-dioxohexadecahydro-1H-pyrrolo[1,2-a][1,4]diazacyclopentadecin-12-yl]-N-hydroxyacetamide
-
-
2-[(3-aminopropanoyl)amino]-3-phenylpropanoic acid
-
2-[(3S,6R)-3-tert-butyl-2,5-dioxo-1,4-diazacyclopentadecan-6-yl]-N-hydroxyacetamide
-
-
2-[2,2-dioxido-5-(trifluoromethyl)-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-hydroxyacetamide
-
IC50: 0.00013 mM
2-[2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl]-1-phenylethanone
-
2-[4-(3,3-dimethyl-2-oxobutyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-oxoacetamide
-
-
2-[4-(3-methylbutyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-oxoacetamide
-
-
2-[4-(cyclobutylmethyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-oxoacetamide
-
-
2-[5-chloro-2,2-dioxido-1-(3-phenylpropyl)-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-hydroxyacetamide
-
IC50: 0.00029 mM
3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester
AtPDF2
3-carboxymethylindol-1-carboxylic acid benzyl ester
; AtPDF2
3-methoxycatechol
-
-
3-methyl-N-(1,3-thiazol-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(2-methylpropanoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(morpholin-4-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(phenylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(piperidin-1-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(pyridin-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(pyridin-3-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(pyridin-4-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-(thiophen-2-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-methyl-N-[methyl(phenyl)carbamoyl]-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
3-[5'-benzyl-2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
-
potent inhibitor, IC50: 0.0342 mM, the acidic moiety forms direct ionic interactions with active site metal cation
5'-phosphothiorate modified antisense oligodeoxyribonucleotides
-
-
-
5-(1,1-dimethyl-propyl)-4'-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl)-biphenyl-2-sulfonylcarbamate
-
competitive inhibition, IC50: 0.015 mM, the acidic moiety forms direct ionic interactions with active site metal cation
-
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
AtPDF2
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
-
MIC is 0.016 mg/ml
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
-
MIC is 0.12 mg/ml
5-chloro-2-propyl-3-[2''-(1H-tetrazol-5-ylmethyl)-[1,1',4',1'']terphenyl-4-yl]-3H-imidazo[4,5-b]pyridine
-
belongs to a broad class of angiotensin II receptor antagonists, potent competitive inhibitor, IC50: 0.0039 mM, the acidic moiety forms direct ionic interactions with active site metal cation
5-[[(2-chlorophenyl)sulfanyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
-
-
5-[[(3,4-dichlorophenyl)sulfanyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
-
-
5-[[(3-chlorophenyl)sulfonyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
-
-
5-[[(4-chlorophenyl)sulfanyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
-
-
5-[[(4-methoxyphenyl)sulfonyl]methyl]-1,2-oxazole-3-carbohydrazide
-
-
7,8-dihydroxyflavone
-
-
8-hydroxyquinoline
-
50% inhibition at 2 mM
actinonin
-
pseudo-peptide hydroxamate, potent inhibitor Kd: 0.3 nM
actinonin
-
peptide deformylase 1 and 2
actinonin
-
50% inhibition of enzyme Def at 95 nM, 50% inhibition of enzyme form YkrB by 130 nM
actinonin
-
competitive, IC50: 43 nM
actinonin
-
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM
actinonin
-
IC50: 0.000043 mM
actinonin
-
-
actinonin
-
MIC is 0.0013 mg/ml
actinonin
-
MIC is 0.034 mg/ml
actinonin
-
i.e. 3-[(1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl)carbamoyl]octanohydroxamic acid, a naturally occurring potent PDF inhibitor
actinonin
a naturally occurring PDF inhibitor
actinonin
-
efficient inhibitor
actinonin
-
complete inhibition at 0.005 mM
actinonin
-
actinonin does exert a significant inhibitory effect on enzyme activity in the presence of 0.25 mM substrate (complete inhibition at 10 nM)
actinonin
-
slow, tight-binding inhibitor
actinonin
-
over 80% inhibition of the recombinant enzymatic activity is observed at 10 nM actinonin
aldehyde peptide
-
IC50 against Escherichia coli peptide deformylase: 0.01 mM
-
alkyl-succinate-proline hydroxamate
-
IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM
analogues of actinonin
-
35 different compounds were synthesized and compared to the inhibitory activity of actinonin
-
BB-83698
Staphylococcus enteridis, Staphylococcus non-hemolyticus
-
-
BB-83698
-
-
BB83698
-
-
benzimidazole N-formyl hydroxylamine
-
-
benzothiazinone derivatives
-
IC50: 0.000005 mM
-
benzothiazolylidene hydroxamic acid derivatives
-
IC50 against Escherichia coli peptide deformylase: 0.00104 mM
-
benzyl 5-bromo-3-[2-(hydroxyamino)-2-oxoethyl]-1H-indole-1-carboxylate
-
-
benzyl 5-bromo-3-[2-(hydroxyamino)-2-oxoethyl]-1H-indole-1-carboxylate
-
benzyl 5-bromo-3-[2-(hydroxyamino)-2-oxoethyl]-1H-indole-1-carboxylate
-
-
beta-sulfonylhydroxamic acid
-
IC50 against Escherichia coli peptide deformylase: 0.000016 mM
carbamate N-formyl hydroxylamine
-
-
chloranil
-
-
Co(III)1
-
peptide cleaving catalyst
diprop-2-en-1-yl (2S)-2-aminobutanedioate
-
EDTA
-
convertion to the apoenzyme during 1 h at 10 mM
EDTA
-
slight inhibition at 10 mM
epigallocatechin 3,5-digallate
-
-
epitheaflavin monogallate
-
-
ethyl 2-amino-3-(benzylsulfanyl)propanoate
-
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
-
Fe3+
-
inactivation due to oxidation of Fe2+ to Fe3+
formylmethionine
-
-
glutathione
-
10% inhibition at 1 mM
hematein
-
-
hematoxylin
-
-
heteroarylaryl(P2'/P3')N-formyl hydroxylamine
-
-
hydantoin
-
IC50 against Escherichia coli peptide deformylase: 0.0002 mM
hydrazide N-formyl hydroxylamine
-
-
imino[(5-methoxy-5-oxo-4-[2-(sulfanylmethyl)hexanoyl]aminopentyl)amino]methaneamine
-
-
imino[(5-methoxy-5-oxo-4-[2-(sulfanylmethyl)hexanoyl]aminopentyl)amino]methaneamine
-
-
irigenol
-
-
isoxazole-3-hydroxamic acid derivatives
-
IC50 against Escherichia coli peptide deformylase: 0.0034 mM
-
isoxazole-3-hydroxamic acids
-
23 different compounds were synthesized and compared to the inhibitory activity of actinonin
-
LBM-415
Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus
-
-
LBM-415
-
-
methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate
-
methyl-1-(sulfanylmethyl)hexanoate
-
-
methyl-1-(sulfanylmethyl)hexanoate
-
-
N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine
AtPDF2
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
AtPDF2
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
MIC is 0.035 mg/ml
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
MIC is 0.065 mg/ml
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
-
N-(2-methoxybenzoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-(2-[[(2S)-2-[[1,3-bis(4-fluorophenyl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]carbonyl]hexyl)-N-hydroxyformamide
-
-
-
N-(2-[[(2S)-2-[[1,3-bis(4-hydroxyphenyl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]carbonyl]hexyl)-N-hydroxyformamide
-
-
-
N-(2-[[(2S)-2-[[1,3-bis(5-fluoro-1-oxidopyridin-2-yl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]carbonyl]hexyl)-N-hydroxyformamide
-
-
-
N-(2-[[(2S)-2-[[1,3-bis(5-fluoropyridin-2-yl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]carbonyl]hexyl)-N-hydroxyformamide
-
-
-
N-(2-[[(2S)-2-[[1,3-bis(5-methyl-1,3-thiazol-2-yl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]carbonyl]hexyl)-N-hydroxyformamide
-
-
-
N-(3,4-difluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-chloro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-chloro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-chloro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-fluoro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-fluoro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-fluoro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloheptadec-6-yl)-methyl-N-hydroxy-formamide
-
-
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclohexadec-6-yl)-methyl-N-hydroxy-formamide
-
-
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloicos-6-yl)-methyl-N-hydroxy-formamide
-
-
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl)-methyl-N-hydroxy-formamide
-
-
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclotridec-6-yl)-methyl-N-hydroxy-formamide
-
-
N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-(5-fluoro-1-oxidopyridin-2-yl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
-
-
-
N-(benzylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-(benzyloxy)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
-
-
N-(cyclobutylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-(cyclobutylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-(cyclobutylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-(cyclohexylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-(cyclohexylcarbamoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-(cyclohexylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-(cyclohexylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-(cyclopentylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-(cyclopentylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-(cyclopentylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide
-
-
N-(tert-butoxycarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-(tert-butylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-acetyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-acetyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-alkyl urea hydroxamate
-
IC50 against Escherichia coli peptide deformylase: 0.000003 mM
N-benzoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-benzoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
N-benzoyl-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-benzyloxycarbonyl-Leu-norleucinal
-
most potent competitive inhibitor
-
N-carbamoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-formyl-L-methionylalanine
-
inhibition above 4 mM
N-formyl-Met-Ala-Ser
-
the enzyme activity of truncated PDF-1DeltaN37 is inhibited by an excess of N-formyl-Met-Ala-Ser substrate
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
-
i.e. SB 543668, IC50: 0.00115 mM
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
-
i.e. SB 543668, IC50: 0.00032 mM
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
-
i.e. SB 543668, IC50: 0.0022 mM
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
-
i.e. SB 543668, IC50: 0.0039 mM
N-formyl-N-hydroxy-3-phenylpropylamine
-
i.e. SB 485345, IC50: 0.00016 mM
N-formyl-N-hydroxy-3-phenylpropylamine
-
i.e. SB 485345, IC50: 0.00015 mM
N-formyl-N-hydroxy-3-phenylpropylamine
-
i.e. SB 485345, IC50: 0.00025 mM
N-formyl-N-hydroxy-3-phenylpropylamine
-
i.e. SB 485345, IC50: 0.0004 mM
N-hydroxy urea
-
IC50 against Escherichia coli peptide deformylase: 0.0022 mM
N-hydroxy-2-(1H-indol-3-yl)acetamide
-
-
N-hydroxy-2-(1H-indol-3-yl)acetamide
-
N-hydroxy-2-(1H-indol-3-yl)acetamide
-
-
N-hydroxy-2-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide
-
IC50: 0.0029 mM
N-hydroxy-2-(5-methoxy-1H-indol-3-yl)acetamide
-
-
N-hydroxy-2-(5-methoxy-1H-indol-3-yl)acetamide
-
N-hydroxy-2-(5-methoxy-1H-indol-3-yl)acetamide
-
-
N-hydroxy-2-(substituted phenyl) acetamide
-
-
N-hydroxy-2-[2-oxo-5-(trifluoromethyl)-1,4-dihydroquinazolin-3(2H)-yl]acetamide
-
IC50: 0.00023 mM
N-hydroxy-5-([[2-(propan-2-yl)phenyl]sulfanyl]methyl)-1,2-oxazole-3-carboxamide
-
-
N-hydroxy-5-([[4-(trifluoromethyl)phenyl]sulfanyl]methyl)-1,2-oxazole-3-carboxamide
-
-
N-hydroxy-N-(3-hydrazino-3-oxopropyl)formamide
-
-
N-hydroxy-N-[(2R)-2-[[(2S)-2-(morpholin-4-ylcarbonyl)-2,5-dihydro-1H-pyrrol-1-yl]carbonyl]hexyl]formamide
-
-
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
-
i.e. SB 505684, IC50: 0.0028 mM
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
-
i.e. SB 505684, IC50: 0.00104 mM
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
-
i.e. SB 505684, IC50: 0.00109 mM
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
-
i.e. SB 505684, IC50: 0.0022 mM
N-methoxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
-
-
N-methoxy-N-methyl-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
-
-
N-oxo-2-[3-oxo-4-(2-phenylethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
-
-
N-oxo-2-[3-oxo-4-(tetrahydro-2H-pyran-2-ylmethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
-
-
N-oxo-2-[3-oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
-
-
N-substituted methionine hydrazide
-
IC50 against Escherichia coli peptide deformylase: 0.2 mM
N-sulfonyl-L-Val-L-Leu-hydroxamate
-
-
N-trans-caffeoyltyramine
IC50: 0.0108 mM
N-[(2-aminoethyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-[(2-methoxyethyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N-hydroxy-N2-(3-methylbutyl)glycinamide
-
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(2-cyclopentylethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclobutylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopropylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]alanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]leucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]norleucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]phenylalanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2-methoxyphenyl)carbamoyl]valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
-
N-[(2R)-2-(cyclopentylmethyl)-3-(2-[5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methylpyrimidin-4-yl]hydrazinyl)-3-oxopropyl]-N-hydroxyformamide
-
-
-
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
-
-
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide
-
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide
-
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide
-
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide
-
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide
-
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide
-
N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
-
N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide
-
N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
-
N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide
-
N-[(3-amino-3-oxopropyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-[(cyclobutyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-[(cyclohexyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
-
-
-
N-[2-(5-bromo-2-methyl-1H-indole-3-yl)methyl]hydroxylamine
; AtPDF2
N-[2-(cyclopentylmethyl)-3-[(2S)-2-[(1,3-dicyclopropyltriazan-2-yl)carbonyl]-4-methylidenepyrrolidin-1-yl]-3-oxopropyl]-N-hydroxyformamide
-
-
-
N-[2-([(2S)-2-[(1,3-diphenyltriazan-2-yl)carbonyl]-4-methylidenepyrrolidin-1-yl]carbonyl)hexyl]-N-hydroxyformamide
-
-
-
N-[3-(4-acetamidobutyl)-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl]methyl-N-hydroxy-formamide
-
-
N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacycloicos-6-yl]methyl-N-hydroxyformamide
-
-
N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacyclopentadec-6-yl]methyl-N-hydroxyformamide
-
-
N-[3-chloro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[3-fluoro-4-(1-oxidopiperidin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[3-fluoro-4-(1H-pyrrol-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[3-fluoro-4-(4-methyl-1,4-diazepan-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[3-fluoro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[3-[(2S)-2-[[1,3-bis(4-fluorophenyl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
-
-
-
N-[3-[(2S)-2-[[1,3-bis(5-fluoro-1-oxidopyridin-2-yl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
-
-
-
N-[3-[(2S)-2-[[1,3-bis(5-fluoropyridin-2-yl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
-
-
-
N-[3-[(2S)-2-[[1,3-bis(5-methyl-1,3-thiazol-2-yl)triazan-2-yl]carbonyl]-4-methylidenepyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
-
-
-
N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[4-(4-ethylpiperazin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus, Streptococcus pneumoniae
-
-
N-[4-(trifluoromethyl)benzoyl]-L-Met
-
time-dependent inhibition of zinc and cobalt deformylase, inhibition of full-length Co-PDF is competitive
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide
-
time-dependent inhibition of zinc and cobalt deformylase
N-[[(3S,6R)-3-tert-butyl-2,5-dioxo-1,4-diazacyclopentadecan-6-yl]methyl]-N-hydroxyformamide
-
Zn-BbPDF1-HT
N-[[5-bromo-2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]methyl]-N-hydroxyformamide
-
-
N-[[5-bromo-2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]methyl]-N-hydroxyformamide
-
N-[[5-bromo-2-methyl-1-(phenylsulfonyl)-1H-indol-3-yl]methyl]-N-hydroxyformamide
-
-
N2-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-phenyl-L-lysinamide
-
-
naphthalen-1-yl[[3-(trifluoromethyl)benzyl]amino]acetic acid
-
-
Ni2+
-
addition of 1 mM Ni2+ increases the PDF activity by 70%, with 20 mM Ni2+, the activity decreases by 23% compared with the low Ni2+ concentration
Ni2+
-
less than 40% residual activity at 0.1 mM
p-chloromercuribenzoate
-
potent inhibitor, IC50: 0.07 mM
Peptide aldehydes
-
peptide aldehydes containing a methional or leucinal
Phe-Arg-beta-naphthylamide
-
-
piperidin-4-yl [1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolyl]carbamate
-
-
-
Polyethylene glycol
-
-
polylethylene glycol
-
competitive inhibitor with respect to formylmethionine
-
pseudopeptide metabolites
-
IC50 against Escherichia coli peptide deformylase: 0.000030 mM
-
Purpurogallin
-
-
pyrogallin
-
-
pyrrolidine bicyclic(P2'/P3')compounds
-
-
-
quinalizarin
-
-
quinazoline hydroxamic acid
-
IC50 against Escherichia coli peptide deformylase: 0.00012 mM
reverse hydroxamate
-
British Biotech BB-83698
reverse hydroxamates
-
-
-
siRNA HsPDF 581-601
-
transfection of HeLa cells
-
siRNA HsPDF 659-679
-
transfection of HeLa cells
-
SKI-AC-1
-
IC50: 0.000072 mM, actionin analog
SKI-AC-10
-
IC50: 0.000078 mM, actionin analog
SKI-AC-11101
-
IC50: 0.000076 mM, actionin analog
-
SKI-AC-111101
-
IC50: 0.0000600 mM, actionin analog
SKI-AC-111110
-
IC50: 0.000427 mM, actionin analog
-
SKI-AC-111111
-
IC50: 0.000069 mM, actionin analog
SKI-AC-111112
-
IC50: 0.000234 mM, actionin analog
-
SKI-AC-111113
-
IC50: 0.000177 mM, actionin analog
-
SKI-AC-111114
-
IC50: 0.000300 mM, actionin analog
-
SKI-AC-11112
-
IC50: 0.000365 mM, actionin analog
-
SKI-AC-11113
-
IC50: 0.000500 mM, actionin analog
-
SKI-AC-11114
-
IC50: 0.000276 mM, actionin analog
-
SKI-AC-11115
-
IC50: 0.000473 mM, actionin analog
-
SKI-AC-11116
-
IC50: 0.000335 mM, actionin analog
-
SKI-AC-11117
-
IC50: 0.000086 mM, actionin analog
SKI-AC-11118
-
IC50: 0.000115 mM, actionin analog
SKI-AC-11119
-
IC50: 0.000134 mM, actionin analog
-
SKI-AC-11128
-
IC50: 0.000522 mM, actionin analog
-
SKI-AC-11138
-
IC50: 0.000500 mM, actionin analog
-
SKI-AC-11148
-
IC50: 0.0000600 mM, actionin analog
-
SKI-AC-11158
-
IC50: 0.000500 mM, actionin analog
-
SKI-AC-11168
-
IC50: 0.000192 mM, actionin analog
-
SKI-AC-11178
-
IC50: 0.000200 mM, actionin analog
-
SKI-AC-11188
-
IC50: 0.000120 mM, actionin analog
-
SKI-AC-11198
-
IC50: 0.000090 mM, actionin analog
SKI-AC-3
-
IC50: 0.000500 mM, actionin analog
-
SKI-AC-5
-
IC50: 0.000400 mM, actionin analog
-
SKI-AC-51121
-
IC50: 0.000400 mM, actionin analog
-
SKI-AC-6
-
IC50: 0.000097 mM, actionin analog
SKI-AC-8
-
IC50: 0.000093 mM, actionin analog
SKI-AC-9
-
IC50: 0.000151 mM, actionin analog
-
SKI-AC-I-18
-
IC50: 0.000404 mM, actionin analog
-
SKI-AC-I-19
-
IC50: 0.000239 mM, actionin analog
-
tert-butyl 1-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]hexanoyl]-L-prolinate
-
-
theaflavin
-
-
theaflavin monogallate
-
-
thio peptide
-
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif
-
thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester
AtPDF2
thioacetic acid S-[3-(indol-3-yl)-2-oxopropyl] ester
; AtPDF2
thiol peptide
-
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified
-
Thiophenol
-
IC50: 0.5 mM
thiram
-
-
thyropropic acid derivatives
-
IC50 against Escherichia coli peptide deformylase: 0.001 mM
-
urea analogs(P2'/P3')of N-formyl hydroxylamine
-
-
Zn2+
-
converting enzyme to inactive state
Zn2+
-
tightly bound, very poor activity
additional information
-
the results of the study may provide the basis for the design of more potent and selective deformylase inhibitors as potential antibacterial agents
-
additional information
-
theoretical study of Escherichia coli peptide deformylase inhibition by several drugs
-
additional information
-
development of a high-throughput assay to screen for inhibitors
-
additional information
-
purified thioredoxin-fused PDF containing Fe2+ ion is inactivated during purification
-
additional information
-
not inhibited by actinonin
-
additional information
-
there is no significant inhibitory effect of actinonin on enzyme activity when the concentration of substrate is 4 mM
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1,10-phenanthroline
-
1-5 mM strongly activates deformylase activity, activity increases 6fold at 1 mM
EDTA
-
1-20 mM strongly activates deformylase activity, activity increases up to 70% at 10 mM
KCl
-
2fold increase within 0-0.5 M, beyond 0.5 M smaller extend of increase
N-formyl-Met-Ala-Ser
-
the activity increases with substrate concentration up to 35 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.027
formyl-L-Met-Leu-p-nitroanilide
-
-
8.14
formyl-MAHA
-
-
42.9
formyl-MEHQ
-
-
0.14
formyl-Met-Ala
-
Zn2+ PdfC
0.35
formyl-Met-Ala
-
Ni2+ PdC
1.5
formyl-Met-Ala
-
Ni2+ PdB
2.7
formyl-Met-Ala
-
Zn2+ PdfB
3.4
formyl-Met-Ala
-
mutant R79A
4.1
formyl-Met-Ala
-
wild-type
5
formyl-Met-Ala
-
mutant R79K
5.6
formyl-Met-Ala
-
mutant R78K
6.4
formyl-Met-Ala
-
mutant R78A
6.5
formyl-Met-Ala
-
mutant R77A
6.9
formyl-Met-Ala
-
mutant R77K
9.3
formyl-Met-Ala
-
mutant R77D
11.7
formyl-Met-Ala
-
mutant R78D
14
formyl-Met-Ala
-
Zn2+ PdfA
28
formyl-Met-Ala
-
Ni2+ PdA
1.7
formyl-Met-Ala-His-Ala
-
-
2.5
formyl-Met-Ala-His-Ala-Ala-Gln
-
-
0.34
formyl-Met-Ala-Lys-Tyr
-
Zn2+ PdB
1.3
formyl-Met-Ala-Lys-Tyr
-
Ni2+ PdB
1.4
formyl-Met-Ala-Lys-Tyr
-
Zn2+ PdfB
2.1
formyl-Met-Ala-Lys-Tyr
-
Ni2+ PdC
3.8
formyl-Met-Ala-Lys-Tyr
-
Zn2+ PdfC
6.1
formyl-Met-Ala-Lys-Tyr
-
Zn2+ PdfA
7.6
formyl-Met-Ala-Lys-Tyr
-
Ni2+ PdA
0.3
formyl-Met-Ala-Ser
-
Ni2+ PdB
1.7
formyl-Met-Ala-Ser
pH 7.5, 37C, Co2+-containing enzyme
2.4
formyl-Met-Ala-Ser
-
-
2.4
formyl-Met-Ala-Ser
-
Ni2+ PdC
2.6
formyl-Met-Ala-Ser
-
pH 7.6, 25C
4
formyl-Met-Ala-Ser
-
pH 7.6, 25C
4.8
formyl-Met-Ala-Ser
-
pH 7.6, 25C
9.1
formyl-Met-Ala-Ser
-
pH 7.6, 25C
11
formyl-Met-Ala-Ser
-
-
20
formyl-Met-Ala-Ser
-
Zn2+ PdA
21
formyl-Met-Ala-Ser
-
Ni2+ PdA
0.047
formyl-Met-Leu-p-nitroanilide
-
-
1.85
formyl-Met-Thr-Gln-Ser-His
-
-
0.45
formyl-Met-Thr-Met-His
-
-
4
formyl-Met-Thr-Met-His-Thr-Thr
-
-
1.351
formyl-MFAD
-
-
3.01
formyl-MFHQ
-
-
5.14
formyl-MGHQ
-
-
0.521
formyl-MLHQ
-
-
5.76
formyl-MLKL
-
-
4.085
formyl-MMYA
-
-
2.443
formyl-MNFA
-
-
12.44
formyl-MNPL
-
-
24.09
formyl-MPQL
-
-
2.97
formyl-MRHQ
-
-
1.56
formyl-MTHQ
-
-
2.287
formyl-MTHQ
-
-
2.135
formyl-MTMH
-
-
1.181
formyl-MTPM
-
-
52
N-formyl-Ala-Ala-Ala
-
nickel-containing enzyme
0.42
N-formyl-Arg(NH2)
-
enzyme form PDF1A
0.5
N-formyl-Arg(NH2)
-
enzyme form Ni-PDF1B
0.74
N-formyl-Asp(NH2)
-
enzyme form PDF1A
1
N-formyl-Asp(NH2)
-
enzyme form Ni-PDF1B
0.027
N-formyl-beta-thiaphenyl-Lys-p-nitroanilide
-
recombinant Fe2+-bound enzyme
-
0.03
N-formyl-beta-thiaphenyl-Lys-p-nitroanilide
-
recombinant Co2+-bound enzyme
-
0.018
N-formyl-beta-thiaphenyl-lysyl-p-nitroanilide
-
recombinant mutant E133D Co2+-bound enzyme
-
2.9
N-formyl-Gly(NH2)
-
enzyme form PDF1A
4.3
N-formyl-Gly(NH2)
-
enzyme form Ni-PDF1B
2.227
N-formyl-L-Met-L-Ala-L-Ser
Co2+-substituted PDF-1, in 50 mM HEPES, pH 7.5, at 37C
0.052
N-formyl-L-Met-L-Leu-4-nitroanilide
-
in 50 mM potassium phosphate buffer, pH 7.0, temperature not specified in the publication
8.8
N-formyl-L-Met-Val
-
-
0.79
N-formyl-Leu(NH2)
-
enzyme form PDF1A
4.1
N-formyl-Met
-
-
4.1
N-formyl-Met-Ala
-
-
6.2
N-formyl-Met-Ala
-
nickel-containing enzyme
15
N-formyl-Met-Ala
-
-
19
N-formyl-Met-Ala
-
Fe2+-bound enzyme
0.95
N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg
-
-
0.25
N-formyl-Met-Ala-Ser
-
enzyme form PDF1A
0.27
N-formyl-Met-Ala-Ser
-
enzyme form PDF1A
2.3
N-formyl-Met-Ala-Ser
-
enzyme YkrB
2.4
N-formyl-Met-Ala-Ser
-
-
2.5
N-formyl-Met-Ala-Ser
-
mutant enzyme G151D, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
3
N-formyl-Met-Ala-Ser
-
enzyme Def
3.9
N-formyl-Met-Ala-Ser
-
nickel-containing enzyme
4.3
N-formyl-Met-Ala-Ser
-
wild type enzyme, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
4.4
N-formyl-Met-Ala-Ser
-
mutant enzyme G151A, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
5
N-formyl-Met-Ala-Ser
-
wild type enzyme, at pH 7.2 and 37C
5.6
N-formyl-Met-Ala-Ser
-
enzyme form Ni-PDF1B
7.8
N-formyl-Met-Ala-Ser
-
mutant enzyme G49C, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
8.2
N-formyl-Met-Ala-Ser
-
enzyme form PDF1B
9.2
N-formyl-Met-Ala-Ser
-
mutant enzyme F134C, at pH 7.2 and 37C
9.3
N-formyl-Met-Ala-Ser
-
mutant enzyme R137S, at pH 7.2 and 37C
22.37
N-formyl-Met-Ala-Ser
-
truncated PDF-1DeltaN37, in 50 mM KH2PO4, pH 7.5, at 37C
48
N-formyl-Met-Ala-Ser
-
mutant enzyme F134C/R137S, at pH 7.2 and 37C
8
N-formyl-Met-Leu-Glu
-
enzyme form PDF1A
12
N-formyl-Met-Leu-Glu
-
enzyme form Ni-PDF1B
2.64
N-formyl-Met-Leu-NH2
-
recombinant Fe2+-bound enzyme
0.23
N-Formyl-Met-Leu-Phe
-
enzyme form PDF1A
4
N-formyl-Met-Lys
-
nickel-containing enzyme
2
N-formyl-Met-Ser-Asn-Glu
-
enzyme form Ni-PDF1B
4.1
N-formyl-Met-Ser-Asn-Glu
-
enzyme form PDF1A
5.5
N-formyl-Met-Ser-Asn-Glu
-
nickel-containing enzyme
7.1
N-Formyl-Met-Val
-
truncated cobalt deformylase
8
N-Formyl-Met-Val
-
truncated zinc deformylase
12.4
N-Formyl-Met-Val
-
full-length cobalt deformylase
2.5
N-formyl-methionine
-
nickel-containing enzyme
1.3
N-formyl-Nle-Ala(NH2)
-
-
0.6
N-formyl-Nle-Ala-Ser
-
enzyme form PDF1A
3.5
N-formyl-Nle-Ala-Ser
-
nickel-containing enzyme
11
N-formyl-Nle-Ala-Ser
-
enzyme form Ni-PDF1B
0.66
N-formyl-Nle-Arg(NH2)
-
-
8.2
N-formyl-Nle-Asn(NH2)
-
-
4.3
N-formyl-Nle-Asp(NH2)
-
-
1.5
N-formyl-Nle-Gln(NH2)
-
-
4.3
N-formyl-Nle-Glu(NH2)
-
-
5.5
N-formyl-Nle-Gly(NH2)
-
-
1.8
N-formyl-Nle-Leu(NH2)
-
-
0.62
N-formyl-Nle-Lys(NH2)
-
-
1.7
N-formyl-Nle-Met(NH2)
-
-
2.9
N-formyl-Nle-Nle(NH2)
-
-
3
N-formyl-Nle-Phe(NH2)
-
-
3.7
N-formyl-Nle-Pro(NH2)
-
-
1
N-formyl-Nle-Ser(NH2)
-
-
1.8
N-formyl-Nle-Ser(NH2)
-
-
1.6
N-formyl-Nle-Thr(NH2)
-
-
1.9
N-formyl-Nle-Trp(NH2)
-
-
3.3
N-formyl-Nle-Tyr(NH2)
-
-
1.9
N-formyl-Nle-Val(NH2)
-
-
9.4
N-formyl-Nva-Ala-Ser
-
enzyme form PDF1A
3
N-formyl-Phe-Ala-Ser
-
enzyme form PDF1A
0.49
N-formyl-Phe-Tyr-Phe-His-beta-alanine-Arg
-
-
0.42
N-formyl-Ser(NH2)
-
enzyme form PDF1A
1
N-formyl-Ser(NH2)
-
enzyme form Ni-PDF1B
0.037
N-formyl-thiaphenyl-Ala-Leu-p-nitroanilide
-
-
0.53
N-formyl-thiaphenylalanyl-peptide
-
-
0.018
N-formylmethionyl-Leu-p-nitroanilide
-
recombinant Co2+-bound enzyme
0.02
N-formylmethionyl-Leu-p-nitroanilide
-
recombinant Fe2+-bound enzyme
0.02
N-formylmethionyl-Leu-p-nitroanilide
-
-
0.028
N-formylmethionyl-Leu-p-nitroanilide
-
recombinant mutant E133D Co2+-bound enzyme
7.36
N-formylmethionylleucyl-NH2
-
recombinant Co2+-bound enzyme
0.738
formyl-MVHQ
-
-
additional information
additional information
-
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.17
formyl-L-Met-Leu-p-nitroanilide
Homo sapiens
-
-
0.0831
formyl-MAHA
Homo sapiens
-
-
0.00937
formyl-MEHQ
Homo sapiens
-
-
0.08
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R79A
0.24
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R79K
0.6
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R77D
0.8
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R78D
1.6
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R77A; mutant R78K
1.7
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R78A
1.8
formyl-Met-Ala
Mycobacterium tuberculosis
-
mutant R77K
5
formyl-Met-Ala
Mycobacterium tuberculosis
-
wild-type
0.57
formyl-Met-Ala-His-Ala-Ala-Gln
Homo sapiens
-
-
0.0081
formyl-Met-Ala-Ser
Homo sapiens
-
-
3.4
formyl-Met-Ala-Ser
Helicobacter pylori
Q672W7
pH 7.5, 37C, Co2+-containing enzyme
5
formyl-Met-Ala-Ser
Leptospira interrogans
-
-
103
formyl-Met-Ala-Ser
Escherichia coli
-
pH7.6, 25C
152
formyl-Met-Ala-Ser
Staphylococcus aureus
-
pH7.6, 25C
322
formyl-Met-Ala-Ser
Haemophilus influenzae
-
pH7.6, 25C
332
formyl-Met-Ala-Ser
Streptococcus pneumoniae
-
pH7.6, 25C
0.00046
formyl-Met-Leu-p-nitroanilide
Homo sapiens
-
-
1.5
formyl-Met-Thr-Gln-Ser-His
Homo sapiens
-
-
2.2
formyl-Met-Thr-Met-His-Thr-Thr
Homo sapiens
-
-
0.057
formyl-MFAD
Homo sapiens
-
-
0.0134
formyl-MFHQ
Homo sapiens
-
-
0.0155
formyl-MGHQ
Homo sapiens
-
-
0.00275
formyl-MLHQ
Homo sapiens
-
-
0.0049
formyl-MLKL
Homo sapiens
-
-
0.0646
formyl-MMYA
Homo sapiens
-
-
0.0502
formyl-MNFA
Homo sapiens
-
-
0.0211
formyl-MNPL
Homo sapiens
-
-
0.0283
formyl-MPQL
Homo sapiens
-
-
0.0202
formyl-MRHQ
Homo sapiens
-
-
0.0277
formyl-MTHQ
Homo sapiens
-
-
0.044
formyl-MTHQ
Homo sapiens
-
-
0.0362
formyl-MTMH
Homo sapiens
-
-
0.0174
formyl-MTPM
Homo sapiens
-
-
0.45
N-formyl-1-(1-naphthyl)ethylamine
Escherichia coli
-
pH 7.2, 37C
7.1
N-formyl-3-amino-3-phenylpropionic acid
Escherichia coli
-
pH 7.2, 37C
5.7
N-formyl-Ala-Ala-Ala
Escherichia coli
-
nickel-containing enzyme
0.22
N-formyl-alaninol
Escherichia coli
-
pH 7.2, 37C
0.045
N-formyl-alpha-methyl-phenylglycine amide
Escherichia coli
-
pH 7.2, 37C
140
N-formyl-L-Met-L-Ala-L-Ser
Staphylococcus epidermidis
Q5HPX6, Q5HQ78
Co2+-substituted PDF-1, in 50 mM HEPES, pH 7.5, at 37C
1370
N-formyl-m-methoxyphenylalanine nitrile
Escherichia coli
-
pH 7.2, 37C
232
N-formyl-Met-Ala
Escherichia coli
-
nickel-containing enzyme
2100
N-formyl-Met-Ala
Escherichia coli
-
recombinant Fe2+-bound enzyme
1030
N-formyl-Met-Ala-Phe-Tyr-beta-Ala-Arg
Escherichia coli
-
-
0.07
N-formyl-Met-Ala-Ser
Bacillus subtilis
-
enzyme Def
0.093
N-formyl-Met-Ala-Ser
Trypanosoma cruzi
-
truncated PDF-1DeltaN37, in 50 mM KH2PO4, pH 7.5, at 37C
0.17
N-formyl-Met-Ala-Ser
Bacillus subtilis
-
enzyme YkrB
2
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
mutant enzyme G49C, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
3.5
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
mutant enzyme G151A, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
3.6
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
wild type enzyme, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
4.5
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
mutant enzyme G151D, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
5
N-formyl-Met-Ala-Ser
Leptospira interrogans
-
-
6.4
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
wild type enzyme, at pH 7.2 and 37C
13
N-formyl-Met-Ala-Ser
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
15
N-formyl-Met-Ala-Ser
Solanum lycopersicum
-
enzyme form PDF1A
19.6
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
mutant enzyme F134C, at pH 7.2 and 37C
22
N-formyl-Met-Ala-Ser
Arabidopsis thaliana
-
enzyme form PDF1A
22.1
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
mutant enzyme R137S, at pH 7.2 and 37C
45.3
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
mutant enzyme F134C/R137S, at pH 7.2 and 37C
75
N-formyl-Met-Ala-Ser
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
210
N-formyl-Met-Ala-Ser
Escherichia coli
-
nickel-containing enzyme
1.1
N-formyl-Met-Leu-Glu
Arabidopsis thaliana
-
enzyme form PDF1A
9.2
N-formyl-Met-Leu-Glu
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
1280
N-formyl-Met-Leu-NH2
Escherichia coli
-
recombinant Co2+-bound enzyme
1320
N-formyl-Met-Leu-NH2
Escherichia coli
-
recombinant Fe2+-bound enzyme
19
N-formyl-Met-Leu-p-nitroanilide
Escherichia coli
-
recombinant Co2+-bound enzyme
38
N-formyl-Met-Leu-p-nitroanilide
Escherichia coli
-
-
0.7
N-Formyl-Met-Leu-Phe
Arabidopsis thaliana
-
enzyme form PDF1A
197
N-formyl-Met-Lys
Escherichia coli
-
nickel-containing enzyme
1.9
N-formyl-Met-Ser-Asn-Glu
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
11
N-formyl-Met-Ser-Asn-Glu
Arabidopsis thaliana
-
enzyme form PDF1A
175
N-formyl-Met-Ser-Asn-Glu
Escherichia coli
-
nickel-containing enzyme
0.21
N-formyl-methionine
Escherichia coli
-
nickel-containing enzyme
270
N-formyl-Nle-Ala(NH2)
Escherichia coli
-
-
26
N-formyl-Nle-Ala-Ser
Arabidopsis thaliana
-
enzyme form PDF1A
136
N-formyl-Nle-Ala-Ser
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
218
N-formyl-Nle-Ala-Ser
Escherichia coli
-
nickel-containing enzyme
5
N-formyl-Nle-Arg(NH2)
Arabidopsis thaliana
-
enzyme form PDF1A
138
N-formyl-Nle-Arg(NH2)
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
300
N-formyl-Nle-Arg(NH2)
Escherichia coli
-
-
320
N-formyl-Nle-Asn(NH2)
Escherichia coli
-
-
0.4
N-formyl-Nle-Asp(NH2)
Arabidopsis thaliana
-
enzyme form PDF1A
6.4
N-formyl-Nle-Asp(NH2)
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
120
N-formyl-Nle-Asp(NH2)
Escherichia coli
-
-
280
N-formyl-Nle-Gln(NH2)
Escherichia coli
-
-
200
N-formyl-Nle-Glu(NH2)
Escherichia coli
-
-
1.4
N-formyl-Nle-Gly(NH2)
Arabidopsis thaliana
-
enzyme form PDF1A
260
N-formyl-Nle-Gly(NH2)
Escherichia coli
-
-
250
N-formyl-Nle-His(NH2)
Escherichia coli
-
-
0.36
N-formyl-Nle-Leu(NH2)
Arabidopsis thaliana
-
enzyme form PDF1A
150
N-formyl-Nle-Leu(NH2)
Escherichia coli
-
-
230
N-formyl-Nle-Lys(NH2)
Escherichia coli
-
-
190
N-formyl-Nle-Met(NH2)
Escherichia coli
-
-
210
N-formyl-Nle-Nle(NH2)
Escherichia coli
-
-
200
N-formyl-Nle-Phe(NH2)
Escherichia coli
-
-
150
N-formyl-Nle-Pro(NH2)
Escherichia coli
-
-
10
N-formyl-Nle-Ser(NH2)
Arabidopsis thaliana
-
enzyme form PDF1A
51
N-formyl-Nle-Ser(NH2)
Arabidopsis thaliana
-
enzyme form Ni-PDF1B
170
N-formyl-Nle-Ser(NH2)
Escherichia coli
-
-
180
N-formyl-Nle-Thr(NH2)
Escherichia coli
-
-
130
N-formyl-Nle-Trp(NH2)
Escherichia coli
-
-
140
N-formyl-Nle-Tyr(NH2)
Escherichia coli
-
-
160
N-formyl-Nle-Val(NH2)
Escherichia coli
-
-
18
N-formyl-Nva-Ala-Ser
Arabidopsis thaliana
-
enzyme form PDF1A
0.6
N-formyl-Phe-Ala-Ser
Arabidopsis thaliana
-
enzyme form PDF1A
204
N-formyl-Phe-Tyr-Phe-His-beta-Ala-Arg
Escherichia coli
-
-
880
N-formyl-phenylalanine nitrile
Escherichia coli
-
pH 7.2, 37C
10.6
N-formyl-phenylglycine
Escherichia coli
-
pH 7.2, 37C
227
N-formyl-phenylglycine amide
Escherichia coli
-
pH 7.2, 37C
0.69 - 6.3
N-formyl-phenylglycinol
Escherichia coli
-
pH 7.2, 37C
6.08
N-formyl-phenylglycinol
Escherichia coli
-
pH 7.2, 37C
0.15
N-formyl-tert-leucine amide
Escherichia coli
-
pH 7.2, 37C
3.5
N-formyl-thiaphenylalanyl-peptide
Escherichia coli
-
-
26
N-formyl-thiaphenylalanylleucyl-p-nitroanilide
Escherichia coli
-
-
29.7
N-formyl-valine nitrile
Escherichia coli
-
pH 7.2, 37C
4.2
N-formylmethionylleucyl-p-nitroanilide
Escherichia coli
-
recombinant mutant E133D Co2+-bound enzyme
70
N-formylmethionylleucyl-p-nitroanilide
Escherichia coli
-
recombinant Fe2+-bound enzyme
0.00581
formyl-MVHQ
Homo sapiens
-
-
additional information
additional information
Arabidopsis thaliana
-
-
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
63
N-formyl-L-Met-L-Ala-L-Ser
Staphylococcus epidermidis
Q5HPX6, Q5HQ78
Co2+-substituted PDF-1, in 50 mM HEPES, pH 7.5, at 37C
36627
0.26
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
mutant enzyme G49C, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
2050
0.795
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
mutant enzyme G151A, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
2050
0.842
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
wild type enzyme, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
2050
0.948
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
mutant enzyme F134C/R137S, at pH 7.2 and 37C
2050
1.296
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
wild type enzyme, at pH 7.2 and 37C
2050
1.786
N-formyl-Met-Ala-Ser
Mycobacterium tuberculosis
-
mutant enzyme G151D, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
2050
2.143
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
mutant enzyme F134C, at pH 7.2 and 37C
2050
2.387
N-formyl-Met-Ala-Ser
Chlamydia trachomatis
-
mutant enzyme R137S, at pH 7.2 and 37C
2050
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.052
(1-hydroxyaminomethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
0.11
(1-hydroxyaminomethyl-2-phenylethyl)carbamic acid tert-butyl ester
AtPDF2
0.000044
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
0.00005
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
0.0003
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
AtPDF2
0.0004
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
AtPDF2
0.083
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
0.15
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
0.000011
(2R)-N-[(1S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
-
DPPI assay
0.000039
(2R)-N-[(1S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
-
Zn-BbPDF1-HT
0.000074
(2R)-N-[(1S)-5-amino-1-(hexylcarbamoyl)pentyl]-2-[[formyl(hydroxy)amino]methyl]heptanamide
-
DPPI assay
0.00015
(R)-2-[(formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-5-amino-1-phenylcarbamoyl-pentyl)-amide
-
-
0.000045
(R)-2-[(formyl-hydroxy-amino)-methyl]-hexanoic acid [(S)-5-amino-1-((R)-2-isopropoxymethyl-pyrrolidine-1-carbonyl)-pentyl]-amide
-
-
0.000036
(R)-2-[(formyl-hydroxy-amino)-methyl]-hexanoic acid [(S)-5-amino-1-((S)-2-isopropoxymethyl-pyrrolidine-1-carbonyl)-pentyl]-amide
-
-
0.17
1,10-phenanthroline
-
-
0.004
1,2-Ethanedithiol
-
-
0.0029
1,3-propanedithiol
-
-
0.038
1,5-pentanedithiol
-
-
0.25
1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one
AtPDF2
0.56
1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one
-
0.79
1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one
-
0.0402
2,3-dimercapto-1-propanesulfonic acid
-
-
0.0109
2,3-dimercapto-1-propanol
-
-
0.0001
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
0.002
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
0.7
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
0.000013
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
0.000035
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
0.13
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
0.36
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
0.0001
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
AtPDF2
0.003
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
0.45
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
0.45
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
-
0.000015
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
0.00008
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
0.25
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
0.6
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
-
0.00002
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
0.00016
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
0.7
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
0.00033
2-(5-methoxy-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
0.009
2-(5-methoxy-1H-indol-3-yl)-N-hydroxyacetamide
-
0.00003
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
AtPDF2
0.00021
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
0.25
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
0.25
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
-
0.0003
2-(indol-3-yl)-N-hydroxyacetamide
AtPDF2
0.0014
2-(indol-3-yl)-N-hydroxyacetamide
-
0.17
2-amino-5-mercapto-1,3,4-thiadiazole
-
in 50 mM potassium phosphate buffer, pH 7.0, temperature not specified in the publication
0.1
3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester
AtPDF2
0.35
3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester
-
0.5
3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester
-
0.28
3-carboxymethylindol-1-carboxylic acid benzyl ester
AtPDF2
0.3
3-carboxymethylindol-1-carboxylic acid benzyl ester
-
0.0012
3-[5'-benzyl-2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
-
-
0.006
5-(1,1-dimethyl-propyl)-4'-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl)-biphenyl-2-sulfonylcarbamate
-
-
-
0.000018
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
AtPDF2
0.000027
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
-
0.014
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
-
0.000027
actinonin
-
0.00014
actinonin
-
at 37C, pH not specified in the publication
0.00015
actinonin
-
Ni2+ PdfB
0.000281
actinonin
-
Zn2+ PdC
0.00058
actinonin
-
Ni2+ PdC
0.0006
actinonin
-
-
0.0012
actinonin
-
Ni2+ PdfA
0.000008
BB-3497
-
-
0.00014
BB-3497
-
Zn2+ PdfC
0.000203
BB-3497
-
Ni2+ PdfB
0.00094
BB-3497
-
Ni2+ PdfA
0.0016
BB-3497
-
Ni2+ PdfC
0.04
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme I44F
0.052
methyl-1-(sulfanylmethyl)hexanoate
-
wild-type enzyme and mutant enzyme E88A
0.08
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme C129W
0.18
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme L125W
0.6
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme I86F
0.64
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme L125A
1.5
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme I1289S
2
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme I128R
10
methyl-1-(sulfanylmethyl)hexanoate
-
mutant enzyme I128F
0.0004
N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine
AtPDF2
0.006
N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine
-
0.5
N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine
-
0.000025
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
AtPDF2
0.00003
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
0.035
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
0.2
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
-
0.000077
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloheptadec-6-yl)-methyl-N-hydroxy-formamide
-
DPPI assay
0.000096
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclohexadec-6-yl)-methyl-N-hydroxy-formamide
-
DPPI assay
0.0021
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloicos-6-yl)-methyl-N-hydroxy-formamide
-
DPPI assay
0.000109
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl)-methyl-N-hydroxy-formamide
-
DPPI assay
0.000063
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclotridec-6-yl)-methyl-N-hydroxy-formamide
-
DPPI assay
0.0095
N-benzyloxycarbonyl-Leu-norleucinal
-
cobalt-substituted enzyme
-
0.0124
N-benzyloxycarbonyl-Leu-norleucinal
-
cobalt-substituted enzyme
-
0.026
N-benzyloxycarbonyl-Leu-norleucinal
-
-
-
0.0556
N-benzyloxycarbonyl-Leu-norleucinal
-
-
-
0.000148
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
-
mutant enzyme R137S, at pH 7.2 and 37C
0.00016
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
-
wild type enzyme, at pH 7.2 and 37C
0.001
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
-
mutant enzyme F134C/R137S, at pH 7.2 and 37C
143
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide
-
mutant enzyme F134C, at pH 7.2 and 37C
0.001
N-[2-(5-bromo-2-methyl-1H-indole-3-yl)methyl]hydroxylamine
AtPDF2
0.05
N-[2-(5-bromo-2-methyl-1H-indole-3-yl)methyl]hydroxylamine
-
0.00071
N-[3-(4-acetamidobutyl)-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl]methyl-N-hydroxy-formamide
-
DPPI assay
0.000258
N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacycloicos-6-yl]methyl-N-hydroxyformamide
-
DPPI assay
0.000092
N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacyclopentadec-6-yl]methyl-N-hydroxyformamide
-
DPPI assay
0.03
N-[4-(trifluoromethyl)benzoyl]-L-Met
-
-
0.0116
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide
-
truncated Zn-PDF
0.0118
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide
-
truncated Co-PDF
0.2
N-[4-(trifluoromethyl)benzoyl]-L-methionyl hydrazide
-
full-lenfth Co-PDF
0.00002
N-[[(3S,6R)-3-tert-butyl-2,5-dioxo-1,4-diazacyclopentadecan-6-yl]methyl]-N-hydroxyformamide
-
Zn-BbPDF1-HT
0.000023
N2-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-phenyl-L-lysinamide
-
DPPI assay
6
Polyethylene glycol
-
-
0.12
thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester
; AtPDF2
0.17
thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester
-
0.2
thioacetic acid S-[3-(indol-3-yl)-2-oxopropyl] ester
; AtPDF2
35
ZnCl2
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000002
(2R)-N4-hydroxy-N1-[(2R)-1-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000049
(3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000803
(3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid
Mycobacterium tuberculosis
P9WIJ3
-
0.000018
(3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000202
(3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid
Mycobacterium tuberculosis
P9WIJ3
-
0.00125
(E)-N-phenethyl-3-(3,4-diacetoxyphenyl)acrylamide
Helicobacter pylori
Q672W7
IC50: 0.00125 mM
0.0001
(RS)- and (SR)-3-[(RS)-benzenesulfinyl]heptanoic acid hydroxyamide
Escherichia coli
-
mixture of both components, IC50: 0.0001 mM, possible antimicrobial agent
0.000035
(RS)-3-(phenylsulfonyl)heptanoic acid hydroxyamide
Escherichia coli
-
IC50: 0.035 micro molar, possible antimicrobial agent
0.0000013
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2,2-dimethylpropanoyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00001
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2,2-dimethylpropanoyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000018
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2,2-dimethylpropanoyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000015
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2-methylpropanoyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000005
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2-methylpropanoyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00001
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(2-methylpropanoyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000008
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(3-methylbutanoyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000004
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(3-methylbutanoyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000007
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(3-methylbutanoyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000012
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(cyclopropylcarbonyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000023
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(cyclopropylcarbonyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000055
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(cyclopropylcarbonyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00000054
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethoxycarbonyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000022
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethoxycarbonyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000077
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethoxycarbonyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000044
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethylcarbamoyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000002
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethylcarbamoyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000049
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(ethylcarbamoyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000001
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxyacetyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000008
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxyacetyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000013
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxyacetyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000019
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxycarbonyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000045
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxycarbonyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000013
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methoxycarbonyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000046
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methylcarbamoyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000021
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methylcarbamoyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000061
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(methylcarbamoyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000021
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(prop-2-en-1-ylcarbamoyl)-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00001
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(prop-2-en-1-ylcarbamoyl)-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00002
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-(prop-2-en-1-ylcarbamoyl)-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000011
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(2-hydroxyethyl)carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000038
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(2-hydroxyethyl)carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000088
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(2-hydroxyethyl)carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000077
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-hydroxypropyl)carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000032
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-hydroxypropyl)carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000069
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-hydroxypropyl)carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000019
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-phenylpropyl)carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000001
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-phenylpropyl)carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000041
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(3-phenylpropyl)carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000026
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(cyclopentyloxy)carbonyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000014
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(cyclopentyloxy)carbonyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000031
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(cyclopentyloxy)carbonyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000048
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(propan-2-yloxy)carbonyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000002
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(propan-2-yloxy)carbonyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000047
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(propan-2-yloxy)carbonyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000066
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(tetrahydro-2H-pyran-4-yloxy)carbonyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000031
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(tetrahydro-2H-pyran-4-yloxy)carbonyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000044
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[(tetrahydro-2H-pyran-4-yloxy)carbonyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000015
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(1H-imidazol-4-yl)ethyl]carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000013
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(1H-imidazol-4-yl)ethyl]carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000043
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(1H-imidazol-4-yl)ethyl]carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000041
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyrazin-2-yl)ethyl]carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000014
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyrazin-2-yl)ethyl]carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000061
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyrazin-2-yl)ethyl]carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000035
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-2-yl)ethyl]carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000014
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-2-yl)ethyl]carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000059
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-2-yl)ethyl]carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000037
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-3-yl)ethyl]carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000014
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-3-yl)ethyl]carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000047
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-3-yl)ethyl]carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000035
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-4-yl)ethyl]carbamoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000017
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-4-yl)ethyl]carbamoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000044
1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-N-[[2-(pyridin-4-yl)ethyl]carbamoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0041
2',2'-bisepigallocatechin monogallate
Homo sapiens
-
fluorescence polarization assay
0.002
2-(1-benzyl-5-chloro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.002 mM
0.00059
2-(1-butyl-5-chloro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00059 mM
0.00076
2-(2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00076 mM
0.000012
2-(4-benzyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-oxoacetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000058
2-(4-[2-[(2,5-difluorophenyl)amino]-2-oxoethyl]-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-oxoacetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000069
2-(5-bromo-1-cyclopropyl-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.000069 mM
0.000098
2-(5-bromo-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.000098 mM
0.000049
2-(5-bromo-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.000049 mM
0.00011
2-(5-chloro-1-cyclopropyl-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00011 mM
0.00012
2-(5-chloro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
inhibitor shows good selectivity for peptide deformylase over several endoproteases including matrix metalloproteases, however it shows only weak antibacterial activity. IC50: 0.00012 mM
0.00031
2-(5-chloro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)-N-hydroxyacetamide
Escherichia coli
-
inhibitor shows good selectivity for peptide deformylase over several endoproteases including matrix metalloproteases, however it shows only weak antibacterial activity. IC50: 0.00031 mM
0.027
2-(5-chloro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide
Escherichia coli
-
IC50: 0.027 mM
0.00087
2-(5-fluoro-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00087 mM
0.00087
2-(5-fluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00087 mM
0.05
2-(biphenyl-4-yl)-N-oxoacetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0076
2-butyl-5,7-dimethyl-3-[2''-(1H-tetrazol-5-ylmethyl)-[1,1',4',1'']terphenyl-4-yl]-3H-imidazo[4,5-b]pyridine
Escherichia coli
-
belongs to a class of angiotensin II receptor antagonists, potent inhibitor, IC50: 0.0076 mM
0.00000012
2-phenylethanamine
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00000086
2-phenylethanamine
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000036
2-phenylethanamine
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00166
2-thioxo-4-thiazolidinone N-hexanoic acid
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.00166 mM
0.00013
2-[2,2-dioxido-5-(trifluoromethyl)-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00013 mM
0.00005
2-[4-(3,3-dimethyl-2-oxobutyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-oxoacetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000005
2-[4-(3-methylbutyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-oxoacetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000041
2-[4-(cyclobutylmethyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-oxoacetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.00029
2-[5-chloro-2,2-dioxido-1-(3-phenylpropyl)-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-hydroxyacetamide
Escherichia coli
-
IC50: 0.00029 mM
0.031
3-methoxycatechol
Homo sapiens
-
fluorescence polarization assay
0.000043
3-methyl-N-(1,3-thiazol-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000052
3-methyl-N-(2-methylpropanoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000028
3-methyl-N-(morpholin-4-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000017
3-methyl-N-(phenylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000047
3-methyl-N-(piperidin-1-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000054
3-methyl-N-(pyridin-2-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000049
3-methyl-N-(pyridin-3-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000065
3-methyl-N-(pyridin-4-ylcarbamoyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000019
3-methyl-N-(thiophen-2-ylcarbonyl)-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.00005
3-methyl-N-[methyl(phenyl)carbamoyl]-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.0342
3-[5'-benzyl-2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
Escherichia coli
-
potent inhibitor, IC50: 0.0342 mM, the acidic moiety forms direct ionic interactions with active site metal cation
0.015
5-(1,1-dimethyl-propyl)-4'-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl)-biphenyl-2-sulfonylcarbamate
Escherichia coli
-
competitive inhibition, IC50: 0.015 mM, the acidic moiety forms direct ionic interactions with active site metal cation
-
0.0039
5-chloro-2-propyl-3-[2''-(1H-tetrazol-5-ylmethyl)-[1,1',4',1'']terphenyl-4-yl]-3H-imidazo[4,5-b]pyridine
Escherichia coli
-
belongs to a broad class of angiotensin II receptor antagonists, potent competitive inhibitor, IC50: 0.0039 mM, the acidic moiety forms direct ionic interactions with active site metal cation
0.0038
5-[[(2-chlorophenyl)sulfanyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.002
5-[[(3,4-dichlorophenyl)sulfanyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0017
5-[[(3-chlorophenyl)sulfonyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0023
5-[[(4-chlorophenyl)sulfanyl]methyl]-N-hydroxy-1,2-oxazole-3-carboxamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0065
5-[[(4-methoxyphenyl)sulfonyl]methyl]-1,2-oxazole-3-carbohydrazide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.017
7,8-dihydroxyflavone
Homo sapiens
-
fluorescence polarization assay
0.0000003
actinonin
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM
0.000043
actinonin
Homo sapiens
-
competitive, IC50: 43 nM
0.00012
actinonin
Mycobacterium tuberculosis
-
wild type enzyme, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
0.0008
actinonin
Mycobacterium tuberculosis
-
mutant enzyme G151D, in 20 mM phosphate buffer, pH 7.4, temperature not specified in the publication
0.0055
actinonin
Homo sapiens
-
fluorescence polarization assay
0.01
aldehyde peptide
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.01 mM
-
0.000004 - 0.00001
alkyl-succinate-proline hydroxamate
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM
0.000005
benzothiazinone derivatives
Haemophilus influenzae
-
IC50: 0.000005 mM
-
0.00104
benzothiazolylidene hydroxamic acid derivatives
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.00104 mM
-
0.000016
beta-sulfonylhydroxamic acid
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.000016 mM
0.048
chloranil
Homo sapiens
-
fluorescence polarization assay
0.038
epigallocatechin 3,5-digallate
Homo sapiens
-
fluorescence polarization assay
0.029
epitheaflavin monogallate
Homo sapiens
-
fluorescence polarization assay
0.012
hematein
Homo sapiens
-
fluorescence polarization assay
0.0027
hematoxylin
Homo sapiens
-
fluorescence polarization assay
0.0002
hydantoin
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.0002 mM
0.017
irigenol
Homo sapiens
-
fluorescence polarization assay
0.00000019
N-(benzylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000017
N-(benzylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000065
N-(benzylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00023
N-(benzyloxy)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0000003
N-(cyclobutylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000009
N-(cyclobutylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000018
N-(cyclobutylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000007
N-(cyclobutylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000005
N-(cyclobutylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000009
N-(cyclobutylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000002
N-(cyclohexylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000093
N-(cyclohexylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000004
N-(cyclohexylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000055
N-(cyclohexylcarbamoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.0000005
N-(cyclohexylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000037
N-(cyclohexylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000052
N-(cyclohexylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000001
N-(cyclopentylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000052
N-(cyclopentylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000002
N-(cyclopentylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000043
N-(cyclopentylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000025
N-(cyclopentylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000061
N-(cyclopentylcarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00000052
N-(tert-butoxycarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000032
N-(tert-butoxycarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000034
N-(tert-butoxycarbonyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000022
N-(tert-butylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000012
N-(tert-butylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000024
N-(tert-butylcarbamoyl)-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000004
N-acetyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000012
N-acetyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000016
N-acetyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000003
N-alkyl urea hydroxamate
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.000003 mM
0.00000028
N-benzoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000038
N-benzoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000052
N-benzoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000041
N-benzoyl-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.00000091
N-carbamoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000022
N-carbamoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000048
N-carbamoyl-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00032
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
Haemophilus influenzae
-
i.e. SB 543668, IC50: 0.00032 mM
0.00115
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
Escherichia coli
-
i.e. SB 543668, IC50: 0.00115 mM
0.0022
N-formyl-N-hydroxy-2-(3-benzoylphenoxy)ethylamine
Staphylococcus aureus
-
i.e. SB 543668, IC50: 0.0022 mM
0.00015
N-formyl-N-hydroxy-3-phenylpropylamine
Haemophilus influenzae
-
i.e. SB 485345, IC50: 0.00015 mM
0.00016
N-formyl-N-hydroxy-3-phenylpropylamine
Escherichia coli
-
i.e. SB 485345, IC50: 0.00016 mM
0.00025
N-formyl-N-hydroxy-3-phenylpropylamine
Staphylococcus aureus
-
i.e. SB 485345, IC50: 0.00025 mM
0.0022
N-hydroxy urea
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.0022 mM
0.0029
N-hydroxy-2-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide
Escherichia coli
-
IC50: 0.0029 mM
0.00023
N-hydroxy-2-[2-oxo-5-(trifluoromethyl)-1,4-dihydroquinazolin-3(2H)-yl]acetamide
Escherichia coli
-
IC50: 0.00023 mM
0.0076
N-hydroxy-5-([[2-(propan-2-yl)phenyl]sulfanyl]methyl)-1,2-oxazole-3-carboxamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0087
N-hydroxy-5-([[4-(trifluoromethyl)phenyl]sulfanyl]methyl)-1,2-oxazole-3-carboxamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.00104
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
Haemophilus influenzae
-
i.e. SB 505684, IC50: 0.00104 mM
0.00109
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
Staphylococcus aureus
-
i.e. SB 505684, IC50: 0.00109 mM
0.0028
N-hydroxy-N-[3-(6-methylpyridine-2-yl)propyl]formamide
Escherichia coli
-
i.e. SB 505684, IC50: 0.0028 mM
0.000074
N-methoxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.002
N-methoxy-N-methyl-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000005
N-oxo-2-[3-oxo-4-(2-phenylethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.000018
N-oxo-2-[3-oxo-4-(tetrahydro-2H-pyran-2-ylmethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.0004
N-oxo-2-[3-oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.2
N-substituted methionine hydrazide
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.2 mM
0.0108
N-trans-caffeoyltyramine
Helicobacter pylori
Q672W7
IC50: 0.0108 mM
0.00000038
N-[(2-aminoethyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000023
N-[(2-aminoethyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000007
N-[(2-aminoethyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.000042
N-[(2-methoxyethyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000021
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N-hydroxy-N2-(3-methylbutyl)glycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000031
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(2-cyclopentylethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000013
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclobutylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000029
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000015
N-[(2-methoxyphenyl)carbamoyl]-3-methyl-L-valyl-N2-(cyclopropylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000042
N-[(2-methoxyphenyl)carbamoyl]alanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000032
N-[(2-methoxyphenyl)carbamoyl]leucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000036
N-[(2-methoxyphenyl)carbamoyl]norleucyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000061
N-[(2-methoxyphenyl)carbamoyl]phenylalanyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000013
N-[(2-methoxyphenyl)carbamoyl]valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
0.000013
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000013
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000028
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000015
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.00001
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000024
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000021
N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000161
N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000008
N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.000068
N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide
Mycobacterium tuberculosis
P9WIJ3
-
0.00000072
N-[(3-amino-3-oxopropyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000033
N-[(3-amino-3-oxopropyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000063
N-[(3-amino-3-oxopropyl)carbamoyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000051
N-[(cyclobutyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000024
N-[(cyclobutyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000058
N-[(cyclobutyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000003
N-[(cyclohexyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000015
N-[(cyclohexyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.1
naphthalen-1-yl[[3-(trifluoromethyl)benzyl]amino]acetic acid
Staphylococcus aureus
P68826
pH and temperature not specified in the publication
-
0.07
p-chloromercuribenzoate
Escherichia coli
-
potent inhibitor, IC50: 0.07 mM
0.0000014
piperidin-4-yl [1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolyl]carbamate
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000027
piperidin-4-yl [1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolyl]carbamate
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.0000059
piperidin-4-yl [1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolyl]carbamate
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
0.00000031
propan-2-amine
Streptococcus pneumoniae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.0000016
propan-2-amine
Staphylococcus aureus
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.000003
propan-2-amine
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
0.00003
pseudopeptide metabolites
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.000030 mM
-
0.0088
Purpurogallin
Homo sapiens
-
fluorescence polarization assay
0.0057
pyrogallin
Homo sapiens
-
fluorescence polarization assay
0.0089
quinalizarin
Homo sapiens
-
fluorescence polarization assay
0.00012
quinazoline hydroxamic acid
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.00012 mM
0.000072
SKI-AC-1
Homo sapiens
-
IC50: 0.000072 mM, actionin analog
0.000078
SKI-AC-10
Homo sapiens
-
IC50: 0.000078 mM, actionin analog
0.000076
SKI-AC-11101
Homo sapiens
-
IC50: 0.000076 mM, actionin analog
-
0.00006
SKI-AC-111101
Homo sapiens
-
IC50: 0.0000600 mM, actionin analog
0.000427
SKI-AC-111110
Homo sapiens
-
IC50: 0.000427 mM, actionin analog
-
0.000069
SKI-AC-111111
Homo sapiens
-
IC50: 0.000069 mM, actionin analog
0.000234
SKI-AC-111112
Homo sapiens
-
IC50: 0.000234 mM, actionin analog
-
0.000177
SKI-AC-111113
Homo sapiens
-
IC50: 0.000177 mM, actionin analog
-
0.0003
SKI-AC-111114
Homo sapiens
-
IC50: 0.000300 mM, actionin analog
-
0.000365
SKI-AC-11112
Homo sapiens
-
IC50: 0.000365 mM, actionin analog
-
0.0005
SKI-AC-11113
Homo sapiens
-
IC50: 0.000500 mM, actionin analog
-
0.000276
SKI-AC-11114
Homo sapiens
-
IC50: 0.000276 mM, actionin analog
-
0.000473
SKI-AC-11115
Homo sapiens
-
IC50: 0.000473 mM, actionin analog
-
0.000335
SKI-AC-11116
Homo sapiens
-
IC50: 0.000335 mM, actionin analog
-
0.000086
SKI-AC-11117
Homo sapiens
-
IC50: 0.000086 mM, actionin analog
0.000115
SKI-AC-11118
Homo sapiens
-
IC50: 0.000115 mM, actionin analog
0.000134
SKI-AC-11119
Homo sapiens
-
IC50: 0.000134 mM, actionin analog
-
0.000522
SKI-AC-11128
Homo sapiens
-
IC50: 0.000522 mM, actionin analog
-
0.0005
SKI-AC-11138
Homo sapiens
-
IC50: 0.000500 mM, actionin analog
-
0.00006
SKI-AC-11148
Homo sapiens
-
IC50: 0.0000600 mM, actionin analog
-
0.0005
SKI-AC-11158
Homo sapiens
-
IC50: 0.000500 mM, actionin analog
-
0.000192
SKI-AC-11168
Homo sapiens
-
IC50: 0.000192 mM, actionin analog
-
0.0002
SKI-AC-11178
Homo sapiens
-
IC50: 0.000200 mM, actionin analog
-
0.00012
SKI-AC-11188
Homo sapiens
-
IC50: 0.000120 mM, actionin analog
-
0.00009
SKI-AC-11198
Homo sapiens
-
IC50: 0.000090 mM, actionin analog
0.0005
SKI-AC-3
Homo sapiens
-
IC50: 0.000500 mM, actionin analog
-
0.0004
SKI-AC-5, SKI-AC-51121
Homo sapiens
-
IC50: 0.000400 mM, actionin analog
-
0.000097
SKI-AC-6
Homo sapiens
-
IC50: 0.000097 mM, actionin analog
0.000093
SKI-AC-8
Homo sapiens
-
IC50: 0.000093 mM, actionin analog
0.000151
SKI-AC-9
Homo sapiens
-
IC50: 0.000151 mM, actionin analog
-
0.000404
SKI-AC-I-18
Homo sapiens
-
IC50: 0.000404 mM, actionin analog
-
0.000239
SKI-AC-I-19
Homo sapiens
-
IC50: 0.000239 mM, actionin analog
-
0.0061
theaflavin
Homo sapiens
-
fluorescence polarization assay
0.0071
theaflavin monogallate
Homo sapiens
-
fluorescence polarization assay
0.000019
thio peptide
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif
-
0.0025
thiol peptide
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified
-
0.5
Thiophenol
Escherichia coli
-
IC50: 0.5 mM
0.043
thiram
Homo sapiens
-
fluorescamine assay
0.001
thyropropic acid derivatives
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.001 mM
-
0.000116
1-[(2-methoxyphenyl)carbamoyl]prolyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(2-methylphenyl)-L-prolinamide
Staphylococcus aureus
-
6.25 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(2-methylphenyl)-L-prolinamide
Staphylococcus enteridis
-
larger than 6.25 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(2-methylphenyl)-L-prolinamide
Staphylococcus epidermidis
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(2-methylphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
larger than 6.25 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(2-methylphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(3-methylphenyl)-L-prolinamide
Staphylococcus aureus
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(3-methylphenyl)-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(3-methylphenyl)-L-prolinamide
Staphylococcus epidermidis
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(3-methylphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(3-methylphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methoxyphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis
-
0.78 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methoxyphenyl)-L-prolinamide
Staphylococcus epidermidis
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methoxyphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
6.25 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methoxyphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methylphenyl)-L-prolinamide
Staphylococcus epidermidis
-
0.78 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methylphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-methylphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-morpholin-4-ylphenyl)-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-morpholin-4-ylphenyl)-L-prolinamide
Staphylococcus enteridis, Staphylococcus epidermidis
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-morpholin-4-ylphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-morpholin-4-ylphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-piperidin-1-ylphenyl)-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-piperidin-1-ylphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-piperidin-1-ylphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-pyrrolidin-1-ylphenyl)-L-prolinamide
Staphylococcus aureus
-
0.78 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-pyrrolidin-1-ylphenyl)-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-pyrrolidin-1-ylphenyl)-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-pyrrolidin-1-ylphenyl)-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-(4-pyrrolidin-1-ylphenyl)-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
Staphylococcus enteridis
-
0.049 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
Staphylococcus epidermidis
-
0.195 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(1H-pyrrol-1-yl)phenyl]-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]-L-prolinamide
Staphylococcus enteridis
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-oxidomorpholin-4-yl)phenyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus
-
larger than 6.25 microg/ml
additional information
1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-[4-(4-oxidomorpholin-4-yl)phenyl]-L-prolinamide
Streptococcus pneumoniae
-
3.13 microg/ml
0.0034
isoxazole-3-hydroxamic acid derivatives
Haemophilus influenzae
-
IC50 against Escherichia coli peptide deformylase: 0.0034 mM
-
additional information
LBM-415
Staphylococcus aureus
-
0.39 microg/ml
additional information
LBM-415
Staphylococcus enteridis
-
3.13 microg/ml
additional information
LBM-415
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
LBM-415
Staphylococcus non-hemolyticus
-
0.78 microg/ml
additional information
LBM-415
Streptococcus pneumoniae
-
0.195 microg/ml
0.000011
N-(2-methoxybenzoyl)-3-methyl-L-valyl-N2-(cyclopentylmethyl)-N-hydroxyglycinamide
Pseudomonas aeruginosa
Q9I7A8
pH and temperature not specified in the publication
additional information
N-(3,4-difluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis
-
0.39 microg/ml
additional information
N-(3,4-difluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.195 microg/ml
additional information
N-(3,4-difluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
6.25 microg/ml
additional information
N-(3,4-difluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.195 microg/ml
additional information
N-(3-chloro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
N-(3-chloro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis, Staphylococcus epidermidis
-
0.195 microg/ml
additional information
N-(3-chloro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
larger than 6.25 microg/ml
additional information
N-(3-chloro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.195 microg/ml
additional information
N-(3-chloro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.195 microg/ml
additional information
N-(3-chloro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
N-(3-chloro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.195 microg/ml
additional information
N-(3-chloro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
N-(3-chloro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
N-(3-chloro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis, Staphylococcus non-hemolyticus
-
0.195 microg/ml
additional information
N-(3-chloro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
N-(3-fluoro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
N-(3-fluoro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
3.13 microg/ml
additional information
N-(3-fluoro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
N-(3-fluoro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
larger than 6.25 microg/ml
additional information
N-(3-fluoro-4-morpholin-4-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
N-(3-fluoro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis, Staphylococcus epidermidis
-
0.39 microg/ml
additional information
N-(3-fluoro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
N-(3-fluoro-4-piperidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
N-(3-fluoro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
N-(3-fluoro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
N-(3-fluoro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
N-(3-fluoro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
1.56 microg/ml
additional information
N-(3-fluoro-4-pyrrolidin-1-ylphenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
N-(4-chlorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
0.195 microg/ml
additional information
N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
larger than 6.25 microg/ml
additional information
N-(4-fluorophenyl)-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
0.0000023
N-[(cyclohexyloxy)carbonyl]-1-[(2R)-3-cyclopentyl-2-[[formyl(hydroxy)amino]methyl]propanoyl]-L-prolinamide
Haemophilus influenzae
-
in 50 mM potassium phosphate (pH 7.6), at 25C
-
additional information
N-[3-chloro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
3.13 microg/ml
additional information
N-[3-chloro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
N-[3-chloro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis, Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
N-[3-chloro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.39 microg/ml
additional information
N-[3-fluoro-4-(1-oxidopiperidin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
3.13 microg/ml
additional information
N-[3-fluoro-4-(1-oxidopiperidin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis, Staphylococcus epidermidis
-
1.56 microg/ml
additional information
N-[3-fluoro-4-(1-oxidopiperidin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
N-[3-fluoro-4-(1-oxidopiperidin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.78 microg/ml
additional information
N-[3-fluoro-4-(1H-pyrrol-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.39 microg/ml
additional information
N-[3-fluoro-4-(1H-pyrrol-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
0.049 microg/ml
additional information
N-[3-fluoro-4-(1H-pyrrol-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.195 microg/ml
additional information
N-[3-fluoro-4-(1H-pyrrol-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
0.39 microg/ml
additional information
N-[3-fluoro-4-(1H-pyrrol-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.049 microg/ml
additional information
N-[3-fluoro-4-(4-methyl-1,4-diazepan-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
0.78 microg/ml
additional information
N-[3-fluoro-4-(4-methyl-1,4-diazepan-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis
-
1.56 microg/ml
additional information
N-[3-fluoro-4-(4-methyl-1,4-diazepan-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.78 microg/ml
additional information
N-[3-fluoro-4-(4-methyl-1,4-diazepan-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
1.56 microg/ml
additional information
N-[3-fluoro-4-(4-methyl-1,4-diazepan-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.39 microg/ml
additional information
N-[3-fluoro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus
-
3.13 microg/ml
additional information
N-[3-fluoro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus enteridis, Staphylococcus epidermidis
-
1.56 microg/ml
additional information
N-[3-fluoro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
larger than 6.25 microg/ml
additional information
N-[3-fluoro-4-(4-oxidomorpholin-4-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.39 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis
-
1.56 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.39 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
3.13 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.098 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus aureus, Staphylococcus enteridis
-
3.13 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus epidermidis
-
0.78 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Staphylococcus non-hemolyticus
-
6.25 microg/ml
additional information
N-[4-(4-ethylpiperazin-1-yl)phenyl]-1-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-L-prolinamide
Streptococcus pneumoniae
-
0.195 microg/ml
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
97.2
-
Ni2+-bound enzyme
1200
-
Fe2+- and Ni2+-bound enzyme
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6
-
for purified and modified PfPDF
6 - 7
-
formylation
6 - 7.2
-
-
7
-
AAP PDF inhibition assay; DPPI PDF inhibition assay
7.2
-
deformylation
7.4
-
activity assay
7.5
activity assay
7.5
-
activity assay
8.5
-
mutant E133D Co2+-bound enzyme
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.1 - 11.2
-
deformylation, nearly constant activity in this range
6.5 - 11
pH 6.5: about 55% of maximal activity, pH 11.0: about 90% of maximal activity
6.5 - 11.2
-
constant activity within
6.5 - 11.6
-
optimal activity within, Fe2+- and Co2+-bound enzyme
7 - 11
-
pH 7.0: about 70% of maximal activity, pH 11.0: about 65% of maximal activity
7.5 - 9.5
-
mutant E133D Co2+-bound enzyme
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
25
-
activity assay
25
-
room temperature, AAP PDF inhibition assay; room temperature, DPPI PDF inhibition assay
25 - 50
-
-
30
-
mPDF, activity assay
30
-
activity assay
37
activity assay
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40 - 60
40C: about 50% of maximal activity, 60C, about 70% of maximal activity
50 - 80
-
50C: about 75% of maximal activity, 80C: about 70% of maximal activity