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Literature summary for 3.5.1.109 extracted from

  • Imokawa, G.
    A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide (2009), J. Dermatol. Sci., 55, 1-9.
    View publication on PubMed
Search for more literature for 3.5.1.109

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 1 * 40000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-palmitoyl-D-glucosylsphingosine + H2O Homo sapiens
-
 palmitic acid + D-glucosylsphingosine
-
 ?
N-palmitoyl-sphingosylphosphorylcholine + H2O Homo sapiens
-
 palmitic acid + sphingosylphosphorylcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
stratum corneum activity is enhanced more than 5fold in involved stratum corneum, more than 3fold in uninvolved stratum corneum, and approximately 3fold in the involved epidermis from patients with atopic dermatitis compared with healthy controls Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-palmitoyl-D-glucosylsphingosine + H2O
-
 Homo sapiens palmitic acid + D-glucosylsphingosine
-
 ?
N-palmitoyl-sphingosylphosphorylcholine + H2O
-
 Homo sapiens palmitic acid + sphingosylphosphorylcholine
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 40000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
SM glucosylceramide GCer deacylase
-
 Homo sapiens
SM-GCer deacylase
-
 Homo sapiens
SMGCer deacylase
-
 Homo sapiens
sphingomyelin glucosylceramide deacylase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens sphingomyelin deacylase activity, isoelectric focusing
-
 4.2

General Information

General Information Comment Organism
physiological function the abnormal expression of sphingomyelin deacylase, which acts as a by-pass enzyme and competes with EC 3.1.4.12 (sphingomyelin phosphodiesterase) as well as EC 3.2.1.45 (glucosylceramidase) for N-acyl-sphingosylphosphorylcholine and D-glucosyl-N-acylsphingosine, respectively, is mainly responsible for the ceramide deficiency in patients with atopic dermatitis. The biogenesis of EC 3.1.4.12 (sphingomyelin phosphodiesterase) as well as EC 3.2.1.45 (glucosylceramidase) may be critical to the pathogenesis of atopic dermatitis Homo sapiens